Towards Understanding the Role of Trisomy 21 in Down Syndrome Leukaemia
Acute lymphoblastic leukaemia (ALL) is the most common paediatric cancer (25% of all cases). Children with Down syndrome (constitutive trisomy 21) are predisposed to ALL with inferior prognosis compared to other children. I established novel models of DS-ALL to dissect the role of trisomy 21 and ide...
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| Format: | Thesis |
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Curtin University
2024
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| Online Access: | http://hdl.handle.net/20.500.11937/95646 |
| _version_ | 1848766037391048704 |
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| author | Carey-Smith, Shannon Lee |
| author_facet | Carey-Smith, Shannon Lee |
| author_sort | Carey-Smith, Shannon Lee |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Acute lymphoblastic leukaemia (ALL) is the most common paediatric cancer (25% of all cases). Children with Down syndrome (constitutive trisomy 21) are predisposed to ALL with inferior prognosis compared to other children. I established novel models of DS-ALL to dissect the role of trisomy 21 and identify new potent inhibitors of the chromosome 21 kinase DYRK1A. Altogether, this project provides new preclinical tools to improve the outcomes of children with Down syndrome that develop leukaemia. |
| first_indexed | 2025-11-14T11:44:46Z |
| format | Thesis |
| id | curtin-20.500.11937-95646 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:44:46Z |
| publishDate | 2024 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-956462024-08-05T06:29:23Z Towards Understanding the Role of Trisomy 21 in Down Syndrome Leukaemia Carey-Smith, Shannon Lee Acute lymphoblastic leukaemia (ALL) is the most common paediatric cancer (25% of all cases). Children with Down syndrome (constitutive trisomy 21) are predisposed to ALL with inferior prognosis compared to other children. I established novel models of DS-ALL to dissect the role of trisomy 21 and identify new potent inhibitors of the chromosome 21 kinase DYRK1A. Altogether, this project provides new preclinical tools to improve the outcomes of children with Down syndrome that develop leukaemia. 2024 Thesis http://hdl.handle.net/20.500.11937/95646 Curtin University fulltext |
| spellingShingle | Carey-Smith, Shannon Lee Towards Understanding the Role of Trisomy 21 in Down Syndrome Leukaemia |
| title | Towards Understanding the Role of Trisomy 21 in Down Syndrome Leukaemia |
| title_full | Towards Understanding the Role of Trisomy 21 in Down Syndrome Leukaemia |
| title_fullStr | Towards Understanding the Role of Trisomy 21 in Down Syndrome Leukaemia |
| title_full_unstemmed | Towards Understanding the Role of Trisomy 21 in Down Syndrome Leukaemia |
| title_short | Towards Understanding the Role of Trisomy 21 in Down Syndrome Leukaemia |
| title_sort | towards understanding the role of trisomy 21 in down syndrome leukaemia |
| url | http://hdl.handle.net/20.500.11937/95646 |