Associations between endometriosis and adverse pregnancy and perinatal outcomes: a population-based cohort study
Purpose: To examine the association between endometriosis and adverse pregnancy and perinatal outcomes (preeclampsia, placenta previa, and preterm birth). Methods: A population-based retrospective cohort study was conducted among 468,778 eligible women who contributed 912,747 singleton livebirths be...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Language: | English |
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2023
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| Online Access: | http://purl.org/au-research/grants/nhmrc/1099655 http://hdl.handle.net/20.500.11937/93236 |
| _version_ | 1848765715575734272 |
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| author | Gebremedhin, Amanuel Mitter, V.R. Adema, Bereket Duko Tessema, Gizachew Pereira, Gavin |
| author_facet | Gebremedhin, Amanuel Mitter, V.R. Adema, Bereket Duko Tessema, Gizachew Pereira, Gavin |
| author_sort | Gebremedhin, Amanuel |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Purpose: To examine the association between endometriosis and adverse pregnancy and perinatal outcomes (preeclampsia, placenta previa, and preterm birth). Methods: A population-based retrospective cohort study was conducted among 468,778 eligible women who contributed 912,747 singleton livebirths between 1980 and 2015 in Western Australia (WA). We used probabilistically linked perinatal and hospital separation data from the WA data linkage system’s Midwives Notification System and Hospital Morbidity Data Collection databases. We used a doubly robust estimator by combining the inverse probability weighting with the outcome regression model to estimate adjusted risk ratios (RR) and 95% confidence intervals (CIs). Results: There were 19,476 singleton livebirths among 8874 women diagnosed with endometriosis. Using a doubly robust estimator, we found pregnancies in women with endometriosis to be associated with an increased risk of preeclampsia with RR of 1.18, 95% CI 1.11–1.26, placenta previa (RR 1.59, 95% CI 1.42–1.79) and preterm birth (RR 1.45, 95% CI 1.37–1.54). The observed association persisted after stratified by the use of Medically Assisted Reproduction, with a slightly elevated risk among pregnancies conceived spontaneously. Conclusions: In this large population-based cohort, endometriosis is associated with an increased risk of preeclampsia, placenta previa, and preterm birth, independent of the use of Medically Assisted Reproduction. This may help to enhance future obstetric care among this population. |
| first_indexed | 2025-11-14T11:39:39Z |
| format | Journal Article |
| id | curtin-20.500.11937-93236 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:39:39Z |
| publishDate | 2023 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-932362023-10-10T06:39:18Z Associations between endometriosis and adverse pregnancy and perinatal outcomes: a population-based cohort study Gebremedhin, Amanuel Mitter, V.R. Adema, Bereket Duko Tessema, Gizachew Pereira, Gavin Endometriosis Medically assisted reproduction Placenta previa Preeclampsia Preterm birth Purpose: To examine the association between endometriosis and adverse pregnancy and perinatal outcomes (preeclampsia, placenta previa, and preterm birth). Methods: A population-based retrospective cohort study was conducted among 468,778 eligible women who contributed 912,747 singleton livebirths between 1980 and 2015 in Western Australia (WA). We used probabilistically linked perinatal and hospital separation data from the WA data linkage system’s Midwives Notification System and Hospital Morbidity Data Collection databases. We used a doubly robust estimator by combining the inverse probability weighting with the outcome regression model to estimate adjusted risk ratios (RR) and 95% confidence intervals (CIs). Results: There were 19,476 singleton livebirths among 8874 women diagnosed with endometriosis. Using a doubly robust estimator, we found pregnancies in women with endometriosis to be associated with an increased risk of preeclampsia with RR of 1.18, 95% CI 1.11–1.26, placenta previa (RR 1.59, 95% CI 1.42–1.79) and preterm birth (RR 1.45, 95% CI 1.37–1.54). The observed association persisted after stratified by the use of Medically Assisted Reproduction, with a slightly elevated risk among pregnancies conceived spontaneously. Conclusions: In this large population-based cohort, endometriosis is associated with an increased risk of preeclampsia, placenta previa, and preterm birth, independent of the use of Medically Assisted Reproduction. This may help to enhance future obstetric care among this population. 2023 Journal Article http://hdl.handle.net/20.500.11937/93236 10.1007/s00404-023-07002-y eng http://purl.org/au-research/grants/nhmrc/1099655 http://purl.org/au-research/grants/nhmrc/1173991 http://purl.org/au-research/grants/nhmrc/1195716 http://creativecommons.org/licenses/by/4.0/ fulltext |
| spellingShingle | Endometriosis Medically assisted reproduction Placenta previa Preeclampsia Preterm birth Gebremedhin, Amanuel Mitter, V.R. Adema, Bereket Duko Tessema, Gizachew Pereira, Gavin Associations between endometriosis and adverse pregnancy and perinatal outcomes: a population-based cohort study |
| title | Associations between endometriosis and adverse pregnancy and perinatal outcomes: a population-based cohort study |
| title_full | Associations between endometriosis and adverse pregnancy and perinatal outcomes: a population-based cohort study |
| title_fullStr | Associations between endometriosis and adverse pregnancy and perinatal outcomes: a population-based cohort study |
| title_full_unstemmed | Associations between endometriosis and adverse pregnancy and perinatal outcomes: a population-based cohort study |
| title_short | Associations between endometriosis and adverse pregnancy and perinatal outcomes: a population-based cohort study |
| title_sort | associations between endometriosis and adverse pregnancy and perinatal outcomes: a population-based cohort study |
| topic | Endometriosis Medically assisted reproduction Placenta previa Preeclampsia Preterm birth |
| url | http://purl.org/au-research/grants/nhmrc/1099655 http://purl.org/au-research/grants/nhmrc/1099655 http://purl.org/au-research/grants/nhmrc/1099655 http://hdl.handle.net/20.500.11937/93236 |