Establishing a Bioluminescent Screening Platform to Identify Stromal-Mediated Chemoresistance in Leukaemia
The tumour microenvironment has been shown to support cancer progression and regulate responsiveness to drug treatment. In leukaemia, chemoresistance is often facilitated by stromal cells of the bone marrow microenvironment. In this project, we established a co-culture drug screening pipeline and di...
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| Format: | Thesis |
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Curtin University
2024
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| Online Access: | http://hdl.handle.net/20.500.11937/95307 |
| _version_ | 1848765997387874304 |
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| author | Panting, Rhiannon |
| author_facet | Panting, Rhiannon |
| author_sort | Panting, Rhiannon |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The tumour microenvironment has been shown to support cancer progression and regulate responsiveness to drug treatment. In leukaemia, chemoresistance is often facilitated by stromal cells of the bone marrow microenvironment. In this project, we established a co-culture drug screening pipeline and discovered that the stromal cells conferred anthracycline resistance to BCR-ABL1+ chronic myeloid leukaemia. We further investigated the mechanism of chemoresistance, paving the way to design the most effective therapeutic approach for these patients. |
| first_indexed | 2025-11-14T11:44:08Z |
| format | Thesis |
| id | curtin-20.500.11937-95307 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:44:08Z |
| publishDate | 2024 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-953072024-06-10T06:19:17Z Establishing a Bioluminescent Screening Platform to Identify Stromal-Mediated Chemoresistance in Leukaemia Panting, Rhiannon The tumour microenvironment has been shown to support cancer progression and regulate responsiveness to drug treatment. In leukaemia, chemoresistance is often facilitated by stromal cells of the bone marrow microenvironment. In this project, we established a co-culture drug screening pipeline and discovered that the stromal cells conferred anthracycline resistance to BCR-ABL1+ chronic myeloid leukaemia. We further investigated the mechanism of chemoresistance, paving the way to design the most effective therapeutic approach for these patients. 2024 Thesis http://hdl.handle.net/20.500.11937/95307 Curtin University restricted |
| spellingShingle | Panting, Rhiannon Establishing a Bioluminescent Screening Platform to Identify Stromal-Mediated Chemoresistance in Leukaemia |
| title | Establishing a Bioluminescent Screening Platform to Identify Stromal-Mediated Chemoresistance in Leukaemia |
| title_full | Establishing a Bioluminescent Screening Platform to Identify Stromal-Mediated Chemoresistance in Leukaemia |
| title_fullStr | Establishing a Bioluminescent Screening Platform to Identify Stromal-Mediated Chemoresistance in Leukaemia |
| title_full_unstemmed | Establishing a Bioluminescent Screening Platform to Identify Stromal-Mediated Chemoresistance in Leukaemia |
| title_short | Establishing a Bioluminescent Screening Platform to Identify Stromal-Mediated Chemoresistance in Leukaemia |
| title_sort | establishing a bioluminescent screening platform to identify stromal-mediated chemoresistance in leukaemia |
| url | http://hdl.handle.net/20.500.11937/95307 |