Emerging Mechanisms of Physical Exercise Benefits in Adjuvant and Neoadjuvant Cancer Immunotherapy.
The primary factors that can be modified in one's lifestyle are the most influential determinants and significant preventable causes of various types of cancer. Exercise has demonstrated numerous advantages in preventing cancer and aiding in its treatment. However, the precise mechanisms behind...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/96559 |
| _version_ | 1848766172039741440 |
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| author | Casciano, Fabio Caruso, Lorenzo Zauli, Enrico Gonelli, Arianna Zauli, Giorgio Vaccarezza, Mauro |
| author_facet | Casciano, Fabio Caruso, Lorenzo Zauli, Enrico Gonelli, Arianna Zauli, Giorgio Vaccarezza, Mauro |
| author_sort | Casciano, Fabio |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The primary factors that can be modified in one's lifestyle are the most influential determinants and significant preventable causes of various types of cancer. Exercise has demonstrated numerous advantages in preventing cancer and aiding in its treatment. However, the precise mechanisms behind these effects are still not fully understood. To contribute to our comprehension of exercise's impact on cancer immunotherapy and provide recommendations for future research in exercise oncology, we will examine the roles and underlying mechanisms of exercise on immune cells. In addition to reducing the likelihood of developing cancer, exercise can also improve the effectiveness of certain approved anticancer treatments, such as targeted therapy, immunotherapy, and radiotherapy. Exercise is a pivotal modulator of the immune response, and thus, it can play an emerging important role in new immunotherapies. The mechanisms responsible for these effects involve the regulation of intra-tumoral angiogenesis, myokines, adipokines, their associated pathways, cancer metabolism, and anticancer immunity. Our review assesses the potential of physical exercise as an adjuvant/neoadjuvant tool, reducing the burden of cancer relapse, and analyzes emerging molecular mechanisms predicting favorable adjuvanticity effects. |
| first_indexed | 2025-11-14T11:46:55Z |
| format | Journal Article |
| id | curtin-20.500.11937-96559 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:46:55Z |
| publishDate | 2024 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-965592025-01-17T05:41:56Z Emerging Mechanisms of Physical Exercise Benefits in Adjuvant and Neoadjuvant Cancer Immunotherapy. Casciano, Fabio Caruso, Lorenzo Zauli, Enrico Gonelli, Arianna Zauli, Giorgio Vaccarezza, Mauro immune response immunotherapy lifestyle oncology physical exercise tumor microenvironment The primary factors that can be modified in one's lifestyle are the most influential determinants and significant preventable causes of various types of cancer. Exercise has demonstrated numerous advantages in preventing cancer and aiding in its treatment. However, the precise mechanisms behind these effects are still not fully understood. To contribute to our comprehension of exercise's impact on cancer immunotherapy and provide recommendations for future research in exercise oncology, we will examine the roles and underlying mechanisms of exercise on immune cells. In addition to reducing the likelihood of developing cancer, exercise can also improve the effectiveness of certain approved anticancer treatments, such as targeted therapy, immunotherapy, and radiotherapy. Exercise is a pivotal modulator of the immune response, and thus, it can play an emerging important role in new immunotherapies. The mechanisms responsible for these effects involve the regulation of intra-tumoral angiogenesis, myokines, adipokines, their associated pathways, cancer metabolism, and anticancer immunity. Our review assesses the potential of physical exercise as an adjuvant/neoadjuvant tool, reducing the burden of cancer relapse, and analyzes emerging molecular mechanisms predicting favorable adjuvanticity effects. 2024 Journal Article http://hdl.handle.net/20.500.11937/96559 10.3390/biomedicines12112528 eng http://creativecommons.org/licenses/by/4.0/ fulltext |
| spellingShingle | immune response immunotherapy lifestyle oncology physical exercise tumor microenvironment Casciano, Fabio Caruso, Lorenzo Zauli, Enrico Gonelli, Arianna Zauli, Giorgio Vaccarezza, Mauro Emerging Mechanisms of Physical Exercise Benefits in Adjuvant and Neoadjuvant Cancer Immunotherapy. |
| title | Emerging Mechanisms of Physical Exercise Benefits in Adjuvant and Neoadjuvant Cancer Immunotherapy. |
| title_full | Emerging Mechanisms of Physical Exercise Benefits in Adjuvant and Neoadjuvant Cancer Immunotherapy. |
| title_fullStr | Emerging Mechanisms of Physical Exercise Benefits in Adjuvant and Neoadjuvant Cancer Immunotherapy. |
| title_full_unstemmed | Emerging Mechanisms of Physical Exercise Benefits in Adjuvant and Neoadjuvant Cancer Immunotherapy. |
| title_short | Emerging Mechanisms of Physical Exercise Benefits in Adjuvant and Neoadjuvant Cancer Immunotherapy. |
| title_sort | emerging mechanisms of physical exercise benefits in adjuvant and neoadjuvant cancer immunotherapy. |
| topic | immune response immunotherapy lifestyle oncology physical exercise tumor microenvironment |
| url | http://hdl.handle.net/20.500.11937/96559 |