Overcoming resistance of targeted EGFR monotherapy by inhibition of STAT3 escape pathway in soft tissue sarcoma

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Overcoming resistance of targeted EGFR monotherapy by inhibition of STAT3 escape pathway in soft tissue sarcoma

Although epidermal growth factor receptor (EGFR) is often over-expressed in soft tissue sarcoma (STS), a phase II trial using an EGFR inhibitor gefitinib showed a low response rate. This study identified a new secondary resistance mechanism of gefitinib in STS, and developed new strategies to improv...

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Bibliographic Details
Main Authors:	Wang, X., Goldstein, D., Crowe, P., Yang, M., Garrett, K., Zeps, Nikolajs, Yang, J.
Format:	Journal Article
Published:	Impact Journals LLC 2016
Online Access:	http://hdl.handle.net/20.500.11937/9373

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