The role of the HGF/c-MET signalling pathway in cellular crosstalk during chronic liver injury
The HGF/c-MET signalling pathway is known to be antifibrotic in the liver. However, its influence on liver progenitor cell (LPC) and hepatic stellate cell (HSC) communication during chronic liver disease (CLD) is unknown. Here, CRISPR/Cas9 technology was utilised to create a c-MET knockout LPC line,...
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| Format: | Thesis |
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Curtin University
2023
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| Online Access: | http://hdl.handle.net/20.500.11937/93361 |
| _version_ | 1848765726888820736 |
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| author | Pasic, Sara |
| author_facet | Pasic, Sara |
| author_sort | Pasic, Sara |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The HGF/c-MET signalling pathway is known to be antifibrotic in the liver. However, its influence on liver progenitor cell (LPC) and hepatic stellate cell (HSC) communication during chronic liver disease (CLD) is unknown. Here, CRISPR/Cas9 technology was utilised to create a c-MET knockout LPC line, which altered LPC biology and diminished the HSC-regulatory potential of LPCs. These findings suggest that HGF/c-MET signalling is important for maintaining LPC biology and regulating HSC behaviour in CLD. |
| first_indexed | 2025-11-14T11:39:50Z |
| format | Thesis |
| id | curtin-20.500.11937-93361 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:39:50Z |
| publishDate | 2023 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-933612023-09-20T00:54:38Z The role of the HGF/c-MET signalling pathway in cellular crosstalk during chronic liver injury Pasic, Sara The HGF/c-MET signalling pathway is known to be antifibrotic in the liver. However, its influence on liver progenitor cell (LPC) and hepatic stellate cell (HSC) communication during chronic liver disease (CLD) is unknown. Here, CRISPR/Cas9 technology was utilised to create a c-MET knockout LPC line, which altered LPC biology and diminished the HSC-regulatory potential of LPCs. These findings suggest that HGF/c-MET signalling is important for maintaining LPC biology and regulating HSC behaviour in CLD. 2023 Thesis http://hdl.handle.net/20.500.11937/93361 Curtin University fulltext |
| spellingShingle | Pasic, Sara The role of the HGF/c-MET signalling pathway in cellular crosstalk during chronic liver injury |
| title | The role of the HGF/c-MET signalling pathway in
cellular crosstalk during chronic liver injury |
| title_full | The role of the HGF/c-MET signalling pathway in
cellular crosstalk during chronic liver injury |
| title_fullStr | The role of the HGF/c-MET signalling pathway in
cellular crosstalk during chronic liver injury |
| title_full_unstemmed | The role of the HGF/c-MET signalling pathway in
cellular crosstalk during chronic liver injury |
| title_short | The role of the HGF/c-MET signalling pathway in
cellular crosstalk during chronic liver injury |
| title_sort | role of the hgf/c-met signalling pathway in
cellular crosstalk during chronic liver injury |
| url | http://hdl.handle.net/20.500.11937/93361 |