A commentary on studies of brain iron accumulation during ageing
Brain iron content is widely reported to increase during “ageing”, across multiple species from nematodes, rodents (mice and rats) and humans. Given the redox-active properties of iron, there has been a large research focus on iron-mediated oxidative stress as a contributor to tissue damage during n...
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| Format: | Journal Article |
| Language: | English |
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2024
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| Online Access: | http://purl.org/au-research/grants/arc/FT190100017 http://hdl.handle.net/20.500.11937/96001 |
| _version_ | 1848766069914730496 |
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| author | Hackett, Mark |
| author_facet | Hackett, Mark |
| author_sort | Hackett, Mark |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Brain iron content is widely reported to increase during “ageing”, across multiple species from nematodes, rodents (mice and rats) and humans. Given the redox-active properties of iron, there has been a large research focus on iron-mediated oxidative stress as a contributor to tissue damage during natural ageing, and also as a risk factor for neurodegenerative disease. Surprisingly, however, the majority of published studies have not investigated brain iron homeostasis during the biological time period of senescence, and thus knowledge of how brain homeostasis changes during this critical stage of life largely remains unknown. This commentary examines the literature published on the topic of brain iron homeostasis during ageing, providing a critique on limitations of currently used experimental designs. The commentary also aims to highlight that although much research attention has been given to iron accumulation or iron overload as a pathological feature of ageing, there is evidence to support functional iron deficiency may exist, and this should not be overlooked in studies of ageing or neurodegenerative disease. Graphical abstract: (Figure presented.). |
| first_indexed | 2025-11-14T11:45:17Z |
| format | Journal Article |
| id | curtin-20.500.11937-96001 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:45:17Z |
| publishDate | 2024 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-960012024-10-10T05:37:53Z A commentary on studies of brain iron accumulation during ageing Hackett, Mark Brain rust Metallomics Senescence X-ray fluorescence XFM Aging Iron Humans Animals Brain Homeostasis Brain Animals Humans Iron Aging Homeostasis Brain iron content is widely reported to increase during “ageing”, across multiple species from nematodes, rodents (mice and rats) and humans. Given the redox-active properties of iron, there has been a large research focus on iron-mediated oxidative stress as a contributor to tissue damage during natural ageing, and also as a risk factor for neurodegenerative disease. Surprisingly, however, the majority of published studies have not investigated brain iron homeostasis during the biological time period of senescence, and thus knowledge of how brain homeostasis changes during this critical stage of life largely remains unknown. This commentary examines the literature published on the topic of brain iron homeostasis during ageing, providing a critique on limitations of currently used experimental designs. The commentary also aims to highlight that although much research attention has been given to iron accumulation or iron overload as a pathological feature of ageing, there is evidence to support functional iron deficiency may exist, and this should not be overlooked in studies of ageing or neurodegenerative disease. Graphical abstract: (Figure presented.). 2024 Journal Article http://hdl.handle.net/20.500.11937/96001 10.1007/s00775-024-02060-2 eng http://purl.org/au-research/grants/arc/FT190100017 http://creativecommons.org/licenses/by/4.0/ fulltext |
| spellingShingle | Brain rust Metallomics Senescence X-ray fluorescence XFM Aging Iron Humans Animals Brain Homeostasis Brain Animals Humans Iron Aging Homeostasis Hackett, Mark A commentary on studies of brain iron accumulation during ageing |
| title | A commentary on studies of brain iron accumulation during ageing |
| title_full | A commentary on studies of brain iron accumulation during ageing |
| title_fullStr | A commentary on studies of brain iron accumulation during ageing |
| title_full_unstemmed | A commentary on studies of brain iron accumulation during ageing |
| title_short | A commentary on studies of brain iron accumulation during ageing |
| title_sort | commentary on studies of brain iron accumulation during ageing |
| topic | Brain rust Metallomics Senescence X-ray fluorescence XFM Aging Iron Humans Animals Brain Homeostasis Brain Animals Humans Iron Aging Homeostasis |
| url | http://purl.org/au-research/grants/arc/FT190100017 http://hdl.handle.net/20.500.11937/96001 |