Characterization of Phosphorylated Targets in Ovarian Cancer
Unspecific symptoms lead to diagnosis of ovarian cancer (OC) at an advanced stage. We believe that the treatment with chemotherapy cycles induces resistance in patients through rewiring of the kinome pathways. In this study, we have generated combinational chemo-resistant OC cell lines to identify k...
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| Format: | Thesis |
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Curtin University
2024
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| Online Access: | http://hdl.handle.net/20.500.11937/96237 |
| _version_ | 1848766119103430656 |
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| author | Binju, Mudra |
| author_facet | Binju, Mudra |
| author_sort | Binju, Mudra |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Unspecific symptoms lead to diagnosis of ovarian cancer (OC) at an advanced stage. We believe that the treatment with chemotherapy cycles induces resistance in patients through rewiring of the kinome pathways. In this study, we have generated combinational chemo-resistant OC cell lines to identify kinases as potential drug targets in resistant subtypes. These findings were also validated in HGSOC patients’ samples. We aim to improve drug sensitivity and treatment for patients with acquired chemoresistance. |
| first_indexed | 2025-11-14T11:46:04Z |
| format | Thesis |
| id | curtin-20.500.11937-96237 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:46:04Z |
| publishDate | 2024 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-962372024-10-30T07:26:07Z Characterization of Phosphorylated Targets in Ovarian Cancer Binju, Mudra Unspecific symptoms lead to diagnosis of ovarian cancer (OC) at an advanced stage. We believe that the treatment with chemotherapy cycles induces resistance in patients through rewiring of the kinome pathways. In this study, we have generated combinational chemo-resistant OC cell lines to identify kinases as potential drug targets in resistant subtypes. These findings were also validated in HGSOC patients’ samples. We aim to improve drug sensitivity and treatment for patients with acquired chemoresistance. 2024 Thesis http://hdl.handle.net/20.500.11937/96237 Curtin University restricted |
| spellingShingle | Binju, Mudra Characterization of Phosphorylated Targets in Ovarian Cancer |
| title | Characterization of Phosphorylated Targets in Ovarian Cancer |
| title_full | Characterization of Phosphorylated Targets in Ovarian Cancer |
| title_fullStr | Characterization of Phosphorylated Targets in Ovarian Cancer |
| title_full_unstemmed | Characterization of Phosphorylated Targets in Ovarian Cancer |
| title_short | Characterization of Phosphorylated Targets in Ovarian Cancer |
| title_sort | characterization of phosphorylated targets in ovarian cancer |
| url | http://hdl.handle.net/20.500.11937/96237 |