Investigating the Efficacy of L-Arginine and Aged Garlic Extract in a Randomised Place-Controlled Clinical Trial: A Vasodilatory Nutraceutical Strategy for Migraine Prevention
While studies imply it is cerebral vasodilation that triggers migraine pain onset, we suggest the carbon-dioxide-inducing vasodilation rescues migraine phenotype by restoring central capillary perfusion instead. We conducted a 12-week, phase-II, single-site, randomised, double-blind, parallel-group,...
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| Format: | Thesis |
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Curtin University
2024
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| Online Access: | http://hdl.handle.net/20.500.11937/97135 |
| _version_ | 1848766226725076992 |
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| author | Chaliha, Devahuti Rai |
| author_facet | Chaliha, Devahuti Rai |
| author_sort | Chaliha, Devahuti Rai |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | While studies imply it is cerebral vasodilation that triggers migraine pain onset, we suggest the carbon-dioxide-inducing vasodilation rescues migraine phenotype by restoring central capillary perfusion instead. We conducted a 12-week, phase-II, single-site, randomised, double-blind, parallel-group, placebo-controlled trial in male and female adults with chronic frequent episodic migraines (4 treatment arms: placebo, L-arginine, aged garlic extract (AGE), and L-arginine + 1 g AGE). The descending order of efficacy was as follows: L-arginine, then AGE, then combination. |
| first_indexed | 2025-11-14T11:47:47Z |
| format | Thesis |
| id | curtin-20.500.11937-97135 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:47:47Z |
| publishDate | 2024 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-971352025-02-14T06:30:34Z Investigating the Efficacy of L-Arginine and Aged Garlic Extract in a Randomised Place-Controlled Clinical Trial: A Vasodilatory Nutraceutical Strategy for Migraine Prevention Chaliha, Devahuti Rai While studies imply it is cerebral vasodilation that triggers migraine pain onset, we suggest the carbon-dioxide-inducing vasodilation rescues migraine phenotype by restoring central capillary perfusion instead. We conducted a 12-week, phase-II, single-site, randomised, double-blind, parallel-group, placebo-controlled trial in male and female adults with chronic frequent episodic migraines (4 treatment arms: placebo, L-arginine, aged garlic extract (AGE), and L-arginine + 1 g AGE). The descending order of efficacy was as follows: L-arginine, then AGE, then combination. 2024 Thesis http://hdl.handle.net/20.500.11937/97135 Curtin University fulltext |
| spellingShingle | Chaliha, Devahuti Rai Investigating the Efficacy of L-Arginine and Aged Garlic Extract in a Randomised Place-Controlled Clinical Trial: A Vasodilatory Nutraceutical Strategy for Migraine Prevention |
| title | Investigating the Efficacy of L-Arginine and Aged Garlic Extract in a Randomised Place-Controlled Clinical Trial: A Vasodilatory Nutraceutical Strategy for Migraine Prevention |
| title_full | Investigating the Efficacy of L-Arginine and Aged Garlic Extract in a Randomised Place-Controlled Clinical Trial: A Vasodilatory Nutraceutical Strategy for Migraine Prevention |
| title_fullStr | Investigating the Efficacy of L-Arginine and Aged Garlic Extract in a Randomised Place-Controlled Clinical Trial: A Vasodilatory Nutraceutical Strategy for Migraine Prevention |
| title_full_unstemmed | Investigating the Efficacy of L-Arginine and Aged Garlic Extract in a Randomised Place-Controlled Clinical Trial: A Vasodilatory Nutraceutical Strategy for Migraine Prevention |
| title_short | Investigating the Efficacy of L-Arginine and Aged Garlic Extract in a Randomised Place-Controlled Clinical Trial: A Vasodilatory Nutraceutical Strategy for Migraine Prevention |
| title_sort | investigating the efficacy of l-arginine and aged garlic extract in a randomised place-controlled clinical trial: a vasodilatory nutraceutical strategy for migraine prevention |
| url | http://hdl.handle.net/20.500.11937/97135 |