Novel mechanisms of Fn14 signalling and its regulation
This study investigated the molecular mechanisms regulating TWEAKindependent Fn14 signalling to identify barriers preventing successful targeting of the TWEAK/Fn14 signalling pathway. The principal discovery was that alternative splicing produces a novel Fn14 Isoform, called Fn14 Isoform 2, which ha...
| Main Author: | |
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| Format: | Thesis |
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Curtin University
2024
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| Online Access: | http://hdl.handle.net/20.500.11937/96122 |
| _version_ | 1848766094734524416 |
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| author | Main, Nathan Michael |
| author_facet | Main, Nathan Michael |
| author_sort | Main, Nathan Michael |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This study investigated the molecular mechanisms regulating TWEAKindependent Fn14 signalling to identify barriers preventing successful targeting of the TWEAK/Fn14 signalling pathway. The principal discovery was that alternative splicing produces a novel Fn14 Isoform, called Fn14 Isoform 2, which has the capacity to activate in the absence of TWEAK. |
| first_indexed | 2025-11-14T11:45:41Z |
| format | Thesis |
| id | curtin-20.500.11937-96122 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:45:41Z |
| publishDate | 2024 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-961222024-10-15T05:30:49Z Novel mechanisms of Fn14 signalling and its regulation Main, Nathan Michael This study investigated the molecular mechanisms regulating TWEAKindependent Fn14 signalling to identify barriers preventing successful targeting of the TWEAK/Fn14 signalling pathway. The principal discovery was that alternative splicing produces a novel Fn14 Isoform, called Fn14 Isoform 2, which has the capacity to activate in the absence of TWEAK. 2024 Thesis http://hdl.handle.net/20.500.11937/96122 Curtin University restricted |
| spellingShingle | Main, Nathan Michael Novel mechanisms of Fn14 signalling and its regulation |
| title | Novel mechanisms of Fn14 signalling and its regulation |
| title_full | Novel mechanisms of Fn14 signalling and its regulation |
| title_fullStr | Novel mechanisms of Fn14 signalling and its regulation |
| title_full_unstemmed | Novel mechanisms of Fn14 signalling and its regulation |
| title_short | Novel mechanisms of Fn14 signalling and its regulation |
| title_sort | novel mechanisms of fn14 signalling and its regulation |
| url | http://hdl.handle.net/20.500.11937/96122 |