Bile acids for probucol formulations applications in drug induced ototoxicity
Within this thesis, probucol’s otoprotective application is assessed in vitro on House Ear Institute-Organ of Corti 1 (HEI-OC1) using three different formulation methods; 1) spray dried, 2) chitosan films or 3) supramolecular aggregates. To improve pre-formulation stability and drug loading, probuco...
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| Format: | Thesis |
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Curtin University
2024
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| Online Access: | http://hdl.handle.net/20.500.11937/96021 |
| _version_ | 1848766074649051136 |
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| author | Ionescu, Corina Mihaela |
| author_facet | Ionescu, Corina Mihaela |
| author_sort | Ionescu, Corina Mihaela |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Within this thesis, probucol’s otoprotective application is assessed in vitro on House Ear Institute-Organ of Corti 1 (HEI-OC1) using three different formulation methods; 1) spray dried, 2) chitosan films or 3) supramolecular aggregates. To improve pre-formulation stability and drug loading, probucol is tested in combination with unconjugated and conjugated bile acids (cholic acid, deoxycholic acid, chenodeoxycholic acid, ursodeoxycholic acid, taurocholic acid, lithocholic acid). |
| first_indexed | 2025-11-14T11:45:22Z |
| format | Thesis |
| id | curtin-20.500.11937-96021 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:45:22Z |
| publishDate | 2024 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-960212024-10-07T02:36:05Z Bile acids for probucol formulations applications in drug induced ototoxicity Ionescu, Corina Mihaela Within this thesis, probucol’s otoprotective application is assessed in vitro on House Ear Institute-Organ of Corti 1 (HEI-OC1) using three different formulation methods; 1) spray dried, 2) chitosan films or 3) supramolecular aggregates. To improve pre-formulation stability and drug loading, probucol is tested in combination with unconjugated and conjugated bile acids (cholic acid, deoxycholic acid, chenodeoxycholic acid, ursodeoxycholic acid, taurocholic acid, lithocholic acid). 2024 Thesis http://hdl.handle.net/20.500.11937/96021 Curtin University fulltext |
| spellingShingle | Ionescu, Corina Mihaela Bile acids for probucol formulations applications in drug induced ototoxicity |
| title | Bile acids for probucol formulations applications in drug induced
ototoxicity |
| title_full | Bile acids for probucol formulations applications in drug induced
ototoxicity |
| title_fullStr | Bile acids for probucol formulations applications in drug induced
ototoxicity |
| title_full_unstemmed | Bile acids for probucol formulations applications in drug induced
ototoxicity |
| title_short | Bile acids for probucol formulations applications in drug induced
ototoxicity |
| title_sort | bile acids for probucol formulations applications in drug induced
ototoxicity |
| url | http://hdl.handle.net/20.500.11937/96021 |