Defining the Roles of Presenilin-1 and Presenilin-2 in Aβ Metabolism
Therapeutics targeting beta amyloid build up in the brain have shown some clinical benefits in Alzheimer’s disease. Further insights into such drug targets is required to improve clinical outcomes. This thesis provided novel, mechanistic insights into how proteins called Presenilins generate and rem...
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| Format: | Thesis |
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Curtin University
2023
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| Online Access: | http://hdl.handle.net/20.500.11937/94866 |
| _version_ | 1848765939045105664 |
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| author | Eccles, Melissa Kelly |
| author_facet | Eccles, Melissa Kelly |
| author_sort | Eccles, Melissa Kelly |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Therapeutics targeting beta amyloid build up in the brain have shown some clinical benefits in Alzheimer’s disease. Further insights into such drug targets is required to improve clinical outcomes. This thesis provided novel, mechanistic insights into how proteins called Presenilins generate and remove beta amyloid. The findings provide the foundation to pursue the Presenilins as drug targets for Alzheimer’s disease to reduce the production and improve removal of beta amyloid from the brain. |
| first_indexed | 2025-11-14T11:43:13Z |
| format | Thesis |
| id | curtin-20.500.11937-94866 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:43:13Z |
| publishDate | 2023 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-948662024-04-18T00:48:20Z Defining the Roles of Presenilin-1 and Presenilin-2 in Aβ Metabolism Eccles, Melissa Kelly Therapeutics targeting beta amyloid build up in the brain have shown some clinical benefits in Alzheimer’s disease. Further insights into such drug targets is required to improve clinical outcomes. This thesis provided novel, mechanistic insights into how proteins called Presenilins generate and remove beta amyloid. The findings provide the foundation to pursue the Presenilins as drug targets for Alzheimer’s disease to reduce the production and improve removal of beta amyloid from the brain. 2023 Thesis http://hdl.handle.net/20.500.11937/94866 Curtin University fulltext |
| spellingShingle | Eccles, Melissa Kelly Defining the Roles of Presenilin-1 and Presenilin-2 in Aβ Metabolism |
| title | Defining the Roles of Presenilin-1 and Presenilin-2
in Aβ Metabolism |
| title_full | Defining the Roles of Presenilin-1 and Presenilin-2
in Aβ Metabolism |
| title_fullStr | Defining the Roles of Presenilin-1 and Presenilin-2
in Aβ Metabolism |
| title_full_unstemmed | Defining the Roles of Presenilin-1 and Presenilin-2
in Aβ Metabolism |
| title_short | Defining the Roles of Presenilin-1 and Presenilin-2
in Aβ Metabolism |
| title_sort | defining the roles of presenilin-1 and presenilin-2
in aβ metabolism |
| url | http://hdl.handle.net/20.500.11937/94866 |