Associations of body size with all-cause and cause-specific mortality in healthy older adults
In the general population, body mass index (BMI) and waist circumference are recognized risk factors for several chronic diseases and all-cause mortality. However, whether these associations are the same for older adults is less clear. The association of baseline BMI and waist circumference with all...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2023
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| Online Access: | http://purl.org/au-research/grants/nhmrc/334047 http://hdl.handle.net/20.500.11937/93105 |
| _version_ | 1848765699222142976 |
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| author | Carr, P.R. Webb, K.L. Neumann, J.T. Thao, L.T.P. Beilin, L.J. Ernst, M.E. Fitzgibbon, B. Gasevic, D. Nelson, M.R. Newman, A.B. Orchard, S.G. Owen, A. Reid, Christopher Stocks, N.P. Tonkin, A.M. Woods, R.L. McNeil, J.J. |
| author_facet | Carr, P.R. Webb, K.L. Neumann, J.T. Thao, L.T.P. Beilin, L.J. Ernst, M.E. Fitzgibbon, B. Gasevic, D. Nelson, M.R. Newman, A.B. Orchard, S.G. Owen, A. Reid, Christopher Stocks, N.P. Tonkin, A.M. Woods, R.L. McNeil, J.J. |
| author_sort | Carr, P.R. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | In the general population, body mass index (BMI) and waist circumference are recognized risk factors for several chronic diseases and all-cause mortality. However, whether these associations are the same for older adults is less clear. The association of baseline BMI and waist circumference with all-cause and cause-specific mortality was investigated in 18,209 Australian and US participants (mean age: 75.1 ± 4.5 years) from the ASPirin in Reducing Events in the Elderly (ASPREE) study, followed up for a median of 6.9 years (IQR: 5.7, 8.0). There were substantially different relationships observed in men and women. In men, the lowest risk of all-cause and cardiovascular mortality was observed with a BMI in the range 25.0–29.9 kg/m2 [HR25-29.9 vs 21–24.9 kg/m2: 0.85; 95% CI, 0.73–1.00] while the highest risk was in those who were underweight [HRBMI <21 kg/m2 vs BMI 21–24.9 kg/m2: 1.82; 95% CI 1.30–2.55], leading to a clear U-shaped relationship. In women, all-cause mortality was highest in those with the lowest BMI leading to a J-shaped relationship (HRBMI <21 kg/m2 vs BMI 21–24.9 kg/m2: 1.64; 95% CI 1.26–2.14). Waist circumference showed a weaker relationship with all-cause mortality in both men and women. There was little evidence of a relationship between either index of body size and subsequent cancer mortality in men or women, while non-cardiovascular non-cancer mortality was higher in underweight participants. For older men, being overweight was found to be associated with a lower risk of all-cause mortality, while among both men and women, a BMI in the underweight category was associated with a higher risk. Waist circumference alone had little association with all-cause or cause-specific mortality risk. Trial registration ASPREE https://ClinicalTrials.gov number NCT01038583. |
| first_indexed | 2025-11-14T11:39:24Z |
| format | Journal Article |
| id | curtin-20.500.11937-93105 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:39:24Z |
| publishDate | 2023 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-931052023-09-19T01:10:06Z Associations of body size with all-cause and cause-specific mortality in healthy older adults Carr, P.R. Webb, K.L. Neumann, J.T. Thao, L.T.P. Beilin, L.J. Ernst, M.E. Fitzgibbon, B. Gasevic, D. Nelson, M.R. Newman, A.B. Orchard, S.G. Owen, A. Reid, Christopher Stocks, N.P. Tonkin, A.M. Woods, R.L. McNeil, J.J. Aged Female Humans Male Aspirin Australia Body Size Cause of Death Thinness Waist Circumference Humans Thinness Aspirin Body Size Cause of Death Aged Australia Female Male Waist Circumference In the general population, body mass index (BMI) and waist circumference are recognized risk factors for several chronic diseases and all-cause mortality. However, whether these associations are the same for older adults is less clear. The association of baseline BMI and waist circumference with all-cause and cause-specific mortality was investigated in 18,209 Australian and US participants (mean age: 75.1 ± 4.5 years) from the ASPirin in Reducing Events in the Elderly (ASPREE) study, followed up for a median of 6.9 years (IQR: 5.7, 8.0). There were substantially different relationships observed in men and women. In men, the lowest risk of all-cause and cardiovascular mortality was observed with a BMI in the range 25.0–29.9 kg/m2 [HR25-29.9 vs 21–24.9 kg/m2: 0.85; 95% CI, 0.73–1.00] while the highest risk was in those who were underweight [HRBMI <21 kg/m2 vs BMI 21–24.9 kg/m2: 1.82; 95% CI 1.30–2.55], leading to a clear U-shaped relationship. In women, all-cause mortality was highest in those with the lowest BMI leading to a J-shaped relationship (HRBMI <21 kg/m2 vs BMI 21–24.9 kg/m2: 1.64; 95% CI 1.26–2.14). Waist circumference showed a weaker relationship with all-cause mortality in both men and women. There was little evidence of a relationship between either index of body size and subsequent cancer mortality in men or women, while non-cardiovascular non-cancer mortality was higher in underweight participants. For older men, being overweight was found to be associated with a lower risk of all-cause mortality, while among both men and women, a BMI in the underweight category was associated with a higher risk. Waist circumference alone had little association with all-cause or cause-specific mortality risk. Trial registration ASPREE https://ClinicalTrials.gov number NCT01038583. 2023 Journal Article http://hdl.handle.net/20.500.11937/93105 10.1038/s41598-023-29586-w eng http://purl.org/au-research/grants/nhmrc/334047 http://purl.org/au-research/grants/nhmrc/1127060 http://purl.org/au-research/grants/nhmrc/1173690 http://purl.org/au-research/grants/nhmrc/1136372 http://creativecommons.org/licenses/by/4.0/ fulltext |
| spellingShingle | Aged Female Humans Male Aspirin Australia Body Size Cause of Death Thinness Waist Circumference Humans Thinness Aspirin Body Size Cause of Death Aged Australia Female Male Waist Circumference Carr, P.R. Webb, K.L. Neumann, J.T. Thao, L.T.P. Beilin, L.J. Ernst, M.E. Fitzgibbon, B. Gasevic, D. Nelson, M.R. Newman, A.B. Orchard, S.G. Owen, A. Reid, Christopher Stocks, N.P. Tonkin, A.M. Woods, R.L. McNeil, J.J. Associations of body size with all-cause and cause-specific mortality in healthy older adults |
| title | Associations of body size with all-cause and cause-specific mortality in healthy older adults |
| title_full | Associations of body size with all-cause and cause-specific mortality in healthy older adults |
| title_fullStr | Associations of body size with all-cause and cause-specific mortality in healthy older adults |
| title_full_unstemmed | Associations of body size with all-cause and cause-specific mortality in healthy older adults |
| title_short | Associations of body size with all-cause and cause-specific mortality in healthy older adults |
| title_sort | associations of body size with all-cause and cause-specific mortality in healthy older adults |
| topic | Aged Female Humans Male Aspirin Australia Body Size Cause of Death Thinness Waist Circumference Humans Thinness Aspirin Body Size Cause of Death Aged Australia Female Male Waist Circumference |
| url | http://purl.org/au-research/grants/nhmrc/334047 http://purl.org/au-research/grants/nhmrc/334047 http://purl.org/au-research/grants/nhmrc/334047 http://purl.org/au-research/grants/nhmrc/334047 http://hdl.handle.net/20.500.11937/93105 |