Synthesis and Biological Evaluation of Anti-Parasitic Compounds
Currently, there is a vital need for new treatment options for the vector-borne, parasitic protozoan diseases, which cause significant morbidity and mortality. This research focused on the synthesis of novel tetrahydroisoquinoline derivatives in order to investigate their anti-parasitic properties....
| Main Author: | |
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| Format: | Thesis |
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Curtin University
2024
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| Online Access: | http://hdl.handle.net/20.500.11937/95484 |
| _version_ | 1848766016227639296 |
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| author | Gallagher, Ashlee |
| author_facet | Gallagher, Ashlee |
| author_sort | Gallagher, Ashlee |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Currently, there is a vital need for new treatment options for the vector-borne, parasitic protozoan diseases, which cause significant morbidity and mortality. This research focused on the synthesis of novel tetrahydroisoquinoline derivatives in order to investigate their anti-parasitic properties. 54 novel derivatives were evaluated, with 3 compounds identified as promising candidates for pre-clinical development for human African trypanosomiasis. The scaffold also showed promise for both Chagas disease and Leishmaniasis, warranting further investigation. |
| first_indexed | 2025-11-14T11:44:26Z |
| format | Thesis |
| id | curtin-20.500.11937-95484 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:44:26Z |
| publishDate | 2024 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-954842024-07-09T01:53:39Z Synthesis and Biological Evaluation of Anti-Parasitic Compounds Gallagher, Ashlee Currently, there is a vital need for new treatment options for the vector-borne, parasitic protozoan diseases, which cause significant morbidity and mortality. This research focused on the synthesis of novel tetrahydroisoquinoline derivatives in order to investigate their anti-parasitic properties. 54 novel derivatives were evaluated, with 3 compounds identified as promising candidates for pre-clinical development for human African trypanosomiasis. The scaffold also showed promise for both Chagas disease and Leishmaniasis, warranting further investigation. 2024 Thesis http://hdl.handle.net/20.500.11937/95484 Curtin University restricted |
| spellingShingle | Gallagher, Ashlee Synthesis and Biological Evaluation of Anti-Parasitic Compounds |
| title | Synthesis and Biological Evaluation of Anti-Parasitic Compounds |
| title_full | Synthesis and Biological Evaluation of Anti-Parasitic Compounds |
| title_fullStr | Synthesis and Biological Evaluation of Anti-Parasitic Compounds |
| title_full_unstemmed | Synthesis and Biological Evaluation of Anti-Parasitic Compounds |
| title_short | Synthesis and Biological Evaluation of Anti-Parasitic Compounds |
| title_sort | synthesis and biological evaluation of anti-parasitic compounds |
| url | http://hdl.handle.net/20.500.11937/95484 |