Trends and burden of diabetes in pregnancy among Aboriginal and non-Aboriginal mothers in Western Australia, 1998–2015
Background: Diabetes in pregnancy (DIP), which includes pre-gestational and gestational diabetes, is more prevalent among Aboriginal women. DIP and its adverse neonatal outcomes are associated with diabetes and cardiovascular disease in the offspring. This study investigated the impact of DIP on tre...
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| Format: | Journal Article |
| Language: | English |
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BMC
2022
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| Online Access: | http://purl.org/au-research/grants/nhmrc/1127265 http://hdl.handle.net/20.500.11937/93234 |
| _version_ | 1848765715016843264 |
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| author | Ahmed, M.A. Bailey, Helen Pereira, Gavin White, S.W. Wong, Kingsley Shepherd, Carrington |
| author_facet | Ahmed, M.A. Bailey, Helen Pereira, Gavin White, S.W. Wong, Kingsley Shepherd, Carrington |
| author_sort | Ahmed, M.A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Diabetes in pregnancy (DIP), which includes pre-gestational and gestational diabetes, is more prevalent among Aboriginal women. DIP and its adverse neonatal outcomes are associated with diabetes and cardiovascular disease in the offspring. This study investigated the impact of DIP on trends of large for gestational age (LGA) in Aboriginal and non-Aboriginal populations, and added to the limited evidence on temporal trends of DIP burden in these populations. Methods: We conducted a retrospective cohort study that included all births in Western Australia between 1998 and 2015 using linked population health datasets. Time trends of age-standardised and crude rates of pre-gestational and gestational diabetes were estimated in Aboriginal and non-Aboriginal mothers. Mixed-effects multivariable logistic regression was used to estimate the association between DIP and population LGA trends over time. Results: Over the study period, there were 526,319 births in Western Australia, of which 6.4% were to Aboriginal mothers. The age-standardised annual rates of pre-gestational diabetes among Aboriginal mothers rose from 4.3% in 1998 to 5.4% in 2015 and remained below 1% in non-Aboriginal women. The comparable rates for gestational diabetes increased from 6.7 to 11.5% over the study period in Aboriginal women, and from 3.5 to 10.2% among non-Aboriginal mothers. LGA rates in Aboriginal babies remained high with inconsistent and no improvement in pregnancies complicated by gestational diabetes and pre-gestational diabetes, respectively. Regression analyses showed that DIP explained a large part of the increasing LGA rates over time in Aboriginal babies. Conclusions: There has been a substantial increase in the burden of pre-gestational diabetes (Aboriginal women) and gestational diabetes (Aboriginal and non-Aboriginal) in recent decades. DIP appears to substantially contribute to increasing trends in LGA among Aboriginal babies. |
| first_indexed | 2025-11-14T11:39:39Z |
| format | Journal Article |
| id | curtin-20.500.11937-93234 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:39:39Z |
| publishDate | 2022 |
| publisher | BMC |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-932342024-04-19T08:43:58Z Trends and burden of diabetes in pregnancy among Aboriginal and non-Aboriginal mothers in Western Australia, 1998–2015 Ahmed, M.A. Bailey, Helen Pereira, Gavin White, S.W. Wong, Kingsley Shepherd, Carrington Science & Technology Life Sciences & Biomedicine Public, Environmental & Occupational Health Aboriginal Torres Strait Islanders Indigenous Diabetes in pregnancy Pre-gestational diabetes Gestational diabetes Large for gestational age NON-INDIGENOUS CHILDREN 1ST NATIONS BIRTH-WEIGHT PREVALENCE MELLITUS WOMEN RISK IMPACT ASSOCIATION EXPOSURE Aboriginal Diabetes in pregnancy Gestational diabetes Indigenous Large for gestational age Pre-gestational diabetes Torres Strait Islanders Diabetes, Gestational Female Humans Infant, Newborn Mothers Pregnancy Retrospective Studies Western Australia Humans Diabetes, Gestational Retrospective Studies Mothers Pregnancy Infant, Newborn Western Australia Female Background: Diabetes in pregnancy (DIP), which includes pre-gestational and gestational diabetes, is more prevalent among Aboriginal women. DIP and its adverse neonatal outcomes are associated with diabetes and cardiovascular disease in the offspring. This study investigated the impact of DIP on trends of large for gestational age (LGA) in Aboriginal and non-Aboriginal populations, and added to the limited evidence on temporal trends of DIP burden in these populations. Methods: We conducted a retrospective cohort study that included all births in Western Australia between 1998 and 2015 using linked population health datasets. Time trends of age-standardised and crude rates of pre-gestational and gestational diabetes were estimated in Aboriginal and non-Aboriginal mothers. Mixed-effects multivariable logistic regression was used to estimate the association between DIP and population LGA trends over time. Results: Over the study period, there were 526,319 births in Western Australia, of which 6.4% were to Aboriginal mothers. The age-standardised annual rates of pre-gestational diabetes among Aboriginal mothers rose from 4.3% in 1998 to 5.4% in 2015 and remained below 1% in non-Aboriginal women. The comparable rates for gestational diabetes increased from 6.7 to 11.5% over the study period in Aboriginal women, and from 3.5 to 10.2% among non-Aboriginal mothers. LGA rates in Aboriginal babies remained high with inconsistent and no improvement in pregnancies complicated by gestational diabetes and pre-gestational diabetes, respectively. Regression analyses showed that DIP explained a large part of the increasing LGA rates over time in Aboriginal babies. Conclusions: There has been a substantial increase in the burden of pre-gestational diabetes (Aboriginal women) and gestational diabetes (Aboriginal and non-Aboriginal) in recent decades. DIP appears to substantially contribute to increasing trends in LGA among Aboriginal babies. 2022 Journal Article http://hdl.handle.net/20.500.11937/93234 10.1186/s12889-022-12663-6 English http://purl.org/au-research/grants/nhmrc/1127265 http://purl.org/au-research/grants/nhmrc/1099655 http://purl.org/au-research/grants/nhmrc/1173991 http://creativecommons.org/licenses/by/4.0/ BMC fulltext |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Public, Environmental & Occupational Health Aboriginal Torres Strait Islanders Indigenous Diabetes in pregnancy Pre-gestational diabetes Gestational diabetes Large for gestational age NON-INDIGENOUS CHILDREN 1ST NATIONS BIRTH-WEIGHT PREVALENCE MELLITUS WOMEN RISK IMPACT ASSOCIATION EXPOSURE Aboriginal Diabetes in pregnancy Gestational diabetes Indigenous Large for gestational age Pre-gestational diabetes Torres Strait Islanders Diabetes, Gestational Female Humans Infant, Newborn Mothers Pregnancy Retrospective Studies Western Australia Humans Diabetes, Gestational Retrospective Studies Mothers Pregnancy Infant, Newborn Western Australia Female Ahmed, M.A. Bailey, Helen Pereira, Gavin White, S.W. Wong, Kingsley Shepherd, Carrington Trends and burden of diabetes in pregnancy among Aboriginal and non-Aboriginal mothers in Western Australia, 1998–2015 |
| title | Trends and burden of diabetes in pregnancy among Aboriginal and non-Aboriginal mothers in Western Australia, 1998–2015 |
| title_full | Trends and burden of diabetes in pregnancy among Aboriginal and non-Aboriginal mothers in Western Australia, 1998–2015 |
| title_fullStr | Trends and burden of diabetes in pregnancy among Aboriginal and non-Aboriginal mothers in Western Australia, 1998–2015 |
| title_full_unstemmed | Trends and burden of diabetes in pregnancy among Aboriginal and non-Aboriginal mothers in Western Australia, 1998–2015 |
| title_short | Trends and burden of diabetes in pregnancy among Aboriginal and non-Aboriginal mothers in Western Australia, 1998–2015 |
| title_sort | trends and burden of diabetes in pregnancy among aboriginal and non-aboriginal mothers in western australia, 1998–2015 |
| topic | Science & Technology Life Sciences & Biomedicine Public, Environmental & Occupational Health Aboriginal Torres Strait Islanders Indigenous Diabetes in pregnancy Pre-gestational diabetes Gestational diabetes Large for gestational age NON-INDIGENOUS CHILDREN 1ST NATIONS BIRTH-WEIGHT PREVALENCE MELLITUS WOMEN RISK IMPACT ASSOCIATION EXPOSURE Aboriginal Diabetes in pregnancy Gestational diabetes Indigenous Large for gestational age Pre-gestational diabetes Torres Strait Islanders Diabetes, Gestational Female Humans Infant, Newborn Mothers Pregnancy Retrospective Studies Western Australia Humans Diabetes, Gestational Retrospective Studies Mothers Pregnancy Infant, Newborn Western Australia Female |
| url | http://purl.org/au-research/grants/nhmrc/1127265 http://purl.org/au-research/grants/nhmrc/1127265 http://purl.org/au-research/grants/nhmrc/1127265 http://hdl.handle.net/20.500.11937/93234 |