Comparison of Performance of Micro-Computed Tomography (Micro-CT) and Synchrotron Radiation CT in Assessing Coronary Stenosis Caused by Calcified Plaques in Coronary Artery Phantoms
Synchrotron-radiation-computed tomography (SRCT) allows more accurate calcified plaque and coronary stenosis assessment as a result of its superior spatial resolution; however, typical micro-computed tomography (micro-CT) systems have even higher resolution. The purpose of this study was to compare...
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| Format: | Journal Article |
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MDPI
2023
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| Online Access: | This research was funded by Curtin Medical School Seed Grants 2022, Curtin University, Australia http://hdl.handle.net/20.500.11937/93121 |
| _version_ | 1848765703750942720 |
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| author | Ng, Curtise Sun, Zhonghua Jansen, Shirley |
| author_facet | Ng, Curtise Sun, Zhonghua Jansen, Shirley |
| author_sort | Ng, Curtise |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Synchrotron-radiation-computed tomography (SRCT) allows more accurate calcified plaque and coronary stenosis assessment as a result of its superior spatial resolution; however, typical micro-computed tomography (micro-CT) systems have even higher resolution. The purpose of this study was to compare the performance of high-resolution micro-CT with SRCT in the assessment of calcified plaques and a previously published dataset of coronary stenosis assessment. This experimental study involved micro-CT scanning of three-dimensional printed coronary artery models with calcification in situ used in our previously published SRCT study on coronary stenosis assessment. Measurements of coronary stenosis utilizing both modalities were compared using a paired sample t-test. The degrees of stenosis measured on all but one micro-CT dataset were statistically significantly lower than the corresponding SRCT measurements reported in our previous paper (p < 0.0005–0.05). This indicates that the superior spatial resolution of micro-CT was able to further reduce over-estimation of stenosis caused by extensive calcification of coronary arteries and, hence, false positive results. Our results showed that the high-resolution micro-CT used in this study outperformed the Australian Synchrotron SRCT in both calcified plaque and coronary stenosis assessment. These findings will become clinically important for cardiovascular event prediction and enable reclassification of individuals with low and intermediate risk into appropriate risk categories when the technical challenges of micro-CT in clinical practice such as the small field of view and demanding on image processing power are addressed. |
| first_indexed | 2025-11-14T11:39:28Z |
| format | Journal Article |
| id | curtin-20.500.11937-93121 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:39:28Z |
| publishDate | 2023 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-931212023-10-02T00:51:20Z Comparison of Performance of Micro-Computed Tomography (Micro-CT) and Synchrotron Radiation CT in Assessing Coronary Stenosis Caused by Calcified Plaques in Coronary Artery Phantoms Ng, Curtise Sun, Zhonghua Jansen, Shirley 3D printing accuracy calcification cardiovascular disease computed tomography coronary artery disease coronary stenosis micro-computed tomography plaque synchrotron radiation Synchrotron-radiation-computed tomography (SRCT) allows more accurate calcified plaque and coronary stenosis assessment as a result of its superior spatial resolution; however, typical micro-computed tomography (micro-CT) systems have even higher resolution. The purpose of this study was to compare the performance of high-resolution micro-CT with SRCT in the assessment of calcified plaques and a previously published dataset of coronary stenosis assessment. This experimental study involved micro-CT scanning of three-dimensional printed coronary artery models with calcification in situ used in our previously published SRCT study on coronary stenosis assessment. Measurements of coronary stenosis utilizing both modalities were compared using a paired sample t-test. The degrees of stenosis measured on all but one micro-CT dataset were statistically significantly lower than the corresponding SRCT measurements reported in our previous paper (p < 0.0005–0.05). This indicates that the superior spatial resolution of micro-CT was able to further reduce over-estimation of stenosis caused by extensive calcification of coronary arteries and, hence, false positive results. Our results showed that the high-resolution micro-CT used in this study outperformed the Australian Synchrotron SRCT in both calcified plaque and coronary stenosis assessment. These findings will become clinically important for cardiovascular event prediction and enable reclassification of individuals with low and intermediate risk into appropriate risk categories when the technical challenges of micro-CT in clinical practice such as the small field of view and demanding on image processing power are addressed. 2023 Journal Article http://hdl.handle.net/20.500.11937/93121 10.3390/jvd2030026 This research was funded by Curtin Medical School Seed Grants 2022, Curtin University, Australia https://creativecommons.org/licenses/by/4.0/ MDPI fulltext |
| spellingShingle | 3D printing accuracy calcification cardiovascular disease computed tomography coronary artery disease coronary stenosis micro-computed tomography plaque synchrotron radiation Ng, Curtise Sun, Zhonghua Jansen, Shirley Comparison of Performance of Micro-Computed Tomography (Micro-CT) and Synchrotron Radiation CT in Assessing Coronary Stenosis Caused by Calcified Plaques in Coronary Artery Phantoms |
| title | Comparison of Performance of Micro-Computed Tomography (Micro-CT) and Synchrotron Radiation CT in Assessing Coronary Stenosis Caused by Calcified Plaques in Coronary Artery Phantoms |
| title_full | Comparison of Performance of Micro-Computed Tomography (Micro-CT) and Synchrotron Radiation CT in Assessing Coronary Stenosis Caused by Calcified Plaques in Coronary Artery Phantoms |
| title_fullStr | Comparison of Performance of Micro-Computed Tomography (Micro-CT) and Synchrotron Radiation CT in Assessing Coronary Stenosis Caused by Calcified Plaques in Coronary Artery Phantoms |
| title_full_unstemmed | Comparison of Performance of Micro-Computed Tomography (Micro-CT) and Synchrotron Radiation CT in Assessing Coronary Stenosis Caused by Calcified Plaques in Coronary Artery Phantoms |
| title_short | Comparison of Performance of Micro-Computed Tomography (Micro-CT) and Synchrotron Radiation CT in Assessing Coronary Stenosis Caused by Calcified Plaques in Coronary Artery Phantoms |
| title_sort | comparison of performance of micro-computed tomography (micro-ct) and synchrotron radiation ct in assessing coronary stenosis caused by calcified plaques in coronary artery phantoms |
| topic | 3D printing accuracy calcification cardiovascular disease computed tomography coronary artery disease coronary stenosis micro-computed tomography plaque synchrotron radiation |
| url | This research was funded by Curtin Medical School Seed Grants 2022, Curtin University, Australia http://hdl.handle.net/20.500.11937/93121 |