Cord blood 25-hydroxyvitamin D3 and allergic disease during infancy
OBJECTIVE: There has been growing interest in vitamin D insufficiency as a predisposing factor for allergy development based on immunoregulatory properties and epidemiological studies. The aim of this study was to investigate the association between vitamin D exposure in utero and allergic outcomes...
| Main Authors: | , , , |
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| Format: | Journal Article |
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2012
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| Online Access: | http://hdl.handle.net/20.500.11937/9495 |
| _version_ | 1848745966487732224 |
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| author | Jones, A. Palmer, D. Zhang, Guicheng Prescott, S. |
| author_facet | Jones, A. Palmer, D. Zhang, Guicheng Prescott, S. |
| author_sort | Jones, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | OBJECTIVE: There has been growing interest in vitamin D insufficiency as a predisposing factor for allergy development based on immunoregulatory properties and epidemiological studies. The aim of this study was to investigate the association between vitamin D exposure in utero and allergic outcomes in the first year of life. METHODS: Cord blood (CB) vitamin D was measured in 231 high-risk infants froman Australian prospective birth cohort. CB 25-hydroxyvitamin D3 (25[OH]D3) concentration was analyzed in relation to maternal vitamin D intake and the development of infant eczema, allergen sensitization, and immunoglobulin E-mediated food allergy. RESULTS: Maternal intake of supplemental vitamin D was significantly correlated with CB 25(OH)D3 concentration (r = 0.244, P = .003), whereas dietary vitamin D did not influence CB levels. There was significant seasonal variation in CB 25(OH)D3 concentration suggesting that sunlight exposure was an important determinant. Lower CB vitamin D status was observed in infants that developed eczema (P = .018), and eczema was significantly more likely in those with concentrations <50 nmol/L in comparison with those with concentrations =75 nmol/L (odds ratio 2.66; 95% confidence interval 1.24-5.72; P = .012). This association remained significant after adjustment for multiple confounding factors. The associations between CB 25(OH)D3 concentration and allergen sensitization, immunoglobulin E-mediated food allergy, and eczema severity (SCORing Atopic Dermatitis) were not significant. CONCLUSIONS: Reduced vitamin D status in pregnancy may be a risk factor for the development of eczema in the fi rst year of life, reinforcing the need to explore the role of vitamin D exposure during development for disease prevention. Copyright © 2012 by the American Academy of Pediatrics. |
| first_indexed | 2025-11-14T06:25:45Z |
| format | Journal Article |
| id | curtin-20.500.11937-9495 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:25:45Z |
| publishDate | 2012 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-94952017-09-13T14:52:44Z Cord blood 25-hydroxyvitamin D3 and allergic disease during infancy Jones, A. Palmer, D. Zhang, Guicheng Prescott, S. OBJECTIVE: There has been growing interest in vitamin D insufficiency as a predisposing factor for allergy development based on immunoregulatory properties and epidemiological studies. The aim of this study was to investigate the association between vitamin D exposure in utero and allergic outcomes in the first year of life. METHODS: Cord blood (CB) vitamin D was measured in 231 high-risk infants froman Australian prospective birth cohort. CB 25-hydroxyvitamin D3 (25[OH]D3) concentration was analyzed in relation to maternal vitamin D intake and the development of infant eczema, allergen sensitization, and immunoglobulin E-mediated food allergy. RESULTS: Maternal intake of supplemental vitamin D was significantly correlated with CB 25(OH)D3 concentration (r = 0.244, P = .003), whereas dietary vitamin D did not influence CB levels. There was significant seasonal variation in CB 25(OH)D3 concentration suggesting that sunlight exposure was an important determinant. Lower CB vitamin D status was observed in infants that developed eczema (P = .018), and eczema was significantly more likely in those with concentrations <50 nmol/L in comparison with those with concentrations =75 nmol/L (odds ratio 2.66; 95% confidence interval 1.24-5.72; P = .012). This association remained significant after adjustment for multiple confounding factors. The associations between CB 25(OH)D3 concentration and allergen sensitization, immunoglobulin E-mediated food allergy, and eczema severity (SCORing Atopic Dermatitis) were not significant. CONCLUSIONS: Reduced vitamin D status in pregnancy may be a risk factor for the development of eczema in the fi rst year of life, reinforcing the need to explore the role of vitamin D exposure during development for disease prevention. Copyright © 2012 by the American Academy of Pediatrics. 2012 Journal Article http://hdl.handle.net/20.500.11937/9495 10.1542/peds.2012-1172 unknown |
| spellingShingle | Jones, A. Palmer, D. Zhang, Guicheng Prescott, S. Cord blood 25-hydroxyvitamin D3 and allergic disease during infancy |
| title | Cord blood 25-hydroxyvitamin D3 and allergic disease during infancy |
| title_full | Cord blood 25-hydroxyvitamin D3 and allergic disease during infancy |
| title_fullStr | Cord blood 25-hydroxyvitamin D3 and allergic disease during infancy |
| title_full_unstemmed | Cord blood 25-hydroxyvitamin D3 and allergic disease during infancy |
| title_short | Cord blood 25-hydroxyvitamin D3 and allergic disease during infancy |
| title_sort | cord blood 25-hydroxyvitamin d3 and allergic disease during infancy |
| url | http://hdl.handle.net/20.500.11937/9495 |