Characteristics and Clinical Outcomes in Patients With Heart Failure With Preserved Ejection Fraction Compared to Heart Failure With Reduced Ejection Fraction: Insights From the VCOR Heart Failure Snapshot
Background: Heart failure is increasing in prevalence, creating a greater public health and economic burden on our health care system. With a rising proportion of hospitalisations for heart failure with preserved ejection fraction (HFpEF) compared to heart failure with reduced ejection fraction (HFr...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
ELSEVIER SCIENCE INC
2022
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| Subjects: | |
| Online Access: | http://purl.org/au-research/grants/nhmrc/1136372 http://hdl.handle.net/20.500.11937/93779 |
| _version_ | 1848765787792211968 |
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| author | Tan, C. Dinh, D. Brennan, A. Hare, D.L. Kaye, D. Lefkovits, J. Lockwood, S. Neil, C. Prior, D. Nasis, A. Wilson, A. Reid, Christopher Stub, D. Driscoll, A. |
| author_facet | Tan, C. Dinh, D. Brennan, A. Hare, D.L. Kaye, D. Lefkovits, J. Lockwood, S. Neil, C. Prior, D. Nasis, A. Wilson, A. Reid, Christopher Stub, D. Driscoll, A. |
| author_sort | Tan, C. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Heart failure is increasing in prevalence, creating a greater public health and economic burden on our health care system. With a rising proportion of hospitalisations for heart failure with preserved ejection fraction (HFpEF) compared to heart failure with reduced ejection fraction (HFrEF) and lack of proven therapies for HFpEF, patient characterisation and defining clinical outcomes are important in determining optimal management of heart failure patients. There is scarce Australian-specific data with regards to the burden of disease of patients with HFpEF which further limits our ability to appropriately manage this syndrome. Aim: To determine the characteristics, management practices and outcomes of patients with HFpEF compared to patients diagnosed with HFrEF. Method: Data was sourced from the Victorian Cardiac Outcomes Registry-Heart Failure (VCOR-HF) snapshot of patients admitted with acute heart failure to one of 16 Victorian health services between 2014–2017 over one consecutive month annually. Outcomes measured were in-hospital mortality, and 30-day readmission and mortality. Results: Of the 1,132 HF patients, 436 patients were diagnosed with HFpEF and were more likely to be female (59%) and older (81.5±9.8 vs 73.2±14.5 years). They were also more likely to have hypertension (80%), atrial fibrillation (59.9%), chronic obstructive airways disease (36.2%) and chronic kidney disease (68.8%). Patients with HFrEF were more likely to have ischaemic heart disease with a history of previous myocardial infarction (36.6%), percutaneous coronary intervention and cardiac bypass surgery (35.2%). There were no significant differences in 30-day mortality between HFpEF and HFrEF (10.2% vs 7.8%; p=0.19, respectively) and 30-day readmission rates (22.1% vs 25.9%; p=0.15, respectively). Conclusion: VCOR-HF Snapshot data provides important insight into the burden of acute heart failure. Whilst patients with HFpEF and HFrEF have differing clinical profiles, morbidity, mortality and re-admission rates are similar. |
| first_indexed | 2025-11-14T11:40:48Z |
| format | Journal Article |
| id | curtin-20.500.11937-93779 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:40:48Z |
| publishDate | 2022 |
| publisher | ELSEVIER SCIENCE INC |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-937792024-01-09T07:54:56Z Characteristics and Clinical Outcomes in Patients With Heart Failure With Preserved Ejection Fraction Compared to Heart Failure With Reduced Ejection Fraction: Insights From the VCOR Heart Failure Snapshot Tan, C. Dinh, D. Brennan, A. Hare, D.L. Kaye, D. Lefkovits, J. Lockwood, S. Neil, C. Prior, D. Nasis, A. Wilson, A. Reid, Christopher Stub, D. Driscoll, A. Science & Technology Life Sciences & Biomedicine Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Heart failure Heart failure with preserved ejection fraction Acute heart failure Mortality Readmission SYSTOLIC FUNCTION POPULATION PREVALENCE THERAPIES TRENDS Acute heart failure Heart failure Heart failure with preserved ejection fraction Mortality Readmission Australia Female Heart Failure Humans Male Prognosis Stroke Volume Ventricular Dysfunction, Left Ventricular Function, Left Humans Ventricular Dysfunction, Left Stroke Volume Prognosis Ventricular Function, Left Australia Female Male Heart Failure Background: Heart failure is increasing in prevalence, creating a greater public health and economic burden on our health care system. With a rising proportion of hospitalisations for heart failure with preserved ejection fraction (HFpEF) compared to heart failure with reduced ejection fraction (HFrEF) and lack of proven therapies for HFpEF, patient characterisation and defining clinical outcomes are important in determining optimal management of heart failure patients. There is scarce Australian-specific data with regards to the burden of disease of patients with HFpEF which further limits our ability to appropriately manage this syndrome. Aim: To determine the characteristics, management practices and outcomes of patients with HFpEF compared to patients diagnosed with HFrEF. Method: Data was sourced from the Victorian Cardiac Outcomes Registry-Heart Failure (VCOR-HF) snapshot of patients admitted with acute heart failure to one of 16 Victorian health services between 2014–2017 over one consecutive month annually. Outcomes measured were in-hospital mortality, and 30-day readmission and mortality. Results: Of the 1,132 HF patients, 436 patients were diagnosed with HFpEF and were more likely to be female (59%) and older (81.5±9.8 vs 73.2±14.5 years). They were also more likely to have hypertension (80%), atrial fibrillation (59.9%), chronic obstructive airways disease (36.2%) and chronic kidney disease (68.8%). Patients with HFrEF were more likely to have ischaemic heart disease with a history of previous myocardial infarction (36.6%), percutaneous coronary intervention and cardiac bypass surgery (35.2%). There were no significant differences in 30-day mortality between HFpEF and HFrEF (10.2% vs 7.8%; p=0.19, respectively) and 30-day readmission rates (22.1% vs 25.9%; p=0.15, respectively). Conclusion: VCOR-HF Snapshot data provides important insight into the burden of acute heart failure. Whilst patients with HFpEF and HFrEF have differing clinical profiles, morbidity, mortality and re-admission rates are similar. 2022 Journal Article http://hdl.handle.net/20.500.11937/93779 10.1016/j.hlc.2021.09.019 English http://purl.org/au-research/grants/nhmrc/1136372 http://creativecommons.org/licenses/by-nc-nd/4.0/ ELSEVIER SCIENCE INC fulltext |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Heart failure Heart failure with preserved ejection fraction Acute heart failure Mortality Readmission SYSTOLIC FUNCTION POPULATION PREVALENCE THERAPIES TRENDS Acute heart failure Heart failure Heart failure with preserved ejection fraction Mortality Readmission Australia Female Heart Failure Humans Male Prognosis Stroke Volume Ventricular Dysfunction, Left Ventricular Function, Left Humans Ventricular Dysfunction, Left Stroke Volume Prognosis Ventricular Function, Left Australia Female Male Heart Failure Tan, C. Dinh, D. Brennan, A. Hare, D.L. Kaye, D. Lefkovits, J. Lockwood, S. Neil, C. Prior, D. Nasis, A. Wilson, A. Reid, Christopher Stub, D. Driscoll, A. Characteristics and Clinical Outcomes in Patients With Heart Failure With Preserved Ejection Fraction Compared to Heart Failure With Reduced Ejection Fraction: Insights From the VCOR Heart Failure Snapshot |
| title | Characteristics and Clinical Outcomes in Patients With Heart Failure With Preserved Ejection Fraction Compared to Heart Failure With Reduced Ejection Fraction: Insights From the VCOR Heart Failure Snapshot |
| title_full | Characteristics and Clinical Outcomes in Patients With Heart Failure With Preserved Ejection Fraction Compared to Heart Failure With Reduced Ejection Fraction: Insights From the VCOR Heart Failure Snapshot |
| title_fullStr | Characteristics and Clinical Outcomes in Patients With Heart Failure With Preserved Ejection Fraction Compared to Heart Failure With Reduced Ejection Fraction: Insights From the VCOR Heart Failure Snapshot |
| title_full_unstemmed | Characteristics and Clinical Outcomes in Patients With Heart Failure With Preserved Ejection Fraction Compared to Heart Failure With Reduced Ejection Fraction: Insights From the VCOR Heart Failure Snapshot |
| title_short | Characteristics and Clinical Outcomes in Patients With Heart Failure With Preserved Ejection Fraction Compared to Heart Failure With Reduced Ejection Fraction: Insights From the VCOR Heart Failure Snapshot |
| title_sort | characteristics and clinical outcomes in patients with heart failure with preserved ejection fraction compared to heart failure with reduced ejection fraction: insights from the vcor heart failure snapshot |
| topic | Science & Technology Life Sciences & Biomedicine Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Heart failure Heart failure with preserved ejection fraction Acute heart failure Mortality Readmission SYSTOLIC FUNCTION POPULATION PREVALENCE THERAPIES TRENDS Acute heart failure Heart failure Heart failure with preserved ejection fraction Mortality Readmission Australia Female Heart Failure Humans Male Prognosis Stroke Volume Ventricular Dysfunction, Left Ventricular Function, Left Humans Ventricular Dysfunction, Left Stroke Volume Prognosis Ventricular Function, Left Australia Female Male Heart Failure |
| url | http://purl.org/au-research/grants/nhmrc/1136372 http://hdl.handle.net/20.500.11937/93779 |