Autoantibodies and cancer among asbestos-exposed cohorts in Western Australia
Asbestos exposure is associated with many adverse health conditions including malignant mesothelioma and lung cancer as well as production of autoantibodies. Autoantibodies may serve as biomarkers for asbestos exposure in patients with cancer, and autoimmune dysfunction has been linked to increased...
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| Format: | Journal Article |
| Language: | English |
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TAYLOR & FRANCIS INC
2021
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| Online Access: | http://hdl.handle.net/20.500.11937/93003 |
| _version_ | 1848765686425321472 |
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| author | Carey, Renee Pfau, J.C. Fritzler, M.J. Creaney, J. de Klerk, N. Musk, A. W. (Bill) Franklin, P. Sodhi-Berry, N. Brims, Fraser Reid, Alison |
| author_facet | Carey, Renee Pfau, J.C. Fritzler, M.J. Creaney, J. de Klerk, N. Musk, A. W. (Bill) Franklin, P. Sodhi-Berry, N. Brims, Fraser Reid, Alison |
| author_sort | Carey, Renee |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Asbestos exposure is associated with many adverse health conditions including malignant mesothelioma and lung cancer as well as production of autoantibodies. Autoantibodies may serve as biomarkers for asbestos exposure in patients with cancer, and autoimmune dysfunction has been linked to increased rates of various cancers. The aim of this study was to examine the hypothesis that autoantibodies are more frequent in asbestos-exposed individuals with either lung cancer or mesothelioma than those without these conditions. Asbestos-exposed individuals from Western Australia who had lung cancer (n = 24), malignant mesothelioma (n = 24), or no malignancy (n = 51) were tested for antinuclear autoantibodies (ANA) using indirect immunofluorescence and specific extractable nuclear autoantibodies (ENA) employing a multiplexed addressable laser bead immunoassay. Contrary to the hypothesis, data demonstrated that individuals without malignancy were more likely to be positive for ANA compared to those with cancer. However, autoantibodies to histone and Ro-60 were found to be associated with lung cancer. These results support a possible predictive value for specific autoantibodies in the early detection of lung cancer and/or in our understanding of the role of autoimmune processes in cancer. However, further studies are needed to identify specific target antigens for the antibodies. |
| first_indexed | 2025-11-14T11:39:12Z |
| format | Journal Article |
| id | curtin-20.500.11937-93003 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:39:12Z |
| publishDate | 2021 |
| publisher | TAYLOR & FRANCIS INC |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-930032023-08-28T01:46:53Z Autoantibodies and cancer among asbestos-exposed cohorts in Western Australia Carey, Renee Pfau, J.C. Fritzler, M.J. Creaney, J. de Klerk, N. Musk, A. W. (Bill) Franklin, P. Sodhi-Berry, N. Brims, Fraser Reid, Alison Science & Technology Life Sciences & Biomedicine Environmental Sciences Public, Environmental & Occupational Health Toxicology Environmental Sciences & Ecology Asbestos autoimmune antibodies cancer exposure lung cancer malignant mesothelioma Asbestos autoimmune antibodies cancer exposure lung cancer malignant mesothelioma Aged Asbestos Autoantibodies Female Humans Lung Neoplasms Male Mesothelioma, Malignant Middle Aged Mining Occupational Exposure Western Australia Humans Lung Neoplasms Asbestos Autoantibodies Occupational Exposure Mining Aged Middle Aged Western Australia Female Male Mesothelioma, Malignant Asbestos exposure is associated with many adverse health conditions including malignant mesothelioma and lung cancer as well as production of autoantibodies. Autoantibodies may serve as biomarkers for asbestos exposure in patients with cancer, and autoimmune dysfunction has been linked to increased rates of various cancers. The aim of this study was to examine the hypothesis that autoantibodies are more frequent in asbestos-exposed individuals with either lung cancer or mesothelioma than those without these conditions. Asbestos-exposed individuals from Western Australia who had lung cancer (n = 24), malignant mesothelioma (n = 24), or no malignancy (n = 51) were tested for antinuclear autoantibodies (ANA) using indirect immunofluorescence and specific extractable nuclear autoantibodies (ENA) employing a multiplexed addressable laser bead immunoassay. Contrary to the hypothesis, data demonstrated that individuals without malignancy were more likely to be positive for ANA compared to those with cancer. However, autoantibodies to histone and Ro-60 were found to be associated with lung cancer. These results support a possible predictive value for specific autoantibodies in the early detection of lung cancer and/or in our understanding of the role of autoimmune processes in cancer. However, further studies are needed to identify specific target antigens for the antibodies. 2021 Journal Article http://hdl.handle.net/20.500.11937/93003 10.1080/15287394.2021.1889424 English TAYLOR & FRANCIS INC fulltext |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Environmental Sciences Public, Environmental & Occupational Health Toxicology Environmental Sciences & Ecology Asbestos autoimmune antibodies cancer exposure lung cancer malignant mesothelioma Asbestos autoimmune antibodies cancer exposure lung cancer malignant mesothelioma Aged Asbestos Autoantibodies Female Humans Lung Neoplasms Male Mesothelioma, Malignant Middle Aged Mining Occupational Exposure Western Australia Humans Lung Neoplasms Asbestos Autoantibodies Occupational Exposure Mining Aged Middle Aged Western Australia Female Male Mesothelioma, Malignant Carey, Renee Pfau, J.C. Fritzler, M.J. Creaney, J. de Klerk, N. Musk, A. W. (Bill) Franklin, P. Sodhi-Berry, N. Brims, Fraser Reid, Alison Autoantibodies and cancer among asbestos-exposed cohorts in Western Australia |
| title | Autoantibodies and cancer among asbestos-exposed cohorts in Western Australia |
| title_full | Autoantibodies and cancer among asbestos-exposed cohorts in Western Australia |
| title_fullStr | Autoantibodies and cancer among asbestos-exposed cohorts in Western Australia |
| title_full_unstemmed | Autoantibodies and cancer among asbestos-exposed cohorts in Western Australia |
| title_short | Autoantibodies and cancer among asbestos-exposed cohorts in Western Australia |
| title_sort | autoantibodies and cancer among asbestos-exposed cohorts in western australia |
| topic | Science & Technology Life Sciences & Biomedicine Environmental Sciences Public, Environmental & Occupational Health Toxicology Environmental Sciences & Ecology Asbestos autoimmune antibodies cancer exposure lung cancer malignant mesothelioma Asbestos autoimmune antibodies cancer exposure lung cancer malignant mesothelioma Aged Asbestos Autoantibodies Female Humans Lung Neoplasms Male Mesothelioma, Malignant Middle Aged Mining Occupational Exposure Western Australia Humans Lung Neoplasms Asbestos Autoantibodies Occupational Exposure Mining Aged Middle Aged Western Australia Female Male Mesothelioma, Malignant |
| url | http://hdl.handle.net/20.500.11937/93003 |