Respiratory Health Effects of In Vivo Sub-Chronic Diesel and Biodiesel Exhaust Exposure
Biodiesel, which can be made from a variety of natural oils, is currently promoted as a sustainable, healthier replacement for commercial mineral diesel despite little experimental data supporting this. The aim of our research was to investigate the health impacts of exposure to exhaust generated by...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2023
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| Online Access: | http://purl.org/au-research/grants/arc/DP170104346 http://hdl.handle.net/20.500.11937/94725 |
| _version_ | 1848765906229919744 |
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| author | Landwehr, K.R. Mead-Hunter, Ryan O’Leary, R.A. Kicic, Anthony Mullins, Ben Larcombe, Alexander |
| author_facet | Landwehr, K.R. Mead-Hunter, Ryan O’Leary, R.A. Kicic, Anthony Mullins, Ben Larcombe, Alexander |
| author_sort | Landwehr, K.R. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Biodiesel, which can be made from a variety of natural oils, is currently promoted as a sustainable, healthier replacement for commercial mineral diesel despite little experimental data supporting this. The aim of our research was to investigate the health impacts of exposure to exhaust generated by the combustion of diesel and two different biodiesels. Male BALB/c mice (n = 24 per group) were exposed for 2 h/day for 8 days to diluted exhaust from a diesel engine running on ultra-low sulfur diesel (ULSD) or Tallow or Canola biodiesel, with room air exposures used as control. A variety of respiratory-related end-point measurements were assessed, including lung function, responsiveness to methacholine, airway inflammation and cytokine response, and airway morphometry. Exposure to Tallow biodiesel exhaust resulted in the most significant health impacts compared to Air controls, including increased airway hyperresponsiveness and airway inflammation. In contrast, exposure to Canola biodiesel exhaust resulted in fewer negative health effects. Exposure to ULSD resulted in health impacts between those of the two biodiesels. The health effects of biodiesel exhaust exposure vary depending on the feedstock used to make the fuel. |
| first_indexed | 2025-11-14T11:42:41Z |
| format | Journal Article |
| id | curtin-20.500.11937-94725 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:42:41Z |
| publishDate | 2023 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-947252024-04-16T06:20:58Z Respiratory Health Effects of In Vivo Sub-Chronic Diesel and Biodiesel Exhaust Exposure Landwehr, K.R. Mead-Hunter, Ryan O’Leary, R.A. Kicic, Anthony Mullins, Ben Larcombe, Alexander biodiesel diesel exhaust exposure health impact of exhaust exposure in vivo exposure model respiratory health Male Mice Animals Air Pollutants Biofuels Particulate Matter Vehicle Emissions Sulfur Inflammation Animals Mice Inflammation Sulfur Air Pollutants Vehicle Emissions Male Particulate Matter Biofuels Biodiesel, which can be made from a variety of natural oils, is currently promoted as a sustainable, healthier replacement for commercial mineral diesel despite little experimental data supporting this. The aim of our research was to investigate the health impacts of exposure to exhaust generated by the combustion of diesel and two different biodiesels. Male BALB/c mice (n = 24 per group) were exposed for 2 h/day for 8 days to diluted exhaust from a diesel engine running on ultra-low sulfur diesel (ULSD) or Tallow or Canola biodiesel, with room air exposures used as control. A variety of respiratory-related end-point measurements were assessed, including lung function, responsiveness to methacholine, airway inflammation and cytokine response, and airway morphometry. Exposure to Tallow biodiesel exhaust resulted in the most significant health impacts compared to Air controls, including increased airway hyperresponsiveness and airway inflammation. In contrast, exposure to Canola biodiesel exhaust resulted in fewer negative health effects. Exposure to ULSD resulted in health impacts between those of the two biodiesels. The health effects of biodiesel exhaust exposure vary depending on the feedstock used to make the fuel. 2023 Journal Article http://hdl.handle.net/20.500.11937/94725 10.3390/ijms24065130 eng http://purl.org/au-research/grants/arc/DP170104346 http://creativecommons.org/licenses/by/4.0/ fulltext |
| spellingShingle | biodiesel diesel exhaust exposure health impact of exhaust exposure in vivo exposure model respiratory health Male Mice Animals Air Pollutants Biofuels Particulate Matter Vehicle Emissions Sulfur Inflammation Animals Mice Inflammation Sulfur Air Pollutants Vehicle Emissions Male Particulate Matter Biofuels Landwehr, K.R. Mead-Hunter, Ryan O’Leary, R.A. Kicic, Anthony Mullins, Ben Larcombe, Alexander Respiratory Health Effects of In Vivo Sub-Chronic Diesel and Biodiesel Exhaust Exposure |
| title | Respiratory Health Effects of In Vivo Sub-Chronic Diesel and Biodiesel Exhaust Exposure |
| title_full | Respiratory Health Effects of In Vivo Sub-Chronic Diesel and Biodiesel Exhaust Exposure |
| title_fullStr | Respiratory Health Effects of In Vivo Sub-Chronic Diesel and Biodiesel Exhaust Exposure |
| title_full_unstemmed | Respiratory Health Effects of In Vivo Sub-Chronic Diesel and Biodiesel Exhaust Exposure |
| title_short | Respiratory Health Effects of In Vivo Sub-Chronic Diesel and Biodiesel Exhaust Exposure |
| title_sort | respiratory health effects of in vivo sub-chronic diesel and biodiesel exhaust exposure |
| topic | biodiesel diesel exhaust exposure health impact of exhaust exposure in vivo exposure model respiratory health Male Mice Animals Air Pollutants Biofuels Particulate Matter Vehicle Emissions Sulfur Inflammation Animals Mice Inflammation Sulfur Air Pollutants Vehicle Emissions Male Particulate Matter Biofuels |
| url | http://purl.org/au-research/grants/arc/DP170104346 http://hdl.handle.net/20.500.11937/94725 |