Genetic association of preeclampsia to the inflammatory response gene SEPS1
Objective: The objective of the study was to test for a genetic association between the G-105A promoter polymorphism of the inflammatory mediator Selenoprotein S (SEPS1) and preeclampsia. Study Design: A retrospective study in a large Norwegian case-control cohort compared maternal genotype and alle...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
Mosby, Inc.
2008
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| Online Access: | http://hdl.handle.net/20.500.11937/9411 |
| _version_ | 1848745942655696896 |
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| author | Moses, Eric Johnson, M. Tømmerdal, L. Forsmo, S. Curran, J. Abraham, L. Charlesworth, J. Brennecke, S. Blangero, J. Austgulen, R. |
| author_facet | Moses, Eric Johnson, M. Tømmerdal, L. Forsmo, S. Curran, J. Abraham, L. Charlesworth, J. Brennecke, S. Blangero, J. Austgulen, R. |
| author_sort | Moses, Eric |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objective: The objective of the study was to test for a genetic association between the G-105A promoter polymorphism of the inflammatory mediator Selenoprotein S (SEPS1) and preeclampsia. Study Design: A retrospective study in a large Norwegian case-control cohort compared maternal genotype and allele frequencies of the SEPS1 g.-105G>A polymorphism genotyped by SNPlex assay in preeclamptic (n = 1139) and control (n = 2269) women. Statistical significance was determined by ?2 and multivariate regression analyses. Results: Women with preeclampsia were 1.34 times more likely to have the GA or AA genotype (P = .0039; 95% confidence interval [CI] 1.09 to 1.64) and 1.22 times more likely to carry the A allele (P = .023; odds ratio, 1.22; 95% CI, 1.02 to 1.46). Conclusion: The A allele of the SEPS1-105G>A polymorphism is a significant risk factor for preeclampsia in this population. © 2008 Mosby, Inc. All rights reserved. |
| first_indexed | 2025-11-14T06:25:22Z |
| format | Journal Article |
| id | curtin-20.500.11937-9411 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:25:22Z |
| publishDate | 2008 |
| publisher | Mosby, Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-94112017-09-13T14:49:27Z Genetic association of preeclampsia to the inflammatory response gene SEPS1 Moses, Eric Johnson, M. Tømmerdal, L. Forsmo, S. Curran, J. Abraham, L. Charlesworth, J. Brennecke, S. Blangero, J. Austgulen, R. Objective: The objective of the study was to test for a genetic association between the G-105A promoter polymorphism of the inflammatory mediator Selenoprotein S (SEPS1) and preeclampsia. Study Design: A retrospective study in a large Norwegian case-control cohort compared maternal genotype and allele frequencies of the SEPS1 g.-105G>A polymorphism genotyped by SNPlex assay in preeclamptic (n = 1139) and control (n = 2269) women. Statistical significance was determined by ?2 and multivariate regression analyses. Results: Women with preeclampsia were 1.34 times more likely to have the GA or AA genotype (P = .0039; 95% confidence interval [CI] 1.09 to 1.64) and 1.22 times more likely to carry the A allele (P = .023; odds ratio, 1.22; 95% CI, 1.02 to 1.46). Conclusion: The A allele of the SEPS1-105G>A polymorphism is a significant risk factor for preeclampsia in this population. © 2008 Mosby, Inc. All rights reserved. 2008 Journal Article http://hdl.handle.net/20.500.11937/9411 10.1016/j.ajog.2007.09.024 Mosby, Inc. restricted |
| spellingShingle | Moses, Eric Johnson, M. Tømmerdal, L. Forsmo, S. Curran, J. Abraham, L. Charlesworth, J. Brennecke, S. Blangero, J. Austgulen, R. Genetic association of preeclampsia to the inflammatory response gene SEPS1 |
| title | Genetic association of preeclampsia to the inflammatory response gene SEPS1 |
| title_full | Genetic association of preeclampsia to the inflammatory response gene SEPS1 |
| title_fullStr | Genetic association of preeclampsia to the inflammatory response gene SEPS1 |
| title_full_unstemmed | Genetic association of preeclampsia to the inflammatory response gene SEPS1 |
| title_short | Genetic association of preeclampsia to the inflammatory response gene SEPS1 |
| title_sort | genetic association of preeclampsia to the inflammatory response gene seps1 |
| url | http://hdl.handle.net/20.500.11937/9411 |