Synthesis and Biological Evaluation of Anti-Parasitic Compounds
Currently, there is a vital need for new treatment options for the vector-borne, parasitic protozoan diseases, which cause significant morbidity and mortality. This research focused on the synthesis of novel tetrahydroisoquinoline derivatives in order to investigate their anti-parasitic properties....
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| Format: | Thesis |
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Curtin University
2024
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| Online Access: | http://hdl.handle.net/20.500.11937/95484 |
| Summary: | Currently, there is a vital need for new treatment options for the vector-borne, parasitic protozoan diseases, which cause significant morbidity and mortality. This research focused on the synthesis of novel tetrahydroisoquinoline derivatives in order to investigate their anti-parasitic properties. 54 novel derivatives were evaluated, with 3 compounds identified as promising candidates for pre-clinical development for human African trypanosomiasis. The scaffold also showed promise for both Chagas disease and Leishmaniasis, warranting further investigation. |
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