Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes
Introduction: Preeclampsia is a common and partially genetic pregnancy complication characterized by hypertension and proteinuria. Association with cardiovascular disease and type 2 diabetes has been reported in 9p21 by several genome-wide association studies. It has been hypothesized that cardiomet...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
2016
|
| Online Access: | http://hdl.handle.net/20.500.11937/9589 |
| _version_ | 1848745993219080192 |
|---|---|
| author | Kaartokallio, T. Lokki, A. Peterson, H. Kivinen, K. Hiltunen, L. Salmela, E. Lappalainen, T. Maanselkä, P. Heino, S. Knuutila, S. Sayed, A. Poston, L. Brennecke, S. Johnson, M. Morgan, L. Moses, Eric Kere, J. Laivuori, H. |
| author_facet | Kaartokallio, T. Lokki, A. Peterson, H. Kivinen, K. Hiltunen, L. Salmela, E. Lappalainen, T. Maanselkä, P. Heino, S. Knuutila, S. Sayed, A. Poston, L. Brennecke, S. Johnson, M. Morgan, L. Moses, Eric Kere, J. Laivuori, H. |
| author_sort | Kaartokallio, T. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Introduction: Preeclampsia is a common and partially genetic pregnancy complication characterized by hypertension and proteinuria. Association with cardiovascular disease and type 2 diabetes has been reported in 9p21 by several genome-wide association studies. It has been hypothesized that cardiometabolic diseases may share common etiology with preeclampsia. Materials and methods: We tested association with the 9p21 region to preeclampsia in the Finnish population by genotyping 23 tagging single nucleotide polymorphisms (SNPs) in 15 extended preeclampsia families and in a nationwide cohort consisting of 281 cases and 349 matched controls. Replication was conducted in additional datasets. Results: Four SNPs (rs7044859, rs496892, rs564398 and rs7865618) showed nominal association (p ≤ uncorrected) with preeclampsia in the case-control cohort. To increase power, we genotyped two SNPs in additional 388 cases and 341 controls from the Finnish Genetics of Preeclampsia Consortium (FINNPEC) cohort. Partial replication was also attempted in a UK cohort (237 cases and 199 controls) and in 74 preeclamptic families from Australia/New Zealand. We were unable to replicate the initial association in the extended Finnish dataset or in the two international cohorts. Conclusions: Our study did not find evidence for the involvement of the 9p21 region in the risk of preeclampsia. Key message: Chromosome 9p21 is not associated with preeclampsia. |
| first_indexed | 2025-11-14T06:26:11Z |
| format | Journal Article |
| id | curtin-20.500.11937-9589 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:26:11Z |
| publishDate | 2016 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-95892017-09-13T14:51:29Z Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes Kaartokallio, T. Lokki, A. Peterson, H. Kivinen, K. Hiltunen, L. Salmela, E. Lappalainen, T. Maanselkä, P. Heino, S. Knuutila, S. Sayed, A. Poston, L. Brennecke, S. Johnson, M. Morgan, L. Moses, Eric Kere, J. Laivuori, H. Introduction: Preeclampsia is a common and partially genetic pregnancy complication characterized by hypertension and proteinuria. Association with cardiovascular disease and type 2 diabetes has been reported in 9p21 by several genome-wide association studies. It has been hypothesized that cardiometabolic diseases may share common etiology with preeclampsia. Materials and methods: We tested association with the 9p21 region to preeclampsia in the Finnish population by genotyping 23 tagging single nucleotide polymorphisms (SNPs) in 15 extended preeclampsia families and in a nationwide cohort consisting of 281 cases and 349 matched controls. Replication was conducted in additional datasets. Results: Four SNPs (rs7044859, rs496892, rs564398 and rs7865618) showed nominal association (p ≤ uncorrected) with preeclampsia in the case-control cohort. To increase power, we genotyped two SNPs in additional 388 cases and 341 controls from the Finnish Genetics of Preeclampsia Consortium (FINNPEC) cohort. Partial replication was also attempted in a UK cohort (237 cases and 199 controls) and in 74 preeclamptic families from Australia/New Zealand. We were unable to replicate the initial association in the extended Finnish dataset or in the two international cohorts. Conclusions: Our study did not find evidence for the involvement of the 9p21 region in the risk of preeclampsia. Key message: Chromosome 9p21 is not associated with preeclampsia. 2016 Journal Article http://hdl.handle.net/20.500.11937/9589 10.1080/07853890.2016.1174877 restricted |
| spellingShingle | Kaartokallio, T. Lokki, A. Peterson, H. Kivinen, K. Hiltunen, L. Salmela, E. Lappalainen, T. Maanselkä, P. Heino, S. Knuutila, S. Sayed, A. Poston, L. Brennecke, S. Johnson, M. Morgan, L. Moses, Eric Kere, J. Laivuori, H. Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes |
| title | Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes |
| title_full | Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes |
| title_fullStr | Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes |
| title_full_unstemmed | Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes |
| title_short | Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes |
| title_sort | preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes |
| url | http://hdl.handle.net/20.500.11937/9589 |