The risk of major structural birth defects associated with seasonal influenza vaccination during pregnancy: A population-based cohort study
Introduction: Seasonal inactivated influenza vaccine (IIV) is routinely recommended during pregnancy to protect both mothers and infants from complications following influenza infection. While previous studies have evaluated the risk of major structural birth defects in infants associated with prena...
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| Format: | Journal Article |
| Language: | English |
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WILEY
2022
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| Online Access: | http://purl.org/au-research/grants/nhmrc/1141510 http://hdl.handle.net/20.500.11937/93242 |
| _version_ | 1848765717139161088 |
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| author | Sarna, Minda Pereira, Gavin Foo, D. Baynam, G.S. Regan, Annette |
| author_facet | Sarna, Minda Pereira, Gavin Foo, D. Baynam, G.S. Regan, Annette |
| author_sort | Sarna, Minda |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Introduction: Seasonal inactivated influenza vaccine (IIV) is routinely recommended during pregnancy to protect both mothers and infants from complications following influenza infection. While previous studies have evaluated the risk of major structural birth defects in infants associated with prenatal administration of monovalent pandemic IIV, fewer studies have evaluated the risk associated with prenatal seasonal IIV. Methods: We conducted a population-based cohort study of 125,866 singleton births between 2012 and 2016 in Western Australia. Birth registrations were linked to the state's registers for congenital anomalies and a state prenatal vaccination database. We estimated prevalence ratios (PR) of any major structural birth defect and defects by organ system. Vaccinated pregnancies were defined as those with a record of IIV in the first trimester. Inverse probability treatment weighting factored for baseline probability for vaccination. A Bonferroni correction was applied to account for multiple comparisons. Results: About 3.9% of births had a major structural birth defect. Seasonal IIV exposure during the first trimester was not associated with diagnosis of any major structural birth defect diagnosed within 1 month of birth (PR 0.98, 95% CI: 0.77, 1.28) or within 6 years of life (PR 1.02, 95% CI: 0.78, 1.35). We identified no increased risk in specific birth defects associated with seasonal IIV. Conclusion: Based on registry data for up to 6 years of follow-up, results suggest there is no association between maternal influenza vaccination and risk of major structural birth defects. These results support the safety of seasonal IIV administration during pregnancy. |
| first_indexed | 2025-11-14T11:39:41Z |
| format | Journal Article |
| id | curtin-20.500.11937-93242 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:39:41Z |
| publishDate | 2022 |
| publisher | WILEY |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-932422023-10-09T08:09:30Z The risk of major structural birth defects associated with seasonal influenza vaccination during pregnancy: A population-based cohort study Sarna, Minda Pereira, Gavin Foo, D. Baynam, G.S. Regan, Annette Science & Technology Life Sciences & Biomedicine Developmental Biology Toxicology developmental anomaly influenza vaccine major birth defects maternal vaccination pregnant women PRETERM DELIVERY CONGENITAL-MALFORMATIONS DEVELOPMENTAL DYSPLASIA SPONTANEOUS-ABORTION 1ST TRIMESTER SAFETY OUTCOMES INFANTS AUSTRALIA VACCINES developmental anomaly influenza vaccine major birth defects maternal vaccination pregnant women Infant Pregnancy Female Humans Influenza, Human Cohort Studies Seasons Influenza Vaccines Vaccination Humans Influenza Vaccines Vaccination Cohort Studies Seasons Pregnancy Infant Female Influenza, Human Introduction: Seasonal inactivated influenza vaccine (IIV) is routinely recommended during pregnancy to protect both mothers and infants from complications following influenza infection. While previous studies have evaluated the risk of major structural birth defects in infants associated with prenatal administration of monovalent pandemic IIV, fewer studies have evaluated the risk associated with prenatal seasonal IIV. Methods: We conducted a population-based cohort study of 125,866 singleton births between 2012 and 2016 in Western Australia. Birth registrations were linked to the state's registers for congenital anomalies and a state prenatal vaccination database. We estimated prevalence ratios (PR) of any major structural birth defect and defects by organ system. Vaccinated pregnancies were defined as those with a record of IIV in the first trimester. Inverse probability treatment weighting factored for baseline probability for vaccination. A Bonferroni correction was applied to account for multiple comparisons. Results: About 3.9% of births had a major structural birth defect. Seasonal IIV exposure during the first trimester was not associated with diagnosis of any major structural birth defect diagnosed within 1 month of birth (PR 0.98, 95% CI: 0.77, 1.28) or within 6 years of life (PR 1.02, 95% CI: 0.78, 1.35). We identified no increased risk in specific birth defects associated with seasonal IIV. Conclusion: Based on registry data for up to 6 years of follow-up, results suggest there is no association between maternal influenza vaccination and risk of major structural birth defects. These results support the safety of seasonal IIV administration during pregnancy. 2022 Journal Article http://hdl.handle.net/20.500.11937/93242 10.1002/bdr2.2049 English http://purl.org/au-research/grants/nhmrc/1141510 http://purl.org/au-research/grants/nhmrc/1138425 http://purl.org/au-research/grants/nhmrc/1099655 http://creativecommons.org/licenses/by-nc-nd/4.0/ WILEY fulltext |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Developmental Biology Toxicology developmental anomaly influenza vaccine major birth defects maternal vaccination pregnant women PRETERM DELIVERY CONGENITAL-MALFORMATIONS DEVELOPMENTAL DYSPLASIA SPONTANEOUS-ABORTION 1ST TRIMESTER SAFETY OUTCOMES INFANTS AUSTRALIA VACCINES developmental anomaly influenza vaccine major birth defects maternal vaccination pregnant women Infant Pregnancy Female Humans Influenza, Human Cohort Studies Seasons Influenza Vaccines Vaccination Humans Influenza Vaccines Vaccination Cohort Studies Seasons Pregnancy Infant Female Influenza, Human Sarna, Minda Pereira, Gavin Foo, D. Baynam, G.S. Regan, Annette The risk of major structural birth defects associated with seasonal influenza vaccination during pregnancy: A population-based cohort study |
| title | The risk of major structural birth defects associated with seasonal influenza vaccination during pregnancy: A population-based cohort study |
| title_full | The risk of major structural birth defects associated with seasonal influenza vaccination during pregnancy: A population-based cohort study |
| title_fullStr | The risk of major structural birth defects associated with seasonal influenza vaccination during pregnancy: A population-based cohort study |
| title_full_unstemmed | The risk of major structural birth defects associated with seasonal influenza vaccination during pregnancy: A population-based cohort study |
| title_short | The risk of major structural birth defects associated with seasonal influenza vaccination during pregnancy: A population-based cohort study |
| title_sort | risk of major structural birth defects associated with seasonal influenza vaccination during pregnancy: a population-based cohort study |
| topic | Science & Technology Life Sciences & Biomedicine Developmental Biology Toxicology developmental anomaly influenza vaccine major birth defects maternal vaccination pregnant women PRETERM DELIVERY CONGENITAL-MALFORMATIONS DEVELOPMENTAL DYSPLASIA SPONTANEOUS-ABORTION 1ST TRIMESTER SAFETY OUTCOMES INFANTS AUSTRALIA VACCINES developmental anomaly influenza vaccine major birth defects maternal vaccination pregnant women Infant Pregnancy Female Humans Influenza, Human Cohort Studies Seasons Influenza Vaccines Vaccination Humans Influenza Vaccines Vaccination Cohort Studies Seasons Pregnancy Infant Female Influenza, Human |
| url | http://purl.org/au-research/grants/nhmrc/1141510 http://purl.org/au-research/grants/nhmrc/1141510 http://purl.org/au-research/grants/nhmrc/1141510 http://hdl.handle.net/20.500.11937/93242 |