The Role of Amyloidogenic Peptides in Disruption of Insulin Secretion and Action
Type 2 Diabetes and Alzheimer's Disease share many common features, including one examined in this thesis: the build-up of proteins into toxic plaque in vital organs. The thesis found that two such proteins, called Amylin and Beta-amyloid, together disrupt the health and function of pancreatic...
| Main Author: | |
|---|---|
| Format: | Thesis |
| Published: |
Curtin University
2023
|
| Online Access: | http://hdl.handle.net/20.500.11937/94806 |
| _version_ | 1848765929204219904 |
|---|---|
| author | Rowles, Joanne Elizabeth |
| author_facet | Rowles, Joanne Elizabeth |
| author_sort | Rowles, Joanne Elizabeth |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Type 2 Diabetes and Alzheimer's Disease share many common features, including one examined in this thesis: the build-up of proteins into toxic plaque in vital organs. The thesis found that two such proteins, called Amylin and Beta-amyloid, together disrupt the health and function of pancreatic cells that produce insulin and the function of muscle cells. The novel findings provide fundamental insight into how these chronic diseases are linked, which is critical for developing novel therapeutics. |
| first_indexed | 2025-11-14T11:43:03Z |
| format | Thesis |
| id | curtin-20.500.11937-94806 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:43:03Z |
| publishDate | 2023 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-948062024-04-10T02:08:57Z The Role of Amyloidogenic Peptides in Disruption of Insulin Secretion and Action Rowles, Joanne Elizabeth Type 2 Diabetes and Alzheimer's Disease share many common features, including one examined in this thesis: the build-up of proteins into toxic plaque in vital organs. The thesis found that two such proteins, called Amylin and Beta-amyloid, together disrupt the health and function of pancreatic cells that produce insulin and the function of muscle cells. The novel findings provide fundamental insight into how these chronic diseases are linked, which is critical for developing novel therapeutics. 2023 Thesis http://hdl.handle.net/20.500.11937/94806 Curtin University fulltext |
| spellingShingle | Rowles, Joanne Elizabeth The Role of Amyloidogenic Peptides in Disruption of Insulin Secretion and Action |
| title | The Role of Amyloidogenic Peptides in Disruption of Insulin Secretion and Action |
| title_full | The Role of Amyloidogenic Peptides in Disruption of Insulin Secretion and Action |
| title_fullStr | The Role of Amyloidogenic Peptides in Disruption of Insulin Secretion and Action |
| title_full_unstemmed | The Role of Amyloidogenic Peptides in Disruption of Insulin Secretion and Action |
| title_short | The Role of Amyloidogenic Peptides in Disruption of Insulin Secretion and Action |
| title_sort | role of amyloidogenic peptides in disruption of insulin secretion and action |
| url | http://hdl.handle.net/20.500.11937/94806 |