Social isolation, social support and loneliness as predictors of cardiovascular disease incidence and mortality
Background: Poor social health is associated with increased risk of cardiovascular disease (CVD). Recent research suggests that different social health domains should be considered separately as the implications for health and possible interventions may differ. Aim: To assess social isolation, low s...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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BMC
2021
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| Online Access: | http://purl.org/au-research/grants/nhmrc/1136372 http://hdl.handle.net/20.500.11937/93099 |
| _version_ | 1848765697285423104 |
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| author | Freak-Poli, R. Ryan, J. Neumann, J.T. Tonkin, A. Reid, Christopher Woods, R.L. Nelson, M. Stocks, N. Berk, M. McNeil, J.J. Britt, C. Owen, A.J. |
| author_facet | Freak-Poli, R. Ryan, J. Neumann, J.T. Tonkin, A. Reid, Christopher Woods, R.L. Nelson, M. Stocks, N. Berk, M. McNeil, J.J. Britt, C. Owen, A.J. |
| author_sort | Freak-Poli, R. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Poor social health is associated with increased risk of cardiovascular disease (CVD). Recent research suggests that different social health domains should be considered separately as the implications for health and possible interventions may differ. Aim: To assess social isolation, low social support and loneliness as predictors of CVD. Methods: Secondary analysis of 11,486 community-dwelling, Australians, aged 70 years and over, free of CVD, dementia, or significant physical disability, from the ASPirin in Reducing Events in the Elderly (ASPREE) trial. Social isolation, social support (Revised Lubben Social Network Scale), and loneliness were assessed as predictors of CVD using Cox proportional-hazard regression. CVD events included fatal CVD, heart failure hospitalization, myocardial infarction and stroke. Analyses were adjusted for established CVD risk factors. Results: Individuals with poor social health were 42 % more likely to develop CVD (p = 0.01) and twice as likely to die from CVD (p = 0.02) over a median 4.5 years follow-up. Interaction effects indicated that poorer social health more strongly predicted CVD in smokers (HR 4.83, p = 0.001, p-interaction = 0.01), major city dwellers (HR 1.94, p < 0.001, p-interaction=0.03), and younger older adults (70-75 years; HR 2.12, p < 0.001, p-interaction = 0.01). Social isolation (HR 1.66, p = 0.04) and low social support (HR 2.05, p = 0.002), but not loneliness (HR 1.4, p = 0.1), predicted incident CVD. All measures of poor social health predicted ischemic stroke (HR 1.73 to 3.16). Conclusions: Among healthy older adults, social isolation and low social support may be more important than loneliness as cardiovascular risk factors. Social health domains should be considered in future CVD risk prediction models. |
| first_indexed | 2025-11-14T11:39:22Z |
| format | Journal Article |
| id | curtin-20.500.11937-93099 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:39:22Z |
| publishDate | 2021 |
| publisher | BMC |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-930992023-09-06T07:23:25Z Social isolation, social support and loneliness as predictors of cardiovascular disease incidence and mortality Freak-Poli, R. Ryan, J. Neumann, J.T. Tonkin, A. Reid, Christopher Woods, R.L. Nelson, M. Stocks, N. Berk, M. McNeil, J.J. Britt, C. Owen, A.J. Science & Technology Life Sciences & Biomedicine Geriatrics & Gerontology Gerontology Social Support Social Isolation Loneliness Cardiovascular Diseases Geriatrics Aging Interpersonal Relations RISK-FACTORS MYOCARDIAL-INFARCTION OLDER-ADULTS HEALTH STROKE CARE COMMUNITY IMPACT AGE Aging Cardiovascular Diseases Geriatrics Interpersonal Relations Loneliness Social Isolation Social Support Aged Aged, 80 and over Australia Cardiovascular Diseases Humans Incidence Loneliness Risk Factors Social Isolation Social Support Humans Cardiovascular Diseases Incidence Risk Factors Social Isolation Loneliness Social Support Aged Aged, 80 and over Australia Background: Poor social health is associated with increased risk of cardiovascular disease (CVD). Recent research suggests that different social health domains should be considered separately as the implications for health and possible interventions may differ. Aim: To assess social isolation, low social support and loneliness as predictors of CVD. Methods: Secondary analysis of 11,486 community-dwelling, Australians, aged 70 years and over, free of CVD, dementia, or significant physical disability, from the ASPirin in Reducing Events in the Elderly (ASPREE) trial. Social isolation, social support (Revised Lubben Social Network Scale), and loneliness were assessed as predictors of CVD using Cox proportional-hazard regression. CVD events included fatal CVD, heart failure hospitalization, myocardial infarction and stroke. Analyses were adjusted for established CVD risk factors. Results: Individuals with poor social health were 42 % more likely to develop CVD (p = 0.01) and twice as likely to die from CVD (p = 0.02) over a median 4.5 years follow-up. Interaction effects indicated that poorer social health more strongly predicted CVD in smokers (HR 4.83, p = 0.001, p-interaction = 0.01), major city dwellers (HR 1.94, p < 0.001, p-interaction=0.03), and younger older adults (70-75 years; HR 2.12, p < 0.001, p-interaction = 0.01). Social isolation (HR 1.66, p = 0.04) and low social support (HR 2.05, p = 0.002), but not loneliness (HR 1.4, p = 0.1), predicted incident CVD. All measures of poor social health predicted ischemic stroke (HR 1.73 to 3.16). Conclusions: Among healthy older adults, social isolation and low social support may be more important than loneliness as cardiovascular risk factors. Social health domains should be considered in future CVD risk prediction models. 2021 Journal Article http://hdl.handle.net/20.500.11937/93099 10.1186/s12877-021-02602-2 English http://purl.org/au-research/grants/nhmrc/1136372 http://creativecommons.org/licenses/by/4.0/ BMC fulltext |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Geriatrics & Gerontology Gerontology Social Support Social Isolation Loneliness Cardiovascular Diseases Geriatrics Aging Interpersonal Relations RISK-FACTORS MYOCARDIAL-INFARCTION OLDER-ADULTS HEALTH STROKE CARE COMMUNITY IMPACT AGE Aging Cardiovascular Diseases Geriatrics Interpersonal Relations Loneliness Social Isolation Social Support Aged Aged, 80 and over Australia Cardiovascular Diseases Humans Incidence Loneliness Risk Factors Social Isolation Social Support Humans Cardiovascular Diseases Incidence Risk Factors Social Isolation Loneliness Social Support Aged Aged, 80 and over Australia Freak-Poli, R. Ryan, J. Neumann, J.T. Tonkin, A. Reid, Christopher Woods, R.L. Nelson, M. Stocks, N. Berk, M. McNeil, J.J. Britt, C. Owen, A.J. Social isolation, social support and loneliness as predictors of cardiovascular disease incidence and mortality |
| title | Social isolation, social support and loneliness as predictors of cardiovascular disease incidence and mortality |
| title_full | Social isolation, social support and loneliness as predictors of cardiovascular disease incidence and mortality |
| title_fullStr | Social isolation, social support and loneliness as predictors of cardiovascular disease incidence and mortality |
| title_full_unstemmed | Social isolation, social support and loneliness as predictors of cardiovascular disease incidence and mortality |
| title_short | Social isolation, social support and loneliness as predictors of cardiovascular disease incidence and mortality |
| title_sort | social isolation, social support and loneliness as predictors of cardiovascular disease incidence and mortality |
| topic | Science & Technology Life Sciences & Biomedicine Geriatrics & Gerontology Gerontology Social Support Social Isolation Loneliness Cardiovascular Diseases Geriatrics Aging Interpersonal Relations RISK-FACTORS MYOCARDIAL-INFARCTION OLDER-ADULTS HEALTH STROKE CARE COMMUNITY IMPACT AGE Aging Cardiovascular Diseases Geriatrics Interpersonal Relations Loneliness Social Isolation Social Support Aged Aged, 80 and over Australia Cardiovascular Diseases Humans Incidence Loneliness Risk Factors Social Isolation Social Support Humans Cardiovascular Diseases Incidence Risk Factors Social Isolation Loneliness Social Support Aged Aged, 80 and over Australia |
| url | http://purl.org/au-research/grants/nhmrc/1136372 http://hdl.handle.net/20.500.11937/93099 |