The role of intervening pregnancy loss in the association between interpregnancy interval and adverse pregnancy outcomes
Objective: To investigate whether intervening miscarriages and induced abortions impact the associations between interpregnancy interval after a live birth and adverse pregnancy outcomes. Design: Population-based cohort study. Setting: Norway. Participants: A total of 165 617 births to 143 916 women...
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| Format: | Journal Article |
| Language: | English |
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WILEY
2022
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| Online Access: | http://purl.org/au-research/grants/nhmrc/1099655 http://hdl.handle.net/20.500.11937/93231 |
| _version_ | 1848765714111922176 |
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| author | Tessema, Gizachew Håberg, S.E. Pereira, Gavin Magnus, M.C. |
| author_facet | Tessema, Gizachew Håberg, S.E. Pereira, Gavin Magnus, M.C. |
| author_sort | Tessema, Gizachew |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objective: To investigate whether intervening miscarriages and induced abortions impact the associations between interpregnancy interval after a live birth and adverse pregnancy outcomes. Design: Population-based cohort study. Setting: Norway. Participants: A total of 165 617 births to 143 916 women between 2008 and 2016. Main outcome measures: We estimated adjusted relative risks for adverse pregnancy outcomes using log-binomial regression, first ignoring miscarriages and induced abortions in the interpregnancy interval estimation (conventional interpregnancy interval estimates) and subsequently accounting for intervening miscarriages or induced abortions (correct interpregnancy interval estimates). We then calculated the ratio of the two relative risks (ratio of ratios, RoR) as a measure of the difference. Results: The proportion of short interpregnancy interval (<6 months) was 4.0% in the conventional interpregnancy interval estimate and slightly increased to 4.6% in the correct interpregnancy interval estimate. For interpregnancy interval <6 months, compared with 18–23 months, the RoR was 0.97 for preterm birth (PTB) (95% confidence interval [CI] 0.83–1.13), 0.97 for spontaneous PTB (95% CI 0.80–1.19), 1.00 for small-for-gestational age (95% CI 0.86–1.14), 1.00 for large-for-gestational age (95% CI 0.90–1.10) and 0.99 for pre-eclampsia (95% CI 0.71–1.37). Similarly, conventional and correct interpregnancy intervals yielded associations of similar magnitude between long interpregnancy interval (≥60 months) and the pregnancy outcomes evaluated. Conclusion: Not considering intervening pregnancy loss due to miscarriages or induced abortions, results in negligible difference in the associations between short and long interpregnancy intervals and adverse pregnancy outcomes. Tweetable abstract: Not considering pregnancy loss in interpregnancy interval estimation resulted no meaningful differences in observed risks of adverse pregnancy outcomes. |
| first_indexed | 2025-11-14T11:39:38Z |
| format | Journal Article |
| id | curtin-20.500.11937-93231 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:39:38Z |
| publishDate | 2022 |
| publisher | WILEY |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-932312023-10-09T07:39:04Z The role of intervening pregnancy loss in the association between interpregnancy interval and adverse pregnancy outcomes Tessema, Gizachew Håberg, S.E. Pereira, Gavin Magnus, M.C. Science & Technology Life Sciences & Biomedicine Obstetrics & Gynecology induced abortions interpregnancy interval large-for-gestational age miscarriages pre-eclampsia preterm birth small-for-gestational age PERINATAL OUTCOMES SUBSEQUENT RISK PRETERM BIRTH ABORTION REGISTRY HEALTH IMPACT induced abortions interpregnancy interval large-for-gestational age miscarriages pre-eclampsia preterm birth small-for-gestational age Abortion, Induced Abortion, Spontaneous Birth Intervals Cohort Studies Female Humans Infant, Newborn Pregnancy Pregnancy Outcome Premature Birth Humans Abortion, Spontaneous Premature Birth Pregnancy Outcome Abortion, Induced Cohort Studies Pregnancy Birth Intervals Infant, Newborn Female Objective: To investigate whether intervening miscarriages and induced abortions impact the associations between interpregnancy interval after a live birth and adverse pregnancy outcomes. Design: Population-based cohort study. Setting: Norway. Participants: A total of 165 617 births to 143 916 women between 2008 and 2016. Main outcome measures: We estimated adjusted relative risks for adverse pregnancy outcomes using log-binomial regression, first ignoring miscarriages and induced abortions in the interpregnancy interval estimation (conventional interpregnancy interval estimates) and subsequently accounting for intervening miscarriages or induced abortions (correct interpregnancy interval estimates). We then calculated the ratio of the two relative risks (ratio of ratios, RoR) as a measure of the difference. Results: The proportion of short interpregnancy interval (<6 months) was 4.0% in the conventional interpregnancy interval estimate and slightly increased to 4.6% in the correct interpregnancy interval estimate. For interpregnancy interval <6 months, compared with 18–23 months, the RoR was 0.97 for preterm birth (PTB) (95% confidence interval [CI] 0.83–1.13), 0.97 for spontaneous PTB (95% CI 0.80–1.19), 1.00 for small-for-gestational age (95% CI 0.86–1.14), 1.00 for large-for-gestational age (95% CI 0.90–1.10) and 0.99 for pre-eclampsia (95% CI 0.71–1.37). Similarly, conventional and correct interpregnancy intervals yielded associations of similar magnitude between long interpregnancy interval (≥60 months) and the pregnancy outcomes evaluated. Conclusion: Not considering intervening pregnancy loss due to miscarriages or induced abortions, results in negligible difference in the associations between short and long interpregnancy intervals and adverse pregnancy outcomes. Tweetable abstract: Not considering pregnancy loss in interpregnancy interval estimation resulted no meaningful differences in observed risks of adverse pregnancy outcomes. 2022 Journal Article http://hdl.handle.net/20.500.11937/93231 10.1111/1471-0528.17223 English http://purl.org/au-research/grants/nhmrc/1099655 http://purl.org/au-research/grants/nhmrc/1173991 http://creativecommons.org/licenses/by-nc/4.0/ WILEY fulltext |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Obstetrics & Gynecology induced abortions interpregnancy interval large-for-gestational age miscarriages pre-eclampsia preterm birth small-for-gestational age PERINATAL OUTCOMES SUBSEQUENT RISK PRETERM BIRTH ABORTION REGISTRY HEALTH IMPACT induced abortions interpregnancy interval large-for-gestational age miscarriages pre-eclampsia preterm birth small-for-gestational age Abortion, Induced Abortion, Spontaneous Birth Intervals Cohort Studies Female Humans Infant, Newborn Pregnancy Pregnancy Outcome Premature Birth Humans Abortion, Spontaneous Premature Birth Pregnancy Outcome Abortion, Induced Cohort Studies Pregnancy Birth Intervals Infant, Newborn Female Tessema, Gizachew Håberg, S.E. Pereira, Gavin Magnus, M.C. The role of intervening pregnancy loss in the association between interpregnancy interval and adverse pregnancy outcomes |
| title | The role of intervening pregnancy loss in the association between interpregnancy interval and adverse pregnancy outcomes |
| title_full | The role of intervening pregnancy loss in the association between interpregnancy interval and adverse pregnancy outcomes |
| title_fullStr | The role of intervening pregnancy loss in the association between interpregnancy interval and adverse pregnancy outcomes |
| title_full_unstemmed | The role of intervening pregnancy loss in the association between interpregnancy interval and adverse pregnancy outcomes |
| title_short | The role of intervening pregnancy loss in the association between interpregnancy interval and adverse pregnancy outcomes |
| title_sort | role of intervening pregnancy loss in the association between interpregnancy interval and adverse pregnancy outcomes |
| topic | Science & Technology Life Sciences & Biomedicine Obstetrics & Gynecology induced abortions interpregnancy interval large-for-gestational age miscarriages pre-eclampsia preterm birth small-for-gestational age PERINATAL OUTCOMES SUBSEQUENT RISK PRETERM BIRTH ABORTION REGISTRY HEALTH IMPACT induced abortions interpregnancy interval large-for-gestational age miscarriages pre-eclampsia preterm birth small-for-gestational age Abortion, Induced Abortion, Spontaneous Birth Intervals Cohort Studies Female Humans Infant, Newborn Pregnancy Pregnancy Outcome Premature Birth Humans Abortion, Spontaneous Premature Birth Pregnancy Outcome Abortion, Induced Cohort Studies Pregnancy Birth Intervals Infant, Newborn Female |
| url | http://purl.org/au-research/grants/nhmrc/1099655 http://purl.org/au-research/grants/nhmrc/1099655 http://hdl.handle.net/20.500.11937/93231 |