Cancer associated mutations in Sec61γ alter the permeability of the ER translocase

Cancer associated mutations in Sec61γ alter the permeability of the ER translocase

Translocation of secretory and integral membrane proteins across or into the ER membrane occurs via the Sec61 complex, a heterotrimeric protein complex possessing two essential sub-units, Sec61p/Sec61a and Sss1p/Sec61γ and the non-essential Sbh1p/Sec61β subunit. In addition to forming a protein cond...

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Bibliographic Details
Main Authors: Witham, Christopher M., Paxman, Aleshanee L., Baklous, Lamprini, Steuart, Robert F.L., Schulz, B.L., Mousley, Carl J.
Format: Journal Article
Language:English
Published: PUBLIC LIBRARY SCIENCE 2021
Subjects:
Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
SIGNAL RECOGNITION PROTEIN
ENDOPLASMIC-RETICULUM
MEMBRANE-PROTEIN
BOUND RIBOSOMES
CROSS-LINKING
CA2+
YEAST
PEPTIDE
CHANNEL
SSS1P
Amino Acid Sequence
Biological Transport
Cell Membrane Permeability
Endoplasmic Reticulum
Membrane Proteins
Membrane Transport Proteins
Mutation
Neoplasms
Protein Transport
SEC Translocation Channels
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Online Access:http://hdl.handle.net/20.500.11937/96048

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