Using optical coherence tomography and optical coherence tomography angiography to delineate neurovascular homeostasis in migraine: a review
Migraine is one of the world’s most debilitating disorders, and it has recently been shown that changes in the retina can be a potential biomarker for the disease. These changes can be detected by optical coherence tomography (OCT), which measures retinal thickness, and optical coherence tomogr...
| Main Authors: | , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
Frontiers Media
2024
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/94861 |
| _version_ | 1848765937603313664 |
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| author | Chaliha, Devahuti Vaccarezza, Mauro Charng, Jason Chen, Fred K Lim, Amy Drummond, Peter Takechi, Ryusuke Lam, Virginie Dhaliwal, Satvinder S Mamo, John |
| author2 | Yoshimoto, Takeshi |
| author_facet | Yoshimoto, Takeshi Chaliha, Devahuti Vaccarezza, Mauro Charng, Jason Chen, Fred K Lim, Amy Drummond, Peter Takechi, Ryusuke Lam, Virginie Dhaliwal, Satvinder S Mamo, John |
| author_sort | Chaliha, Devahuti |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Migraine is one of the world’s most debilitating disorders, and it has recently
been shown that changes in the retina can be a potential biomarker for the
disease. These changes can be detected by optical coherence tomography
(OCT), which measures retinal thickness, and optical coherence tomography
angiography (OCTA), which measures vessel density. We searched the
databases Google Scholar, ProQuest, Scopus, and Web of Science for studies
in English using OCT and OCTA in migraineurs, using the search terms “optical
coherence tomography,” “OCT,” “optical coherence tomography angiography,”
“OCTA” and “migraine.” We found 73 primary studies, 11 reviews, and 8 metaanalyses pertaining to OCT and OCTA findings in migraineurs. They showed
that migraineurs had reduced retinal thickness (via OCT), retinal vessel density,
and greater foveal avascular zone area (via OCTA) than controls. OCTA changes
reflect a perfusion compromise occurring in migraineurs as opposed to in
healthy controls. OCT and OCTA deficits were worse in migraine-with-aura and
chronic migraine than in migraine-without-aura and episodic migraine. Certain
areas of the eye, such as the fovea, may be more vulnerable to these perfusion
changes than other parts. Direct comparison between study findings is difficult
because of the heterogeneity between the studies in terms of both methodology
and analysis. Moreover, as almost all case–control studies were cross-sectional,
more longitudinal cohort studies are needed to determine cause and effect
between migraine pathophysiology and OCT/OCTA findings. Current evidence
suggests both OCT and OCTA may serve as retinal markers for migraineurs,
and further research in this field will hopefully enable us to better understand
the vascular changes associated with migraine, perhaps also providing a new
diagnostic and therapeutic biomarker. |
| first_indexed | 2025-11-14T11:43:11Z |
| format | Journal Article |
| id | curtin-20.500.11937-94861 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:43:11Z |
| publishDate | 2024 |
| publisher | Frontiers Media |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-948612024-05-24T07:28:33Z Using optical coherence tomography and optical coherence tomography angiography to delineate neurovascular homeostasis in migraine: a review Chaliha, Devahuti Vaccarezza, Mauro Charng, Jason Chen, Fred K Lim, Amy Drummond, Peter Takechi, Ryusuke Lam, Virginie Dhaliwal, Satvinder S Mamo, John Yoshimoto, Takeshi optical coherence tomography optical coherence tomography angiography (OCTA) migraine retina choroid vasculature vasodilation vasoconstriction Migraine is one of the world’s most debilitating disorders, and it has recently been shown that changes in the retina can be a potential biomarker for the disease. These changes can be detected by optical coherence tomography (OCT), which measures retinal thickness, and optical coherence tomography angiography (OCTA), which measures vessel density. We searched the databases Google Scholar, ProQuest, Scopus, and Web of Science for studies in English using OCT and OCTA in migraineurs, using the search terms “optical coherence tomography,” “OCT,” “optical coherence tomography angiography,” “OCTA” and “migraine.” We found 73 primary studies, 11 reviews, and 8 metaanalyses pertaining to OCT and OCTA findings in migraineurs. They showed that migraineurs had reduced retinal thickness (via OCT), retinal vessel density, and greater foveal avascular zone area (via OCTA) than controls. OCTA changes reflect a perfusion compromise occurring in migraineurs as opposed to in healthy controls. OCT and OCTA deficits were worse in migraine-with-aura and chronic migraine than in migraine-without-aura and episodic migraine. Certain areas of the eye, such as the fovea, may be more vulnerable to these perfusion changes than other parts. Direct comparison between study findings is difficult because of the heterogeneity between the studies in terms of both methodology and analysis. Moreover, as almost all case–control studies were cross-sectional, more longitudinal cohort studies are needed to determine cause and effect between migraine pathophysiology and OCT/OCTA findings. Current evidence suggests both OCT and OCTA may serve as retinal markers for migraineurs, and further research in this field will hopefully enable us to better understand the vascular changes associated with migraine, perhaps also providing a new diagnostic and therapeutic biomarker. 2024 Journal Article http://hdl.handle.net/20.500.11937/94861 10.3389/fnins.2024.1376282 English http://creativecommons.org/licenses/by/4.0/ Frontiers Media fulltext |
| spellingShingle | optical coherence tomography optical coherence tomography angiography (OCTA) migraine retina choroid vasculature vasodilation vasoconstriction Chaliha, Devahuti Vaccarezza, Mauro Charng, Jason Chen, Fred K Lim, Amy Drummond, Peter Takechi, Ryusuke Lam, Virginie Dhaliwal, Satvinder S Mamo, John Using optical coherence tomography and optical coherence tomography angiography to delineate neurovascular homeostasis in migraine: a review |
| title | Using optical coherence tomography and optical coherence tomography angiography to delineate neurovascular homeostasis in migraine: a review |
| title_full | Using optical coherence tomography and optical coherence tomography angiography to delineate neurovascular homeostasis in migraine: a review |
| title_fullStr | Using optical coherence tomography and optical coherence tomography angiography to delineate neurovascular homeostasis in migraine: a review |
| title_full_unstemmed | Using optical coherence tomography and optical coherence tomography angiography to delineate neurovascular homeostasis in migraine: a review |
| title_short | Using optical coherence tomography and optical coherence tomography angiography to delineate neurovascular homeostasis in migraine: a review |
| title_sort | using optical coherence tomography and optical coherence tomography angiography to delineate neurovascular homeostasis in migraine: a review |
| topic | optical coherence tomography optical coherence tomography angiography (OCTA) migraine retina choroid vasculature vasodilation vasoconstriction |
| url | http://hdl.handle.net/20.500.11937/94861 |