Induction of interferon-stimulated genes and cellular stress pathways by morpholinos in zebrafish

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Induction of interferon-stimulated genes and cellular stress pathways by morpholinos in zebrafish

The phenotypes caused by morpholino-mediated interference of gene function in zebrafish are often not observed in the corresponding mutant(s). We took advantage of the availability of a relatively large collection of transcriptomic datasets to identify common signatures that characterize morpholino-...

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Bibliographic Details
Main Authors:	Lai, J.K.H., Gagalova, Kristina, Kuenne, C., El-Brolosy, M.A., Stainier, D.Y.R.
Format:	Journal Article
Language:	English
Published:	2019
Subjects:	ISG Knockdown Morpholino Mutant Zebrafish p53 Animals Down-Regulation Embryo, Nonmammalian Gene Expression Profiling Gene Expression Regulation, Developmental Gene Knockdown Techniques Interferons Morpholinos Mutation Phenotype Stress, Physiological Tumor Suppressor Protein p53 Up-Regulation Zebrafish Proteins
Online Access:	http://hdl.handle.net/20.500.11937/96872

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