| Summary: | The present article reviews the major historical plague epidemics that characterised human history by combining data derived from historical sources and biomedical evidence emerged in recent years thanks to advancements of palaeogenetics and pal-aeopathology. Notes are offered on the Plague of Athens, the Antonine Plague, the Plague of Cyprian, the Justinian Plague, the Black Death down to more recent centuries and presenting key aspects that continued to be preserved over time and would also partly char-acterise the recent COVID-19 pandemic.
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