Human cerebral blood supply via circulus arteriosus cerebri: A scoping review on its variations and clinical implications
Background Circulus arteriosus cerebri (CAC), responsible for supplying blood to the brain, presents anatomical variations that have been associated with both haemorrhagic and ischemic strokes. Therefore, it is crucial to conduct comprehensive investigations and comparisons of the diverse variant co...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier
2024
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/95413 |
| _version_ | 1848766008124243968 |
|---|---|
| author | Ahmad, Adilah F Galassi, Francesco M Burlakoti, Arjun Vaccarezza, Mauro Papa, Veronica |
| author_facet | Ahmad, Adilah F Galassi, Francesco M Burlakoti, Arjun Vaccarezza, Mauro Papa, Veronica |
| author_sort | Ahmad, Adilah F |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background
Circulus arteriosus cerebri (CAC), responsible for supplying blood to the brain, presents anatomical variations that have been associated with both haemorrhagic and ischemic strokes. Therefore, it is crucial to conduct comprehensive investigations and comparisons of the diverse variant components of the CAC, published in various journals, and analyze them to identify individuals at risk of cerebrovascular pathologies, thereby ensuring enhanced and timely treatment.
Methods
A scoping review according to the five-stage protocol by Arksey and O'Malley was performed between February and June 2023. Seven hundred and seventy-seven records were initially identified, and a total of 51 studies were finally included.
Results
This scoping review focuses on the anatomical variations of the CAC and their clinical implications on cerebrovascular disease and includes more original articles than review s. Consistent with previous findings, most of the records included small populations or samples, while only three records reported larger populations. Surprisingly, the populations enclosed in the included records consisted of autopsied cadaveric specimens more than living subjects. Finally, the qualitative analysis highlighted three main themes concerning the relationship between the normal CAC morphology and the cerebrovascular disease onset as well as the variant CAC morphology and its main features that might be also involved in these diseases. Finally, techniques that can be used to measure CAC have also been assessed.
Conclusion
Variations in the CAC, more common in the posterior part, with genetic and environmental factors influencing these variations impact cerebrovascular disorders. Understanding variants components of CAC can aid in improving brain surgeries and post-stroke care. |
| first_indexed | 2025-11-14T11:44:18Z |
| format | Journal Article |
| id | curtin-20.500.11937-95413 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:44:18Z |
| publishDate | 2024 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-954132024-08-23T03:39:54Z Human cerebral blood supply via circulus arteriosus cerebri: A scoping review on its variations and clinical implications Ahmad, Adilah F Galassi, Francesco M Burlakoti, Arjun Vaccarezza, Mauro Papa, Veronica Circle of Willis Cerebral artery Angiography Aneurysm Stroke Anatomical variation Background Circulus arteriosus cerebri (CAC), responsible for supplying blood to the brain, presents anatomical variations that have been associated with both haemorrhagic and ischemic strokes. Therefore, it is crucial to conduct comprehensive investigations and comparisons of the diverse variant components of the CAC, published in various journals, and analyze them to identify individuals at risk of cerebrovascular pathologies, thereby ensuring enhanced and timely treatment. Methods A scoping review according to the five-stage protocol by Arksey and O'Malley was performed between February and June 2023. Seven hundred and seventy-seven records were initially identified, and a total of 51 studies were finally included. Results This scoping review focuses on the anatomical variations of the CAC and their clinical implications on cerebrovascular disease and includes more original articles than review s. Consistent with previous findings, most of the records included small populations or samples, while only three records reported larger populations. Surprisingly, the populations enclosed in the included records consisted of autopsied cadaveric specimens more than living subjects. Finally, the qualitative analysis highlighted three main themes concerning the relationship between the normal CAC morphology and the cerebrovascular disease onset as well as the variant CAC morphology and its main features that might be also involved in these diseases. Finally, techniques that can be used to measure CAC have also been assessed. Conclusion Variations in the CAC, more common in the posterior part, with genetic and environmental factors influencing these variations impact cerebrovascular disorders. Understanding variants components of CAC can aid in improving brain surgeries and post-stroke care. 2024 Journal Article http://hdl.handle.net/20.500.11937/95413 10.1016/j.heliyon.2024.e32648 English http://creativecommons.org/licenses/by-nc/4.0/ Elsevier unknown |
| spellingShingle | Circle of Willis Cerebral artery Angiography Aneurysm Stroke Anatomical variation Ahmad, Adilah F Galassi, Francesco M Burlakoti, Arjun Vaccarezza, Mauro Papa, Veronica Human cerebral blood supply via circulus arteriosus cerebri: A scoping review on its variations and clinical implications |
| title | Human cerebral blood supply via circulus arteriosus cerebri: A scoping review on its variations and clinical implications |
| title_full | Human cerebral blood supply via circulus arteriosus cerebri: A scoping review on its variations and clinical implications |
| title_fullStr | Human cerebral blood supply via circulus arteriosus cerebri: A scoping review on its variations and clinical implications |
| title_full_unstemmed | Human cerebral blood supply via circulus arteriosus cerebri: A scoping review on its variations and clinical implications |
| title_short | Human cerebral blood supply via circulus arteriosus cerebri: A scoping review on its variations and clinical implications |
| title_sort | human cerebral blood supply via circulus arteriosus cerebri: a scoping review on its variations and clinical implications |
| topic | Circle of Willis Cerebral artery Angiography Aneurysm Stroke Anatomical variation |
| url | http://hdl.handle.net/20.500.11937/95413 |