Prevalence and risk factors of peripheral artery disease in a population with chronic kidney disease in Australia: A systematic review and meta-analysis
There is a lack of clarity and guidance for screening peripheral artery disease (PAD) in persons with chronic kidney disease (CKD) and end stage kidney disease (ESKD) despite this group being at excess risk of cardiovascular disease (CVD). In this current study, we performed a systematic review and...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | English |
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WILEY
2021
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| Online Access: | http://purl.org/au-research/grants/nhmrc/1136372 http://hdl.handle.net/20.500.11937/93100 |
| _version_ | 1848765697567490048 |
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| author | Ho, C.L.B. Chih, H.J. Garimella, P.S. Matsushita, K. Jansen, Shirley Reid, Christopher |
| author_facet | Ho, C.L.B. Chih, H.J. Garimella, P.S. Matsushita, K. Jansen, Shirley Reid, Christopher |
| author_sort | Ho, C.L.B. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | There is a lack of clarity and guidance for screening peripheral artery disease (PAD) in persons with chronic kidney disease (CKD) and end stage kidney disease (ESKD) despite this group being at excess risk of cardiovascular disease (CVD). In this current study, we performed a systematic review and meta-analysis to examine the prevalence and risk factors for PAD in persons with CKD in Australian cohorts. We used the inverse variance heterogeneity meta-analysis with double arcsine transformation to summarize the prevalence of PAD (with 95% CIs). Nine studies and 18 reports from the Australia and New Zealand dialysis and transplant registry with 36 cohorts were included in the review. We found a substantially higher PAD prevalence in cohorts based on an ankle-brachial index (ABI) or toe systolic pressure (TBI) than cohorts based on self-reported history. Higher PAD prevalence was observed in ESKD persons than CKD persons without dialysis (PAD diagnosis based on ABI or TBI: 31% in ESKD persons and 23% in CKD persons, PAD diagnosis based on self-reported history: 17% in ESKD persons and 10% in CKD persons). Older age, Caucasian race, cerebrovascular disease and haemodialysis were associated with the presence of PAD in ESKD persons. Our findings indicated a considerable proportion of PAD in CKD and ESKD persons particularly in those with ESKD. To develop and provide an adequate plan to clinically manage CKD patients with PAD, evidence of cost-effectiveness and clinical benefit of early detection of PAD in persons with CKD in Australia is recommended for future studies. |
| first_indexed | 2025-11-14T11:39:22Z |
| format | Journal Article |
| id | curtin-20.500.11937-93100 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:39:22Z |
| publishDate | 2021 |
| publisher | WILEY |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-931002023-09-06T02:56:42Z Prevalence and risk factors of peripheral artery disease in a population with chronic kidney disease in Australia: A systematic review and meta-analysis Ho, C.L.B. Chih, H.J. Garimella, P.S. Matsushita, K. Jansen, Shirley Reid, Christopher Science & Technology Life Sciences & Biomedicine Urology & Nephrology chronic kidney disease end stage kidney disease peripheral artery disease NUTRITION EXAMINATION SURVEY BLOOD-PRESSURE INDEX NEW-ZEALAND DIALYSIS ALL-CAUSE MORTALITY RENAL-INSUFFICIENCY TRANSPLANT REGISTRY PERITONEAL-DIALYSIS VASCULAR-DISEASE NATIONAL-HEALTH BRACHIAL INDEX chronic kidney disease end stage kidney disease peripheral artery disease Aged Aged, 80 and over Australia Female Humans Male Middle Aged Peripheral Arterial Disease Prevalence Prognosis Renal Insufficiency, Chronic Risk Assessment Risk Factors Humans Prognosis Prevalence Risk Assessment Risk Factors Aged Aged, 80 and over Middle Aged Australia Female Male Renal Insufficiency, Chronic Peripheral Arterial Disease There is a lack of clarity and guidance for screening peripheral artery disease (PAD) in persons with chronic kidney disease (CKD) and end stage kidney disease (ESKD) despite this group being at excess risk of cardiovascular disease (CVD). In this current study, we performed a systematic review and meta-analysis to examine the prevalence and risk factors for PAD in persons with CKD in Australian cohorts. We used the inverse variance heterogeneity meta-analysis with double arcsine transformation to summarize the prevalence of PAD (with 95% CIs). Nine studies and 18 reports from the Australia and New Zealand dialysis and transplant registry with 36 cohorts were included in the review. We found a substantially higher PAD prevalence in cohorts based on an ankle-brachial index (ABI) or toe systolic pressure (TBI) than cohorts based on self-reported history. Higher PAD prevalence was observed in ESKD persons than CKD persons without dialysis (PAD diagnosis based on ABI or TBI: 31% in ESKD persons and 23% in CKD persons, PAD diagnosis based on self-reported history: 17% in ESKD persons and 10% in CKD persons). Older age, Caucasian race, cerebrovascular disease and haemodialysis were associated with the presence of PAD in ESKD persons. Our findings indicated a considerable proportion of PAD in CKD and ESKD persons particularly in those with ESKD. To develop and provide an adequate plan to clinically manage CKD patients with PAD, evidence of cost-effectiveness and clinical benefit of early detection of PAD in persons with CKD in Australia is recommended for future studies. 2021 Journal Article http://hdl.handle.net/20.500.11937/93100 10.1111/nep.13914 English http://purl.org/au-research/grants/nhmrc/1136372 WILEY unknown |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Urology & Nephrology chronic kidney disease end stage kidney disease peripheral artery disease NUTRITION EXAMINATION SURVEY BLOOD-PRESSURE INDEX NEW-ZEALAND DIALYSIS ALL-CAUSE MORTALITY RENAL-INSUFFICIENCY TRANSPLANT REGISTRY PERITONEAL-DIALYSIS VASCULAR-DISEASE NATIONAL-HEALTH BRACHIAL INDEX chronic kidney disease end stage kidney disease peripheral artery disease Aged Aged, 80 and over Australia Female Humans Male Middle Aged Peripheral Arterial Disease Prevalence Prognosis Renal Insufficiency, Chronic Risk Assessment Risk Factors Humans Prognosis Prevalence Risk Assessment Risk Factors Aged Aged, 80 and over Middle Aged Australia Female Male Renal Insufficiency, Chronic Peripheral Arterial Disease Ho, C.L.B. Chih, H.J. Garimella, P.S. Matsushita, K. Jansen, Shirley Reid, Christopher Prevalence and risk factors of peripheral artery disease in a population with chronic kidney disease in Australia: A systematic review and meta-analysis |
| title | Prevalence and risk factors of peripheral artery disease in a population with chronic kidney disease in Australia: A systematic review and meta-analysis |
| title_full | Prevalence and risk factors of peripheral artery disease in a population with chronic kidney disease in Australia: A systematic review and meta-analysis |
| title_fullStr | Prevalence and risk factors of peripheral artery disease in a population with chronic kidney disease in Australia: A systematic review and meta-analysis |
| title_full_unstemmed | Prevalence and risk factors of peripheral artery disease in a population with chronic kidney disease in Australia: A systematic review and meta-analysis |
| title_short | Prevalence and risk factors of peripheral artery disease in a population with chronic kidney disease in Australia: A systematic review and meta-analysis |
| title_sort | prevalence and risk factors of peripheral artery disease in a population with chronic kidney disease in australia: a systematic review and meta-analysis |
| topic | Science & Technology Life Sciences & Biomedicine Urology & Nephrology chronic kidney disease end stage kidney disease peripheral artery disease NUTRITION EXAMINATION SURVEY BLOOD-PRESSURE INDEX NEW-ZEALAND DIALYSIS ALL-CAUSE MORTALITY RENAL-INSUFFICIENCY TRANSPLANT REGISTRY PERITONEAL-DIALYSIS VASCULAR-DISEASE NATIONAL-HEALTH BRACHIAL INDEX chronic kidney disease end stage kidney disease peripheral artery disease Aged Aged, 80 and over Australia Female Humans Male Middle Aged Peripheral Arterial Disease Prevalence Prognosis Renal Insufficiency, Chronic Risk Assessment Risk Factors Humans Prognosis Prevalence Risk Assessment Risk Factors Aged Aged, 80 and over Middle Aged Australia Female Male Renal Insufficiency, Chronic Peripheral Arterial Disease |
| url | http://purl.org/au-research/grants/nhmrc/1136372 http://hdl.handle.net/20.500.11937/93100 |