Outcomes in patients with peripheral vascular disease following percutaneous coronary intervention
Objectives: To evaluate the clinical characteristics and outcomes of patients with peripheral vascular disease (PVD) undergoing percutaneous coronary intervention (PCI) in a contemporary setting, and to determine whether use of drug-eluting stents (DESs) improves outcomes. Background: PVD was an ind...
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| Format: | Journal Article |
| Language: | English |
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WILEY
2019
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| Online Access: | http://purl.org/au-research/grants/nhmrc/1111170 http://hdl.handle.net/20.500.11937/93107 |
| _version_ | 1848765699762159616 |
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| author | Ramzy, J. Andrianopoulos, N. Roberts, L. Duffy, S.J. Clark, D. Teh, A.W. Ajani, A.E. Reid, Christopher Brennan, A. Freeman, M. |
| author_facet | Ramzy, J. Andrianopoulos, N. Roberts, L. Duffy, S.J. Clark, D. Teh, A.W. Ajani, A.E. Reid, Christopher Brennan, A. Freeman, M. |
| author_sort | Ramzy, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objectives: To evaluate the clinical characteristics and outcomes of patients with peripheral vascular disease (PVD) undergoing percutaneous coronary intervention (PCI) in a contemporary setting, and to determine whether use of drug-eluting stents (DESs) improves outcomes. Background: PVD was an independent risk factor for adverse outcomes following PCI in the bare-metal stent (BMS) era. It is not known whether outcomes in these patients have improved with advances in interventional techniques and stent technology, as they have for the general population. Methods: Eighteen thousand three hundred and eighty patients undergoing PCI from an Australian registry between 2005 and 2013 were studied. Clinical and procedural data, 30-day and 12-month outcomes were compared in those with and without a reported history of PVD. Outcomes were also compared between patients with PVD who received DES and those who received BMS. Long-term mortality was compared using Australian National Death Index (NDI) linkage. Results: Patients with PVD (n = 1,251, 6.8%) were older and had more prevalent diabetes, hypertension, cerebrovascular disease, heart failure, renal impairment, ostial lesions, left main, and multi-vessel disease (p < 0.001). Patients with PVD had significantly higher rates of major adverse cardiovascular events (MACEs) compared with those without PVD, in-hospital (5.7% vs. 4.1%, p < 0.008), at 30-days (8.6% vs. 5.8%, p < 0.001) and at 12-months (24.6% vs. 13.2%, p < 0.001). At 4.9 ± 2.6 years follow-up, there was significantly greater mortality in the PVD group. PVD patients who received DES experienced significantly less MACE than PVD patients treated with BMS at 30-days (4.8 vs. 10.1%, p < 0.001) and 12-months (19.4 vs. 26.4%, p < 0.005). Conclusions: PVD is an independent predictor of adverse outcomes in patients undergoing PCI. PVD patient who received DES had improved outcomes compared with those receiving BMS. |
| first_indexed | 2025-11-14T11:39:24Z |
| format | Journal Article |
| id | curtin-20.500.11937-93107 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:39:24Z |
| publishDate | 2019 |
| publisher | WILEY |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-931072023-09-06T01:25:18Z Outcomes in patients with peripheral vascular disease following percutaneous coronary intervention Ramzy, J. Andrianopoulos, N. Roberts, L. Duffy, S.J. Clark, D. Teh, A.W. Ajani, A.E. Reid, Christopher Brennan, A. Freeman, M. Science & Technology Life Sciences & Biomedicine Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology coronary artery disease peripheral arterial disease revascularization DRUG-ELUTING STENTS LONG-TERM OUTCOMES ACUTE MYOCARDIAL-INFARCTION ARTERIAL-DISEASE CLINICAL-OUTCOMES TASK-FORCE MORTALITY IMPACT ASSOCIATION PREDICTORS coronary artery disease peripheral arterial disease revascularization Aged Aged, 80 and over Comorbidity Coronary Artery Disease Drug-Eluting Stents Female Humans Male Metals Middle Aged Percutaneous Coronary Intervention Peripheral Vascular Diseases Prosthesis Design Registries Retrospective Studies Risk Assessment Risk Factors Stents Time Factors Treatment Outcome Victoria Melbourne Interventional Group (MIG) Humans Peripheral Vascular Diseases Metals Treatment Outcome Registries Risk Assessment Risk Factors Retrospective Studies Prosthesis Design Stents Comorbidity Time Factors Aged Aged, 80 and over Middle Aged Victoria Female Male Coronary Artery Disease Drug-Eluting Stents Percutaneous Coronary Intervention Objectives: To evaluate the clinical characteristics and outcomes of patients with peripheral vascular disease (PVD) undergoing percutaneous coronary intervention (PCI) in a contemporary setting, and to determine whether use of drug-eluting stents (DESs) improves outcomes. Background: PVD was an independent risk factor for adverse outcomes following PCI in the bare-metal stent (BMS) era. It is not known whether outcomes in these patients have improved with advances in interventional techniques and stent technology, as they have for the general population. Methods: Eighteen thousand three hundred and eighty patients undergoing PCI from an Australian registry between 2005 and 2013 were studied. Clinical and procedural data, 30-day and 12-month outcomes were compared in those with and without a reported history of PVD. Outcomes were also compared between patients with PVD who received DES and those who received BMS. Long-term mortality was compared using Australian National Death Index (NDI) linkage. Results: Patients with PVD (n = 1,251, 6.8%) were older and had more prevalent diabetes, hypertension, cerebrovascular disease, heart failure, renal impairment, ostial lesions, left main, and multi-vessel disease (p < 0.001). Patients with PVD had significantly higher rates of major adverse cardiovascular events (MACEs) compared with those without PVD, in-hospital (5.7% vs. 4.1%, p < 0.008), at 30-days (8.6% vs. 5.8%, p < 0.001) and at 12-months (24.6% vs. 13.2%, p < 0.001). At 4.9 ± 2.6 years follow-up, there was significantly greater mortality in the PVD group. PVD patients who received DES experienced significantly less MACE than PVD patients treated with BMS at 30-days (4.8 vs. 10.1%, p < 0.001) and 12-months (19.4 vs. 26.4%, p < 0.005). Conclusions: PVD is an independent predictor of adverse outcomes in patients undergoing PCI. PVD patient who received DES had improved outcomes compared with those receiving BMS. 2019 Journal Article http://hdl.handle.net/20.500.11937/93107 10.1002/ccd.28145 English http://purl.org/au-research/grants/nhmrc/1111170 WILEY fulltext |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology coronary artery disease peripheral arterial disease revascularization DRUG-ELUTING STENTS LONG-TERM OUTCOMES ACUTE MYOCARDIAL-INFARCTION ARTERIAL-DISEASE CLINICAL-OUTCOMES TASK-FORCE MORTALITY IMPACT ASSOCIATION PREDICTORS coronary artery disease peripheral arterial disease revascularization Aged Aged, 80 and over Comorbidity Coronary Artery Disease Drug-Eluting Stents Female Humans Male Metals Middle Aged Percutaneous Coronary Intervention Peripheral Vascular Diseases Prosthesis Design Registries Retrospective Studies Risk Assessment Risk Factors Stents Time Factors Treatment Outcome Victoria Melbourne Interventional Group (MIG) Humans Peripheral Vascular Diseases Metals Treatment Outcome Registries Risk Assessment Risk Factors Retrospective Studies Prosthesis Design Stents Comorbidity Time Factors Aged Aged, 80 and over Middle Aged Victoria Female Male Coronary Artery Disease Drug-Eluting Stents Percutaneous Coronary Intervention Ramzy, J. Andrianopoulos, N. Roberts, L. Duffy, S.J. Clark, D. Teh, A.W. Ajani, A.E. Reid, Christopher Brennan, A. Freeman, M. Outcomes in patients with peripheral vascular disease following percutaneous coronary intervention |
| title | Outcomes in patients with peripheral vascular disease following percutaneous coronary intervention |
| title_full | Outcomes in patients with peripheral vascular disease following percutaneous coronary intervention |
| title_fullStr | Outcomes in patients with peripheral vascular disease following percutaneous coronary intervention |
| title_full_unstemmed | Outcomes in patients with peripheral vascular disease following percutaneous coronary intervention |
| title_short | Outcomes in patients with peripheral vascular disease following percutaneous coronary intervention |
| title_sort | outcomes in patients with peripheral vascular disease following percutaneous coronary intervention |
| topic | Science & Technology Life Sciences & Biomedicine Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology coronary artery disease peripheral arterial disease revascularization DRUG-ELUTING STENTS LONG-TERM OUTCOMES ACUTE MYOCARDIAL-INFARCTION ARTERIAL-DISEASE CLINICAL-OUTCOMES TASK-FORCE MORTALITY IMPACT ASSOCIATION PREDICTORS coronary artery disease peripheral arterial disease revascularization Aged Aged, 80 and over Comorbidity Coronary Artery Disease Drug-Eluting Stents Female Humans Male Metals Middle Aged Percutaneous Coronary Intervention Peripheral Vascular Diseases Prosthesis Design Registries Retrospective Studies Risk Assessment Risk Factors Stents Time Factors Treatment Outcome Victoria Melbourne Interventional Group (MIG) Humans Peripheral Vascular Diseases Metals Treatment Outcome Registries Risk Assessment Risk Factors Retrospective Studies Prosthesis Design Stents Comorbidity Time Factors Aged Aged, 80 and over Middle Aged Victoria Female Male Coronary Artery Disease Drug-Eluting Stents Percutaneous Coronary Intervention |
| url | http://purl.org/au-research/grants/nhmrc/1111170 http://hdl.handle.net/20.500.11937/93107 |