An attractive family of cyclometalated Ir(III) dyes functionalized with tryptophan for potential neuroimaging applications
Three novel luminescent iridium(III) dyes functionalized with a tryptophan amino acid and bearing two cyclometalated 2-phenylpyridines, 2-(2,4-difluorophenyl)pyridines or 2-phenylquinolines have been prepared and well characterized. They emit at 522–561 nm with a luminescence quantum yield in the ra...
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| Format: | Journal Article |
| Language: | English |
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ELSEVIER SCI LTD
2023
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| Online Access: | http://purl.org/au-research/grants/arc/DP220103091 http://hdl.handle.net/20.500.11937/96433 |
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| author | De Soricellis, G. Fagnani, F. Colombo, A. Dragonetti, C. Roberto, D. Marinotto, D. Hartnell, D.H. Hackett, Mark Massi, Max Carboni, B. Guerchais, V. |
| author_facet | De Soricellis, G. Fagnani, F. Colombo, A. Dragonetti, C. Roberto, D. Marinotto, D. Hartnell, D.H. Hackett, Mark Massi, Max Carboni, B. Guerchais, V. |
| author_sort | De Soricellis, G. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Three novel luminescent iridium(III) dyes functionalized with a tryptophan amino acid and bearing two cyclometalated 2-phenylpyridines, 2-(2,4-difluorophenyl)pyridines or 2-phenylquinolines have been prepared and well characterized. They emit at 522–561 nm with a luminescence quantum yield in the range 0.33–0.98. All the dyes are able to stain neuronal cells in rat cerebellum tissue, as evidenced by fluorescence microscopy, showing affinity for granule neurons. The complexes bearing cyclometalated 2-(2,4-difluorophenyl)pyridines or 2-phenylquinolines also have a good affinity for brain white matter. The dye with two cyclometalated 2-phenylquinolines is characterized by the best luminescence quantum yield (0.98). Besides, giving the greatest image contrast, the dye with two cyclometalated 2-phenylquinolines shows the strongest affinity for a distinct subtype of neurons found in cerebellum tissue, the purkinje neurons (as evidenced with fluorescence microscopy). |
| first_indexed | 2025-11-14T11:46:34Z |
| format | Journal Article |
| id | curtin-20.500.11937-96433 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:46:34Z |
| publishDate | 2023 |
| publisher | ELSEVIER SCI LTD |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-964332024-12-18T01:31:03Z An attractive family of cyclometalated Ir(III) dyes functionalized with tryptophan for potential neuroimaging applications De Soricellis, G. Fagnani, F. Colombo, A. Dragonetti, C. Roberto, D. Marinotto, D. Hartnell, D.H. Hackett, Mark Massi, Max Carboni, B. Guerchais, V. Science & Technology Physical Sciences Technology Chemistry, Applied Engineering, Chemical Materials Science, Textiles Chemistry Engineering Materials Science Iridium dyes Cyclometalated iridium(III) phenanthroline complexes Phosphorescence Bio-imaging Optical markers Brain tissue staining NONLINEAR-OPTICAL PROPERTIES EXCITED-STATE PROPERTIES IRIDIUM(III) COMPLEXES 2-PHOTON ABSORPTION SUBSTITUTED 1,10-PHENANTHROLINES ELECTROLUMINESCENT DEVICES ENDOPLASMIC-RETICULUM PHOTOREDOX CATALYSIS III COMPLEXES LIGHT Three novel luminescent iridium(III) dyes functionalized with a tryptophan amino acid and bearing two cyclometalated 2-phenylpyridines, 2-(2,4-difluorophenyl)pyridines or 2-phenylquinolines have been prepared and well characterized. They emit at 522–561 nm with a luminescence quantum yield in the range 0.33–0.98. All the dyes are able to stain neuronal cells in rat cerebellum tissue, as evidenced by fluorescence microscopy, showing affinity for granule neurons. The complexes bearing cyclometalated 2-(2,4-difluorophenyl)pyridines or 2-phenylquinolines also have a good affinity for brain white matter. The dye with two cyclometalated 2-phenylquinolines is characterized by the best luminescence quantum yield (0.98). Besides, giving the greatest image contrast, the dye with two cyclometalated 2-phenylquinolines shows the strongest affinity for a distinct subtype of neurons found in cerebellum tissue, the purkinje neurons (as evidenced with fluorescence microscopy). 2023 Journal Article http://hdl.handle.net/20.500.11937/96433 10.1016/j.dyepig.2022.111012 English http://purl.org/au-research/grants/arc/DP220103091 http://creativecommons.org/licenses/by-nc-nd/4.0/ ELSEVIER SCI LTD fulltext |
| spellingShingle | Science & Technology Physical Sciences Technology Chemistry, Applied Engineering, Chemical Materials Science, Textiles Chemistry Engineering Materials Science Iridium dyes Cyclometalated iridium(III) phenanthroline complexes Phosphorescence Bio-imaging Optical markers Brain tissue staining NONLINEAR-OPTICAL PROPERTIES EXCITED-STATE PROPERTIES IRIDIUM(III) COMPLEXES 2-PHOTON ABSORPTION SUBSTITUTED 1,10-PHENANTHROLINES ELECTROLUMINESCENT DEVICES ENDOPLASMIC-RETICULUM PHOTOREDOX CATALYSIS III COMPLEXES LIGHT De Soricellis, G. Fagnani, F. Colombo, A. Dragonetti, C. Roberto, D. Marinotto, D. Hartnell, D.H. Hackett, Mark Massi, Max Carboni, B. Guerchais, V. An attractive family of cyclometalated Ir(III) dyes functionalized with tryptophan for potential neuroimaging applications |
| title | An attractive family of cyclometalated Ir(III) dyes functionalized with tryptophan for potential neuroimaging applications |
| title_full | An attractive family of cyclometalated Ir(III) dyes functionalized with tryptophan for potential neuroimaging applications |
| title_fullStr | An attractive family of cyclometalated Ir(III) dyes functionalized with tryptophan for potential neuroimaging applications |
| title_full_unstemmed | An attractive family of cyclometalated Ir(III) dyes functionalized with tryptophan for potential neuroimaging applications |
| title_short | An attractive family of cyclometalated Ir(III) dyes functionalized with tryptophan for potential neuroimaging applications |
| title_sort | attractive family of cyclometalated ir(iii) dyes functionalized with tryptophan for potential neuroimaging applications |
| topic | Science & Technology Physical Sciences Technology Chemistry, Applied Engineering, Chemical Materials Science, Textiles Chemistry Engineering Materials Science Iridium dyes Cyclometalated iridium(III) phenanthroline complexes Phosphorescence Bio-imaging Optical markers Brain tissue staining NONLINEAR-OPTICAL PROPERTIES EXCITED-STATE PROPERTIES IRIDIUM(III) COMPLEXES 2-PHOTON ABSORPTION SUBSTITUTED 1,10-PHENANTHROLINES ELECTROLUMINESCENT DEVICES ENDOPLASMIC-RETICULUM PHOTOREDOX CATALYSIS III COMPLEXES LIGHT |
| url | http://purl.org/au-research/grants/arc/DP220103091 http://hdl.handle.net/20.500.11937/96433 |