Harmonising Individual Patient Level Cardiac Registry Data Across the Asia Pacific Region—A Feasibility Study of In-Hospital Outcomes of STEMI Patients From the Asia Pacific Evaluation of Cardiovascular Therapies (ASPECT) Network
Objective: The Asia-Pacific Evaluation of Cardiovascular Therapies (ASPECT) collaboration was established to inform on percutaneous coronary intervention (PCI) in the Asia-Pacific Region. Our aims were to (i) determine the operational requirements to assemble an international individual patient data...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Online Access: | http://purl.org/au-research/grants/nhmrc/546272 http://hdl.handle.net/20.500.11937/93096 |
| _version_ | 1848765696461242368 |
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| author | Reid, Christopher Chih, Jun Duffy, S.J. Brennan, A.L. Ajani, A.E. Beltrame, J. Tavella, R. Yan, B.P. Dinh, D. Chin, C.T. Do, L.D. Nguyen, Q.N. Nguyen, H.T.T. Wijaya, I.P. Yamin, M. Rusdi, L. Alwi, I. Sim, K.H. Yip Fong, A.Y. Wan Ahmad, W.A. Yeo, K.K. |
| author_facet | Reid, Christopher Chih, Jun Duffy, S.J. Brennan, A.L. Ajani, A.E. Beltrame, J. Tavella, R. Yan, B.P. Dinh, D. Chin, C.T. Do, L.D. Nguyen, Q.N. Nguyen, H.T.T. Wijaya, I.P. Yamin, M. Rusdi, L. Alwi, I. Sim, K.H. Yip Fong, A.Y. Wan Ahmad, W.A. Yeo, K.K. |
| author_sort | Reid, Christopher |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objective: The Asia-Pacific Evaluation of Cardiovascular Therapies (ASPECT) collaboration was established to inform on percutaneous coronary intervention (PCI) in the Asia-Pacific Region. Our aims were to (i) determine the operational requirements to assemble an international individual patient dataset and validate the processes of governance, data quality and data security, and subsequently (ii) describe the characteristics and outcomes for ST-elevation myocardial infarction (STEMI) patients undergoing PCI in the ASPECT registry. Methods: Seven (7) ASPECT members were approached to provide a harmonised anonymised dataset from their local registry. Patient characteristics were summarised and associations between the characteristics and in-hospital outcomes for STEMI patients were analysed. Results: Six (6) participating sites (86%) provided governance approvals for the collation of individual anonymised patient data from 2015 to 2017. Five (5) sites (83%) provided >90% of agreed data elements and 68% of the collated elements had <10% missingness. From the registry (n=12,620), 84% were male. The mean age was 59.2±12.3 years. The Malaysian cohort had a high prevalence of previous myocardial infarction (34%), almost twice that of any other sites (p<0.001). Adverse in-hospital outcomes were the lowest in Hong Kong whilst in-hospital mortality varied from 2.7% in Vietnam to 7.9% in Singapore. Conclusions: Governance approvals for the collation of individual patient anonymised data was achieved with a high level of data alignment. Secure data transfer process and repository were established. Patient characteristics and presentation varied significantly across the Asia-Pacific region with this likely to be a major predictor of variations in the clinical outcomes observed across the region. |
| first_indexed | 2025-11-14T11:39:21Z |
| format | Journal Article |
| id | curtin-20.500.11937-93096 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | eng |
| last_indexed | 2025-11-14T11:39:21Z |
| publishDate | 2023 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-930962023-09-18T04:59:51Z Harmonising Individual Patient Level Cardiac Registry Data Across the Asia Pacific Region—A Feasibility Study of In-Hospital Outcomes of STEMI Patients From the Asia Pacific Evaluation of Cardiovascular Therapies (ASPECT) Network Reid, Christopher Chih, Jun Duffy, S.J. Brennan, A.L. Ajani, A.E. Beltrame, J. Tavella, R. Yan, B.P. Dinh, D. Chin, C.T. Do, L.D. Nguyen, Q.N. Nguyen, H.T.T. Wijaya, I.P. Yamin, M. Rusdi, L. Alwi, I. Sim, K.H. Yip Fong, A.Y. Wan Ahmad, W.A. Yeo, K.K. Asia-Pacific Cardiovascular outcome Registry STEMI Humans Male Middle Aged Aged Female ST Elevation Myocardial Infarction Percutaneous Coronary Intervention Feasibility Studies Routinely Collected Health Data Risk Factors Hong Kong Registries Treatment Outcome ASPECT Investigators Humans Treatment Outcome Registries Risk Factors Feasibility Studies Aged Middle Aged Hong Kong Female Male Percutaneous Coronary Intervention ST Elevation Myocardial Infarction Routinely Collected Health Data Objective: The Asia-Pacific Evaluation of Cardiovascular Therapies (ASPECT) collaboration was established to inform on percutaneous coronary intervention (PCI) in the Asia-Pacific Region. Our aims were to (i) determine the operational requirements to assemble an international individual patient dataset and validate the processes of governance, data quality and data security, and subsequently (ii) describe the characteristics and outcomes for ST-elevation myocardial infarction (STEMI) patients undergoing PCI in the ASPECT registry. Methods: Seven (7) ASPECT members were approached to provide a harmonised anonymised dataset from their local registry. Patient characteristics were summarised and associations between the characteristics and in-hospital outcomes for STEMI patients were analysed. Results: Six (6) participating sites (86%) provided governance approvals for the collation of individual anonymised patient data from 2015 to 2017. Five (5) sites (83%) provided >90% of agreed data elements and 68% of the collated elements had <10% missingness. From the registry (n=12,620), 84% were male. The mean age was 59.2±12.3 years. The Malaysian cohort had a high prevalence of previous myocardial infarction (34%), almost twice that of any other sites (p<0.001). Adverse in-hospital outcomes were the lowest in Hong Kong whilst in-hospital mortality varied from 2.7% in Vietnam to 7.9% in Singapore. Conclusions: Governance approvals for the collation of individual patient anonymised data was achieved with a high level of data alignment. Secure data transfer process and repository were established. Patient characteristics and presentation varied significantly across the Asia-Pacific region with this likely to be a major predictor of variations in the clinical outcomes observed across the region. 2023 Journal Article http://hdl.handle.net/20.500.11937/93096 10.1016/j.hlc.2022.08.012 eng http://purl.org/au-research/grants/nhmrc/546272 http://purl.org/au-research/grants/nhmrc/1136372 http://creativecommons.org/licenses/by-nc-nd/4.0/ fulltext |
| spellingShingle | Asia-Pacific Cardiovascular outcome Registry STEMI Humans Male Middle Aged Aged Female ST Elevation Myocardial Infarction Percutaneous Coronary Intervention Feasibility Studies Routinely Collected Health Data Risk Factors Hong Kong Registries Treatment Outcome ASPECT Investigators Humans Treatment Outcome Registries Risk Factors Feasibility Studies Aged Middle Aged Hong Kong Female Male Percutaneous Coronary Intervention ST Elevation Myocardial Infarction Routinely Collected Health Data Reid, Christopher Chih, Jun Duffy, S.J. Brennan, A.L. Ajani, A.E. Beltrame, J. Tavella, R. Yan, B.P. Dinh, D. Chin, C.T. Do, L.D. Nguyen, Q.N. Nguyen, H.T.T. Wijaya, I.P. Yamin, M. Rusdi, L. Alwi, I. Sim, K.H. Yip Fong, A.Y. Wan Ahmad, W.A. Yeo, K.K. Harmonising Individual Patient Level Cardiac Registry Data Across the Asia Pacific Region—A Feasibility Study of In-Hospital Outcomes of STEMI Patients From the Asia Pacific Evaluation of Cardiovascular Therapies (ASPECT) Network |
| title | Harmonising Individual Patient Level Cardiac Registry Data Across the Asia Pacific Region—A Feasibility Study of In-Hospital Outcomes of STEMI Patients From the Asia Pacific Evaluation of Cardiovascular Therapies (ASPECT) Network |
| title_full | Harmonising Individual Patient Level Cardiac Registry Data Across the Asia Pacific Region—A Feasibility Study of In-Hospital Outcomes of STEMI Patients From the Asia Pacific Evaluation of Cardiovascular Therapies (ASPECT) Network |
| title_fullStr | Harmonising Individual Patient Level Cardiac Registry Data Across the Asia Pacific Region—A Feasibility Study of In-Hospital Outcomes of STEMI Patients From the Asia Pacific Evaluation of Cardiovascular Therapies (ASPECT) Network |
| title_full_unstemmed | Harmonising Individual Patient Level Cardiac Registry Data Across the Asia Pacific Region—A Feasibility Study of In-Hospital Outcomes of STEMI Patients From the Asia Pacific Evaluation of Cardiovascular Therapies (ASPECT) Network |
| title_short | Harmonising Individual Patient Level Cardiac Registry Data Across the Asia Pacific Region—A Feasibility Study of In-Hospital Outcomes of STEMI Patients From the Asia Pacific Evaluation of Cardiovascular Therapies (ASPECT) Network |
| title_sort | harmonising individual patient level cardiac registry data across the asia pacific region—a feasibility study of in-hospital outcomes of stemi patients from the asia pacific evaluation of cardiovascular therapies (aspect) network |
| topic | Asia-Pacific Cardiovascular outcome Registry STEMI Humans Male Middle Aged Aged Female ST Elevation Myocardial Infarction Percutaneous Coronary Intervention Feasibility Studies Routinely Collected Health Data Risk Factors Hong Kong Registries Treatment Outcome ASPECT Investigators Humans Treatment Outcome Registries Risk Factors Feasibility Studies Aged Middle Aged Hong Kong Female Male Percutaneous Coronary Intervention ST Elevation Myocardial Infarction Routinely Collected Health Data |
| url | http://purl.org/au-research/grants/nhmrc/546272 http://purl.org/au-research/grants/nhmrc/546272 http://hdl.handle.net/20.500.11937/93096 |