Comparative Study of Plan Robustness for Breast Radiotherapy: Volumetric Modulated Arc Therapy Plans with Robust Optimization versus Manual Flash Approach
A previous study investigated robustness of manual flash (MF) and robust optimized (RO) volumetric modulated arc therapy plans for breast radiotherapy based on five patients in 2020 and indicated that the RO was more robust than the MF, although the MF is still current standard practice. The purpose...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
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MDPI AG
2023
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| Online Access: | http://hdl.handle.net/20.500.11937/93701 |
| _version_ | 1848765767493877760 |
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| author | Chan, Ray CK Ng, Curtise Hung, Rico HM Li, Yoyo TY Tam, Yuki TY Wong, Blossom YL Yu, Jacky CK Leung, Vincent WS |
| author2 | Mozdarani, Hossein |
| author_facet | Mozdarani, Hossein Chan, Ray CK Ng, Curtise Hung, Rico HM Li, Yoyo TY Tam, Yuki TY Wong, Blossom YL Yu, Jacky CK Leung, Vincent WS |
| author_sort | Chan, Ray CK |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | A previous study investigated robustness of manual flash (MF) and robust optimized (RO) volumetric modulated arc therapy plans for breast radiotherapy based on five patients in 2020 and indicated that the RO was more robust than the MF, although the MF is still current standard practice. The purpose of this study was to compare their plan robustness in terms of dose variation to clinical target volume (CTV) and organs at risk (OARs) based on a larger sample size. This was a retrospective study involving 34 female patients. Their plan robustness was evaluated based on measured volume/dose difference between nominal and worst scenarios (ΔV/ΔD) for each CTV and OARs parameter, with a smaller difference representing greater robustness. Paired sample t-test was used to compare their robustness values. All parameters (except CTV ΔD98%) of the RO approach had smaller ΔV/ΔD values than those of the MF. Also, the RO approach had statistically significantly smaller ΔV/ΔD values (p < 0.001–0.012) for all CTV parameters except the CTV ΔV95% and ΔD98% and heart ΔDmean. This study’s results confirm that the RO approach was more robust than the MF in general. Although both techniques were able to generate clinically acceptable plans for breast radiotherapy, the RO could potentially improve workflow efficiency due to its simpler planning process. |
| first_indexed | 2025-11-14T11:40:29Z |
| format | Journal Article |
| id | curtin-20.500.11937-93701 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:40:29Z |
| publishDate | 2023 |
| publisher | MDPI AG |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-937012023-11-21T01:06:42Z Comparative Study of Plan Robustness for Breast Radiotherapy: Volumetric Modulated Arc Therapy Plans with Robust Optimization versus Manual Flash Approach Chan, Ray CK Ng, Curtise Hung, Rico HM Li, Yoyo TY Tam, Yuki TY Wong, Blossom YL Yu, Jacky CK Leung, Vincent WS Mozdarani, Hossein Cancer Chest Wall Displacement Dosimetry Error Organs at Risk Radiation Dose Radiation Therapy Skin Flash Target Volume Uncertainty A previous study investigated robustness of manual flash (MF) and robust optimized (RO) volumetric modulated arc therapy plans for breast radiotherapy based on five patients in 2020 and indicated that the RO was more robust than the MF, although the MF is still current standard practice. The purpose of this study was to compare their plan robustness in terms of dose variation to clinical target volume (CTV) and organs at risk (OARs) based on a larger sample size. This was a retrospective study involving 34 female patients. Their plan robustness was evaluated based on measured volume/dose difference between nominal and worst scenarios (ΔV/ΔD) for each CTV and OARs parameter, with a smaller difference representing greater robustness. Paired sample t-test was used to compare their robustness values. All parameters (except CTV ΔD98%) of the RO approach had smaller ΔV/ΔD values than those of the MF. Also, the RO approach had statistically significantly smaller ΔV/ΔD values (p < 0.001–0.012) for all CTV parameters except the CTV ΔV95% and ΔD98% and heart ΔDmean. This study’s results confirm that the RO approach was more robust than the MF in general. Although both techniques were able to generate clinically acceptable plans for breast radiotherapy, the RO could potentially improve workflow efficiency due to its simpler planning process. 2023 Journal Article http://hdl.handle.net/20.500.11937/93701 10.3390/diagnostics13223395 http://creativecommons.org/licenses/by/4.0/ MDPI AG fulltext |
| spellingShingle | Cancer Chest Wall Displacement Dosimetry Error Organs at Risk Radiation Dose Radiation Therapy Skin Flash Target Volume Uncertainty Chan, Ray CK Ng, Curtise Hung, Rico HM Li, Yoyo TY Tam, Yuki TY Wong, Blossom YL Yu, Jacky CK Leung, Vincent WS Comparative Study of Plan Robustness for Breast Radiotherapy: Volumetric Modulated Arc Therapy Plans with Robust Optimization versus Manual Flash Approach |
| title | Comparative Study of Plan Robustness for Breast Radiotherapy: Volumetric Modulated Arc Therapy Plans with Robust Optimization versus Manual Flash Approach |
| title_full | Comparative Study of Plan Robustness for Breast Radiotherapy: Volumetric Modulated Arc Therapy Plans with Robust Optimization versus Manual Flash Approach |
| title_fullStr | Comparative Study of Plan Robustness for Breast Radiotherapy: Volumetric Modulated Arc Therapy Plans with Robust Optimization versus Manual Flash Approach |
| title_full_unstemmed | Comparative Study of Plan Robustness for Breast Radiotherapy: Volumetric Modulated Arc Therapy Plans with Robust Optimization versus Manual Flash Approach |
| title_short | Comparative Study of Plan Robustness for Breast Radiotherapy: Volumetric Modulated Arc Therapy Plans with Robust Optimization versus Manual Flash Approach |
| title_sort | comparative study of plan robustness for breast radiotherapy: volumetric modulated arc therapy plans with robust optimization versus manual flash approach |
| topic | Cancer Chest Wall Displacement Dosimetry Error Organs at Risk Radiation Dose Radiation Therapy Skin Flash Target Volume Uncertainty |
| url | http://hdl.handle.net/20.500.11937/93701 |