The effect of depressive symptoms on disability-free survival in healthy older adults: A prospective cohort study
Background: Gerontology and ageing research are increasingly focussing on healthy life span (healthspan), the period of life lived free of serious disease and disability. Late-life depression (LLD) is believed to impact adversely on physical health. However, no studies have examined its effect on he...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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WILEY
2023
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| Online Access: | http://purl.org/au-research/grants/nhmrc/334047 http://hdl.handle.net/20.500.11937/93097 |
| _version_ | 1848765696760086528 |
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| author | Roebuck, G. Lotfaliany, M. Agustini, B. Forbes, M. Mohebbi, M. McNeil, J. Woods, R.L. Reid, Christopher Nelson, M.R. Shah, R.C. Ryan, J. Newman, A.B. Owen, A. Freak-Poli, R. Stocks, N. Berk, M. |
| author_facet | Roebuck, G. Lotfaliany, M. Agustini, B. Forbes, M. Mohebbi, M. McNeil, J. Woods, R.L. Reid, Christopher Nelson, M.R. Shah, R.C. Ryan, J. Newman, A.B. Owen, A. Freak-Poli, R. Stocks, N. Berk, M. |
| author_sort | Roebuck, G. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Gerontology and ageing research are increasingly focussing on healthy life span (healthspan), the period of life lived free of serious disease and disability. Late-life depression (LLD) is believed to impact adversely on physical health. However, no studies have examined its effect on healthspan. This study investigated the effect of LLD and subthreshold depression on disability-free survival, a widely accepted measure of healthspan. Methods: This prospective cohort study used data from the ASPirin in Reducing Events in the Elderly study. Participants were aged ≥70 years (or ≥65 years for African-American and Hispanic participants) and free of dementia, physical disability and cardiovascular disease. Depressive symptoms were measured using the 10-item Centre for Epidemiological Studies Depression Scale (CES-D-10). LLD and subthreshold depression were defined as CES-D-10 scores ≥8 and 3–7, respectively. Disability-free survival was defined as survival free of dementia and persistent physical disability. Results: A total of 19,110 participants were followed up for a maximum of 7.3 years. In female participants, LLD was associated with lower disability-free survival adjusting for sociodemographic and lifestyle factors, medical comorbidities, polypharmacy, physical function and antidepressant use (HR, 1.50; 95% CI, 1.23–1.82). In male participants, LLD was associated with lower disability-free survival adjusting for sociodemographic and lifestyle factors (HR, 1.30; 95% CI, 1.03–1.64). Subthreshold depression was also associated with lower disability-free survival in both sexes. Conclusions: LLD may be a common and important risk factor for shortened healthspan. |
| first_indexed | 2025-11-14T11:39:21Z |
| format | Journal Article |
| id | curtin-20.500.11937-93097 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:39:21Z |
| publishDate | 2023 |
| publisher | WILEY |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-930972023-09-18T07:39:34Z The effect of depressive symptoms on disability-free survival in healthy older adults: A prospective cohort study Roebuck, G. Lotfaliany, M. Agustini, B. Forbes, M. Mohebbi, M. McNeil, J. Woods, R.L. Reid, Christopher Nelson, M.R. Shah, R.C. Ryan, J. Newman, A.B. Owen, A. Freak-Poli, R. Stocks, N. Berk, M. Science & Technology Life Sciences & Biomedicine Psychiatry ageing disability-free survival healthspan late-life depression psychiatry LATE-LIFE DEPRESSION EXPECTANCY DISEASE BURDEN RISK ageing disability-free survival healthspan late-life depression psychiatry Aged Humans Male Female Depression Prospective Studies Antidepressive Agents Disabled Persons Dementia ASPREE Investigator Group Humans Dementia Antidepressive Agents Prospective Studies Depression Aged Disabled Persons Female Male Background: Gerontology and ageing research are increasingly focussing on healthy life span (healthspan), the period of life lived free of serious disease and disability. Late-life depression (LLD) is believed to impact adversely on physical health. However, no studies have examined its effect on healthspan. This study investigated the effect of LLD and subthreshold depression on disability-free survival, a widely accepted measure of healthspan. Methods: This prospective cohort study used data from the ASPirin in Reducing Events in the Elderly study. Participants were aged ≥70 years (or ≥65 years for African-American and Hispanic participants) and free of dementia, physical disability and cardiovascular disease. Depressive symptoms were measured using the 10-item Centre for Epidemiological Studies Depression Scale (CES-D-10). LLD and subthreshold depression were defined as CES-D-10 scores ≥8 and 3–7, respectively. Disability-free survival was defined as survival free of dementia and persistent physical disability. Results: A total of 19,110 participants were followed up for a maximum of 7.3 years. In female participants, LLD was associated with lower disability-free survival adjusting for sociodemographic and lifestyle factors, medical comorbidities, polypharmacy, physical function and antidepressant use (HR, 1.50; 95% CI, 1.23–1.82). In male participants, LLD was associated with lower disability-free survival adjusting for sociodemographic and lifestyle factors (HR, 1.30; 95% CI, 1.03–1.64). Subthreshold depression was also associated with lower disability-free survival in both sexes. Conclusions: LLD may be a common and important risk factor for shortened healthspan. 2023 Journal Article http://hdl.handle.net/20.500.11937/93097 10.1111/acps.13513 English http://purl.org/au-research/grants/nhmrc/334047 http://purl.org/au-research/grants/nhmrc/1081901 http://purl.org/au-research/grants/nhmrc/1127060 http://purl.org/au-research/grants/nhmrc/1173690 http://purl.org/au-research/grants/nhmrc/1136372 http://purl.org/au-research/grants/nhmrc/1135727 http://purl.org/au-research/grants/nhmrc/1156072 http://creativecommons.org/licenses/by/4.0/ WILEY fulltext |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Psychiatry ageing disability-free survival healthspan late-life depression psychiatry LATE-LIFE DEPRESSION EXPECTANCY DISEASE BURDEN RISK ageing disability-free survival healthspan late-life depression psychiatry Aged Humans Male Female Depression Prospective Studies Antidepressive Agents Disabled Persons Dementia ASPREE Investigator Group Humans Dementia Antidepressive Agents Prospective Studies Depression Aged Disabled Persons Female Male Roebuck, G. Lotfaliany, M. Agustini, B. Forbes, M. Mohebbi, M. McNeil, J. Woods, R.L. Reid, Christopher Nelson, M.R. Shah, R.C. Ryan, J. Newman, A.B. Owen, A. Freak-Poli, R. Stocks, N. Berk, M. The effect of depressive symptoms on disability-free survival in healthy older adults: A prospective cohort study |
| title | The effect of depressive symptoms on disability-free survival in healthy older adults: A prospective cohort study |
| title_full | The effect of depressive symptoms on disability-free survival in healthy older adults: A prospective cohort study |
| title_fullStr | The effect of depressive symptoms on disability-free survival in healthy older adults: A prospective cohort study |
| title_full_unstemmed | The effect of depressive symptoms on disability-free survival in healthy older adults: A prospective cohort study |
| title_short | The effect of depressive symptoms on disability-free survival in healthy older adults: A prospective cohort study |
| title_sort | effect of depressive symptoms on disability-free survival in healthy older adults: a prospective cohort study |
| topic | Science & Technology Life Sciences & Biomedicine Psychiatry ageing disability-free survival healthspan late-life depression psychiatry LATE-LIFE DEPRESSION EXPECTANCY DISEASE BURDEN RISK ageing disability-free survival healthspan late-life depression psychiatry Aged Humans Male Female Depression Prospective Studies Antidepressive Agents Disabled Persons Dementia ASPREE Investigator Group Humans Dementia Antidepressive Agents Prospective Studies Depression Aged Disabled Persons Female Male |
| url | http://purl.org/au-research/grants/nhmrc/334047 http://purl.org/au-research/grants/nhmrc/334047 http://purl.org/au-research/grants/nhmrc/334047 http://purl.org/au-research/grants/nhmrc/334047 http://purl.org/au-research/grants/nhmrc/334047 http://purl.org/au-research/grants/nhmrc/334047 http://purl.org/au-research/grants/nhmrc/334047 http://hdl.handle.net/20.500.11937/93097 |