Effect of Age on Clinical Outcomes in Elderly Patients (>80 Years) Undergoing Percutaneous Coronary Intervention : Insights From a Multi-Centre Australian PCI Registry
Objectives: To evaluate the effect of age in an all-comers population undergoing percutaneous coronary intervention (PCI). Background: Age is an important consideration in determining appropriateness for invasive cardiac assessment and perceived clinical outcomes. Methods: We analysed data from 29,0...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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ELSEVIER SCIENCE INC
2021
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| Online Access: | http://purl.org/au-research/grants/nhmrc/1111170 http://hdl.handle.net/20.500.11937/93762 |
| _version_ | 1848765782733881344 |
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| author | Papapostolou, S. Dinh, D.T. Noaman, S. Biswas, S. Duffy, S.J. Stub, D. Shaw, J.A. Walton, A. Sharma, A. Brennan, A. Clark, D. Freeman, M. Yip, T. Ajani, A. Reid, Christopher Oqueli, E. Chan, W. |
| author_facet | Papapostolou, S. Dinh, D.T. Noaman, S. Biswas, S. Duffy, S.J. Stub, D. Shaw, J.A. Walton, A. Sharma, A. Brennan, A. Clark, D. Freeman, M. Yip, T. Ajani, A. Reid, Christopher Oqueli, E. Chan, W. |
| author_sort | Papapostolou, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objectives: To evaluate the effect of age in an all-comers population undergoing percutaneous coronary intervention (PCI). Background: Age is an important consideration in determining appropriateness for invasive cardiac assessment and perceived clinical outcomes. Methods: We analysed data from 29,012 consecutive patients undergoing PCI in the Melbourne Interventional Group (MIG) registry between 2005 and 2017. 25,730 patients <80 year old (78% male, mean age 62±10 years; non-elderly cohort) were compared to 3,282 patients ≥80 year old (61% male, mean age 84±3 years; elderly cohort). Results: The elderly cohort had greater prevalence of hypertension, diabetes and previous myocardial infarction (all p<0.001). Elderly patients were more likely to present with acute coronary syndromes, left ventricular ejection fraction <45% and chronic kidney disease (p<0.0001). In-hospital, 30-day and long-term all-cause mortality (over a median of 3.6 and 5.1 years for elderly and non-elderly cohorts, respectively) were higher in the elderly cohort (5.2% vs. 1.9%; 6.4% vs. 2.2%; and 43% vs. 14% respectively, all p<0.0001). In multivariate Cox regression analysis, estimated glomerular filtration rate (eGFR) <30 mL/min/1.73 m2 (HR 3.8, 95% CI: 3.4–4.3), cardiogenic shock (HR 3.0, 95% CI: 2.6–3.4), ejection fraction <30% (HR 2.5, 95% CI: 2.1–2.9); and age ≥80 years (HR 2.8, 95% CI: 2.6–3.1) were independent predictors of long-term all-cause mortality (all p<0.0001). Conclusion: The elderly cohort is a high-risk group of patients with increasing age being associated with poorer long-term mortality. Age, thus, should be an important consideration when individualising treatment in elderly patients. |
| first_indexed | 2025-11-14T11:40:43Z |
| format | Journal Article |
| id | curtin-20.500.11937-93762 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:40:43Z |
| publishDate | 2021 |
| publisher | ELSEVIER SCIENCE INC |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-937622024-01-09T07:26:31Z Effect of Age on Clinical Outcomes in Elderly Patients (>80 Years) Undergoing Percutaneous Coronary Intervention : Insights From a Multi-Centre Australian PCI Registry Papapostolou, S. Dinh, D.T. Noaman, S. Biswas, S. Duffy, S.J. Stub, D. Shaw, J.A. Walton, A. Sharma, A. Brennan, A. Clark, D. Freeman, M. Yip, T. Ajani, A. Reid, Christopher Oqueli, E. Chan, W. Science & Technology Life Sciences & Biomedicine Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Elderly octogenarians Percutaneous coronary intervention Coronary angiography ELEVATION MYOCARDIAL-INFARCTION DRUG-ELUTING STENTS AMERICAN-HEART-ASSOCIATION LONG-TERM OUTCOMES ARTERY-DISEASE INCOMPLETE REVASCULARIZATION SCIENTIFIC STATEMENT CARDIOVASCULAR CARE GLOBAL REGISTRY BARE-METAL Coronary angiography Elderly octogenarians Percutaneous coronary intervention Aged Aged, 80 and over Australia Female Humans Male Middle Aged Percutaneous Coronary Intervention Registries Risk Factors Stroke Volume Ventricular Function, Left Melbourne Interventional Group Investigators Humans Stroke Volume Registries Risk Factors Ventricular Function, Left Aged Aged, 80 and over Middle Aged Australia Female Male Percutaneous Coronary Intervention Objectives: To evaluate the effect of age in an all-comers population undergoing percutaneous coronary intervention (PCI). Background: Age is an important consideration in determining appropriateness for invasive cardiac assessment and perceived clinical outcomes. Methods: We analysed data from 29,012 consecutive patients undergoing PCI in the Melbourne Interventional Group (MIG) registry between 2005 and 2017. 25,730 patients <80 year old (78% male, mean age 62±10 years; non-elderly cohort) were compared to 3,282 patients ≥80 year old (61% male, mean age 84±3 years; elderly cohort). Results: The elderly cohort had greater prevalence of hypertension, diabetes and previous myocardial infarction (all p<0.001). Elderly patients were more likely to present with acute coronary syndromes, left ventricular ejection fraction <45% and chronic kidney disease (p<0.0001). In-hospital, 30-day and long-term all-cause mortality (over a median of 3.6 and 5.1 years for elderly and non-elderly cohorts, respectively) were higher in the elderly cohort (5.2% vs. 1.9%; 6.4% vs. 2.2%; and 43% vs. 14% respectively, all p<0.0001). In multivariate Cox regression analysis, estimated glomerular filtration rate (eGFR) <30 mL/min/1.73 m2 (HR 3.8, 95% CI: 3.4–4.3), cardiogenic shock (HR 3.0, 95% CI: 2.6–3.4), ejection fraction <30% (HR 2.5, 95% CI: 2.1–2.9); and age ≥80 years (HR 2.8, 95% CI: 2.6–3.1) were independent predictors of long-term all-cause mortality (all p<0.0001). Conclusion: The elderly cohort is a high-risk group of patients with increasing age being associated with poorer long-term mortality. Age, thus, should be an important consideration when individualising treatment in elderly patients. 2021 Journal Article http://hdl.handle.net/20.500.11937/93762 10.1016/j.hlc.2020.12.003 English http://purl.org/au-research/grants/nhmrc/1111170 ELSEVIER SCIENCE INC restricted |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Elderly octogenarians Percutaneous coronary intervention Coronary angiography ELEVATION MYOCARDIAL-INFARCTION DRUG-ELUTING STENTS AMERICAN-HEART-ASSOCIATION LONG-TERM OUTCOMES ARTERY-DISEASE INCOMPLETE REVASCULARIZATION SCIENTIFIC STATEMENT CARDIOVASCULAR CARE GLOBAL REGISTRY BARE-METAL Coronary angiography Elderly octogenarians Percutaneous coronary intervention Aged Aged, 80 and over Australia Female Humans Male Middle Aged Percutaneous Coronary Intervention Registries Risk Factors Stroke Volume Ventricular Function, Left Melbourne Interventional Group Investigators Humans Stroke Volume Registries Risk Factors Ventricular Function, Left Aged Aged, 80 and over Middle Aged Australia Female Male Percutaneous Coronary Intervention Papapostolou, S. Dinh, D.T. Noaman, S. Biswas, S. Duffy, S.J. Stub, D. Shaw, J.A. Walton, A. Sharma, A. Brennan, A. Clark, D. Freeman, M. Yip, T. Ajani, A. Reid, Christopher Oqueli, E. Chan, W. Effect of Age on Clinical Outcomes in Elderly Patients (>80 Years) Undergoing Percutaneous Coronary Intervention : Insights From a Multi-Centre Australian PCI Registry |
| title | Effect of Age on Clinical Outcomes in Elderly Patients (>80 Years) Undergoing Percutaneous Coronary Intervention : Insights From a Multi-Centre Australian PCI Registry |
| title_full | Effect of Age on Clinical Outcomes in Elderly Patients (>80 Years) Undergoing Percutaneous Coronary Intervention : Insights From a Multi-Centre Australian PCI Registry |
| title_fullStr | Effect of Age on Clinical Outcomes in Elderly Patients (>80 Years) Undergoing Percutaneous Coronary Intervention : Insights From a Multi-Centre Australian PCI Registry |
| title_full_unstemmed | Effect of Age on Clinical Outcomes in Elderly Patients (>80 Years) Undergoing Percutaneous Coronary Intervention : Insights From a Multi-Centre Australian PCI Registry |
| title_short | Effect of Age on Clinical Outcomes in Elderly Patients (>80 Years) Undergoing Percutaneous Coronary Intervention : Insights From a Multi-Centre Australian PCI Registry |
| title_sort | effect of age on clinical outcomes in elderly patients (>80 years) undergoing percutaneous coronary intervention : insights from a multi-centre australian pci registry |
| topic | Science & Technology Life Sciences & Biomedicine Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Elderly octogenarians Percutaneous coronary intervention Coronary angiography ELEVATION MYOCARDIAL-INFARCTION DRUG-ELUTING STENTS AMERICAN-HEART-ASSOCIATION LONG-TERM OUTCOMES ARTERY-DISEASE INCOMPLETE REVASCULARIZATION SCIENTIFIC STATEMENT CARDIOVASCULAR CARE GLOBAL REGISTRY BARE-METAL Coronary angiography Elderly octogenarians Percutaneous coronary intervention Aged Aged, 80 and over Australia Female Humans Male Middle Aged Percutaneous Coronary Intervention Registries Risk Factors Stroke Volume Ventricular Function, Left Melbourne Interventional Group Investigators Humans Stroke Volume Registries Risk Factors Ventricular Function, Left Aged Aged, 80 and over Middle Aged Australia Female Male Percutaneous Coronary Intervention |
| url | http://purl.org/au-research/grants/nhmrc/1111170 http://hdl.handle.net/20.500.11937/93762 |