Update on trials examining effects of night-time blood pressure lowering drug treatment on prevention of cardiovascular disease
Current evidence on benefits of night-time blood pressure (BP) lowering drug treatment on cardiovascular disease (CVD) prevention attributable to the Ambulatory Blood Pressure Monitoring in the Prediction of Cardiovascular Events and Effects of Chronotherapy (MAPEC) trial and Bedtime hypertension tr...
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| Format: | Journal Article |
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2022
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| Online Access: | http://purl.org/au-research/grants/nhmrc/1111170 http://hdl.handle.net/20.500.11937/93104 |
| _version_ | 1848765698897084416 |
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| author | Ho, Chau Le Bao Reid, Christopher |
| author_facet | Ho, Chau Le Bao Reid, Christopher |
| author_sort | Ho, Chau Le Bao |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Current evidence on benefits of night-time blood pressure (BP) lowering drug treatment on cardiovascular disease (CVD) prevention attributable to the Ambulatory Blood Pressure Monitoring in the Prediction of Cardiovascular Events and Effects of Chronotherapy (MAPEC) trial and Bedtime hypertension treatment improves cardiovascular risk reduction (Hygia) trials has raised concern on their validity and methodology. In this commentary, the authors have updated the progress of the ongoing trials that were planned to examine the effect of night-time BP lowering drug treatment on CVD prevention. As compared to MAPEC and Hygia trials, three pragmatic trials the Blood Pressure Medication Timing (BPMedtime) trial (US), the Treatment In Morning versus Evening (TIME) trial (UK), Bedmed and Bedmed-frail (Canada) were planned without ambulatory BP monitoring. The BPMedtime trial was stopped after the pilot phase due to underestimated sample size and insufficient funds. TIME trial (UK) had a similar issue when changing the sample size from 10,269 to more than 20,000 participants. The TIME trial was completed and the initial results showing that protection against heart attack, stroke and vascular death is not affected by whether antihypertensive medications are taken in the morning or evening. The full study of the TIME trial is published in December 2022. Bedmed and Bedmed-frail trials are ongoing and will be completed in 2023. Time of taking BP lowering drug should be determined by patients at their convenience to improve the adherence. There was no difference in adverse effects of taking BP lowering drugs at night or morning. Evidence on the effect of night-time treatment on CVD events is inconsistent. The results from ongoing trials in Canada will contribute evidence to the use of BP lowering drug treatment for the prevention of CVD. |
| first_indexed | 2025-11-14T11:39:24Z |
| format | Journal Article |
| id | curtin-20.500.11937-93104 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:39:24Z |
| publishDate | 2022 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-931042023-09-19T01:04:23Z Update on trials examining effects of night-time blood pressure lowering drug treatment on prevention of cardiovascular disease Ho, Chau Le Bao Reid, Christopher Current evidence on benefits of night-time blood pressure (BP) lowering drug treatment on cardiovascular disease (CVD) prevention attributable to the Ambulatory Blood Pressure Monitoring in the Prediction of Cardiovascular Events and Effects of Chronotherapy (MAPEC) trial and Bedtime hypertension treatment improves cardiovascular risk reduction (Hygia) trials has raised concern on their validity and methodology. In this commentary, the authors have updated the progress of the ongoing trials that were planned to examine the effect of night-time BP lowering drug treatment on CVD prevention. As compared to MAPEC and Hygia trials, three pragmatic trials the Blood Pressure Medication Timing (BPMedtime) trial (US), the Treatment In Morning versus Evening (TIME) trial (UK), Bedmed and Bedmed-frail (Canada) were planned without ambulatory BP monitoring. The BPMedtime trial was stopped after the pilot phase due to underestimated sample size and insufficient funds. TIME trial (UK) had a similar issue when changing the sample size from 10,269 to more than 20,000 participants. The TIME trial was completed and the initial results showing that protection against heart attack, stroke and vascular death is not affected by whether antihypertensive medications are taken in the morning or evening. The full study of the TIME trial is published in December 2022. Bedmed and Bedmed-frail trials are ongoing and will be completed in 2023. Time of taking BP lowering drug should be determined by patients at their convenience to improve the adherence. There was no difference in adverse effects of taking BP lowering drugs at night or morning. Evidence on the effect of night-time treatment on CVD events is inconsistent. The results from ongoing trials in Canada will contribute evidence to the use of BP lowering drug treatment for the prevention of CVD. 2022 Journal Article http://hdl.handle.net/20.500.11937/93104 10.37349/emed.2022.00107 http://purl.org/au-research/grants/nhmrc/1111170 http://creativecommons.org/licenses/by/4.0/ fulltext |
| spellingShingle | Ho, Chau Le Bao Reid, Christopher Update on trials examining effects of night-time blood pressure lowering drug treatment on prevention of cardiovascular disease |
| title | Update on trials examining effects of night-time blood pressure lowering drug treatment on prevention of cardiovascular disease |
| title_full | Update on trials examining effects of night-time blood pressure lowering drug treatment on prevention of cardiovascular disease |
| title_fullStr | Update on trials examining effects of night-time blood pressure lowering drug treatment on prevention of cardiovascular disease |
| title_full_unstemmed | Update on trials examining effects of night-time blood pressure lowering drug treatment on prevention of cardiovascular disease |
| title_short | Update on trials examining effects of night-time blood pressure lowering drug treatment on prevention of cardiovascular disease |
| title_sort | update on trials examining effects of night-time blood pressure lowering drug treatment on prevention of cardiovascular disease |
| url | http://purl.org/au-research/grants/nhmrc/1111170 http://hdl.handle.net/20.500.11937/93104 |