Associations between interpregnancy interval and preterm birth by previous preterm birth status in four high-income countries: a cohort study
Objective: To investigate the effect of interpregnancy interval (IPI) on preterm birth (PTB) according to whether the previous birth was preterm or term. Design: Cohort study. Setting: USA (California), Australia, Finland, Norway (1980–2017). Population: Women who gave birth to first and second (n =...
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| Format: | Journal Article |
| Language: | English |
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WILEY
2021
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| Online Access: | http://purl.org/au-research/grants/nhmrc/1138425 http://hdl.handle.net/20.500.11937/93241 |
| _version_ | 1848765716844511232 |
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| author | Marinovich, Luke Regan, Annette Gissler, M. Magnus, M.C. Håberg, S.E. Mayo, J.A. Shaw, G.M. Bell, J. Nassar, N. Ball, Stephen Gebremedhin, Amanuel Marston, C. de Klerk, N. Betrán, A.P. Padula, A.M. Pereira, Gavin |
| author_facet | Marinovich, Luke Regan, Annette Gissler, M. Magnus, M.C. Håberg, S.E. Mayo, J.A. Shaw, G.M. Bell, J. Nassar, N. Ball, Stephen Gebremedhin, Amanuel Marston, C. de Klerk, N. Betrán, A.P. Padula, A.M. Pereira, Gavin |
| author_sort | Marinovich, Luke |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objective: To investigate the effect of interpregnancy interval (IPI) on preterm birth (PTB) according to whether the previous birth was preterm or term. Design: Cohort study. Setting: USA (California), Australia, Finland, Norway (1980–2017). Population: Women who gave birth to first and second (n = 3 213 855) singleton livebirths. Methods: Odds ratios (ORs) for PTB according to IPIs were modelled using logistic regression with prognostic score stratification for potential confounders. Within-site ORs were pooled by random effects meta-analysis. Outcome measure: PTB (gestational age <37 weeks). Results: Absolute risk of PTB for each IPI was 3–6% after a previous term birth and 17–22% after previous PTB. ORs for PTB differed between previous term and preterm births in all countries (P-for-interaction ≤ 0.001). For women with a previous term birth, pooled ORs were increased for IPI <6 months (OR 1.50, 95% CI 1.43–1.58); 6–11 months (OR 1.10, 95% CI 1.04–1.16); 24–59 months (OR 1.16, 95% CI 1.13–1.18); and ≥ 60 months (OR 1.72, 95%CI 1.60–1.86), compared with 18–23 months. For previous PTB, ORs were increased for <6 months (OR 1.30, 95% CI 1.18–1.42) and ≥60 months (OR 1.29, 95% CI 1.17–1.42), but were less than ORs among women with a previous term birth (P < 0.05). Conclusions: Associations between IPI and PTB are modified by whether or not the previous pregnancy was preterm. ORs for short and long IPIs were higher among women with a previous term birth than a previous PTB, which for short IPI is consistent with the maternal depletion hypothesis. Given the high risk of recurrence and assuming a causal association between IPI and PTB, IPI remains a potentially modifiable risk factor for women with previous PTB. Tweetable abstract: Short versus long interpregnancy intervals associated with higher ORs for preterm birth (PTB) after a previous PTB. |
| first_indexed | 2025-11-14T11:39:41Z |
| format | Journal Article |
| id | curtin-20.500.11937-93241 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:39:41Z |
| publishDate | 2021 |
| publisher | WILEY |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-932412023-10-06T07:53:25Z Associations between interpregnancy interval and preterm birth by previous preterm birth status in four high-income countries: a cohort study Marinovich, Luke Regan, Annette Gissler, M. Magnus, M.C. Håberg, S.E. Mayo, J.A. Shaw, G.M. Bell, J. Nassar, N. Ball, Stephen Gebremedhin, Amanuel Marston, C. de Klerk, N. Betrán, A.P. Padula, A.M. Pereira, Gavin Science & Technology Life Sciences & Biomedicine Obstetrics & Gynecology Effect modification interpregnancy interval preterm birth PERINATAL HEALTH OUTCOMES INFANT RISK Effect modification interpregnancy interval preterm birth Adolescent Adult Birth Intervals California Cohort Studies Developed Countries Female Finland Humans Longitudinal Studies New South Wales Norway Odds Ratio Pregnancy Premature Birth Risk Factors Young Adult Humans Premature Birth Odds Ratio Risk Factors Cohort Studies Longitudinal Studies Pregnancy Birth Intervals Developed Countries Adolescent Adult California New South Wales Finland Norway Female Young Adult Objective: To investigate the effect of interpregnancy interval (IPI) on preterm birth (PTB) according to whether the previous birth was preterm or term. Design: Cohort study. Setting: USA (California), Australia, Finland, Norway (1980–2017). Population: Women who gave birth to first and second (n = 3 213 855) singleton livebirths. Methods: Odds ratios (ORs) for PTB according to IPIs were modelled using logistic regression with prognostic score stratification for potential confounders. Within-site ORs were pooled by random effects meta-analysis. Outcome measure: PTB (gestational age <37 weeks). Results: Absolute risk of PTB for each IPI was 3–6% after a previous term birth and 17–22% after previous PTB. ORs for PTB differed between previous term and preterm births in all countries (P-for-interaction ≤ 0.001). For women with a previous term birth, pooled ORs were increased for IPI <6 months (OR 1.50, 95% CI 1.43–1.58); 6–11 months (OR 1.10, 95% CI 1.04–1.16); 24–59 months (OR 1.16, 95% CI 1.13–1.18); and ≥ 60 months (OR 1.72, 95%CI 1.60–1.86), compared with 18–23 months. For previous PTB, ORs were increased for <6 months (OR 1.30, 95% CI 1.18–1.42) and ≥60 months (OR 1.29, 95% CI 1.17–1.42), but were less than ORs among women with a previous term birth (P < 0.05). Conclusions: Associations between IPI and PTB are modified by whether or not the previous pregnancy was preterm. ORs for short and long IPIs were higher among women with a previous term birth than a previous PTB, which for short IPI is consistent with the maternal depletion hypothesis. Given the high risk of recurrence and assuming a causal association between IPI and PTB, IPI remains a potentially modifiable risk factor for women with previous PTB. Tweetable abstract: Short versus long interpregnancy intervals associated with higher ORs for preterm birth (PTB) after a previous PTB. 2021 Journal Article http://hdl.handle.net/20.500.11937/93241 10.1111/1471-0528.16606 English http://purl.org/au-research/grants/nhmrc/1138425 http://purl.org/au-research/grants/nhmrc/1067066 http://purl.org/au-research/grants/nhmrc/1173991 http://purl.org/au-research/grants/nhmrc/1099655 WILEY fulltext |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Obstetrics & Gynecology Effect modification interpregnancy interval preterm birth PERINATAL HEALTH OUTCOMES INFANT RISK Effect modification interpregnancy interval preterm birth Adolescent Adult Birth Intervals California Cohort Studies Developed Countries Female Finland Humans Longitudinal Studies New South Wales Norway Odds Ratio Pregnancy Premature Birth Risk Factors Young Adult Humans Premature Birth Odds Ratio Risk Factors Cohort Studies Longitudinal Studies Pregnancy Birth Intervals Developed Countries Adolescent Adult California New South Wales Finland Norway Female Young Adult Marinovich, Luke Regan, Annette Gissler, M. Magnus, M.C. Håberg, S.E. Mayo, J.A. Shaw, G.M. Bell, J. Nassar, N. Ball, Stephen Gebremedhin, Amanuel Marston, C. de Klerk, N. Betrán, A.P. Padula, A.M. Pereira, Gavin Associations between interpregnancy interval and preterm birth by previous preterm birth status in four high-income countries: a cohort study |
| title | Associations between interpregnancy interval and preterm birth by previous preterm birth status in four high-income countries: a cohort study |
| title_full | Associations between interpregnancy interval and preterm birth by previous preterm birth status in four high-income countries: a cohort study |
| title_fullStr | Associations between interpregnancy interval and preterm birth by previous preterm birth status in four high-income countries: a cohort study |
| title_full_unstemmed | Associations between interpregnancy interval and preterm birth by previous preterm birth status in four high-income countries: a cohort study |
| title_short | Associations between interpregnancy interval and preterm birth by previous preterm birth status in four high-income countries: a cohort study |
| title_sort | associations between interpregnancy interval and preterm birth by previous preterm birth status in four high-income countries: a cohort study |
| topic | Science & Technology Life Sciences & Biomedicine Obstetrics & Gynecology Effect modification interpregnancy interval preterm birth PERINATAL HEALTH OUTCOMES INFANT RISK Effect modification interpregnancy interval preterm birth Adolescent Adult Birth Intervals California Cohort Studies Developed Countries Female Finland Humans Longitudinal Studies New South Wales Norway Odds Ratio Pregnancy Premature Birth Risk Factors Young Adult Humans Premature Birth Odds Ratio Risk Factors Cohort Studies Longitudinal Studies Pregnancy Birth Intervals Developed Countries Adolescent Adult California New South Wales Finland Norway Female Young Adult |
| url | http://purl.org/au-research/grants/nhmrc/1138425 http://purl.org/au-research/grants/nhmrc/1138425 http://purl.org/au-research/grants/nhmrc/1138425 http://purl.org/au-research/grants/nhmrc/1138425 http://hdl.handle.net/20.500.11937/93241 |