Characterising Interactions Between Amyloid-beta 42 and Amylin Peptide Heterodimers: A Molecular Simulation Approach
Amyloid-beta 42 (Aß42) and amylin are intrinsically disordered peptides. Pathogenic aggregation of peptides results in Alzheimer’s disease (AD) and Type-2 diabetes (T2D), by Aß42 and amylin, respectively. High risk of AD in T2D patients exists due to cross-aggregation in brain. Difficulty in in-vitr...
| Main Author: | Sonar, Krushna Satish |
|---|---|
| Format: | Thesis |
| Published: |
Curtin University
2022
|
| Online Access: | http://hdl.handle.net/20.500.11937/92792 |
Similar Items
Molecular simulation between amyloid beta (1-42), a
Peptide associated with alzheimer disease, and zinc(ii) ion
by: Abdul Ghani, Nur Syafiqah
Published: (2016)
by: Abdul Ghani, Nur Syafiqah
Published: (2016)
Molecular docking studies on the interaction of anti-alzheimer compounds with amyloid beta peptides
by: Faujan, Nur Hana, et al.
Published: (2019)
by: Faujan, Nur Hana, et al.
Published: (2019)
Novel phage peptides attenuate beta amyloid-42 catalysed hydrogen peroxide production and associated neurotoxicity
by: Taddei, K., et al.
Published: (2010)
by: Taddei, K., et al.
Published: (2010)
Molecular dynamics simulation of collagen binding to an amyloid-beta monomer and its effect on the peptide structure
by: Zakaria, Norzalina, et al.
Published: (2021)
by: Zakaria, Norzalina, et al.
Published: (2021)
A yeast model for studying intracellular clearance of beta-amyloid 42
by: Bharadwaj, Prashant, et al.
Published: (2012)
by: Bharadwaj, Prashant, et al.
Published: (2012)
The structure and dynamics of plasma high-density lipoproteins and their interactions with the beta-amyloid peptide
by: Malajczuk, Chris
Published: (2022)
by: Malajczuk, Chris
Published: (2022)
Computational Elucidation Of Binding Interactions For Thicapa And Poet On Amyloid Beta 42 And Presenilin 1 In
Treating Alzheimer’s Disease
by: Mohd Suhaimi, Ahmad Marwazi
Published: (2024)
by: Mohd Suhaimi, Ahmad Marwazi
Published: (2024)
Characterisation of the structure and oligomerisation of islet amyloid polypeptides (IAPP): A review of molecular dynamics simulation studies
by: Moore, S., et al.
Published: (2018)
by: Moore, S., et al.
Published: (2018)
Oligomeric and fibrillar amyloid beta 42 induce platelet aggregation partially through GPVI
by: Elaskalani, O., et al.
Published: (2017)
by: Elaskalani, O., et al.
Published: (2017)
The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-ß, Amylin, and Tau Proteins
by: Bharadwaj, Prashant, et al.
Published: (2017)
by: Bharadwaj, Prashant, et al.
Published: (2017)
Modulation of amyloid-ß 1-42 structure and toxicity by proline-rich whey peptides
by: Bharadwaj, Prashant, et al.
Published: (2013)
by: Bharadwaj, Prashant, et al.
Published: (2013)
Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor
by: Xie, Ling, et al.
Published: (2002)
by: Xie, Ling, et al.
Published: (2002)
Validation and characterisation of a novel peptide that binds monomeric and aggregated beta-amyloid and inhibits the formation of neurotoxic oligomers
by: Barr, R., et al.
Published: (2015)
by: Barr, R., et al.
Published: (2015)
Modulation of Amyloid Beta (Aß) Structure and Toxicity by a Dairy-derived Peptide Product
by: Bennett, L., et al.
Published: (2010)
by: Bennett, L., et al.
Published: (2010)
The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer’s Beta Amyloid
by: Verdile, Giuseppe, et al.
Published: (2007)
by: Verdile, Giuseppe, et al.
Published: (2007)
Unveiling amyloid-β1–42 interaction with zinc in water and mixed hexafluoroisopropanol solution in Alzheimer’s disease
by: Ghani, Nur Syafiqah Abdul, et al.
Published: (2017)
by: Ghani, Nur Syafiqah Abdul, et al.
Published: (2017)
The role of copper(II) in the aggregation of human amylin
by: Sinopoli, Alessandro, et al.
Published: (2014)
by: Sinopoli, Alessandro, et al.
Published: (2014)
Induction of DNA damage and cell death by Beta Amyloid Peptide and its modification by Tocotrienol Rich Fraction (TRF)
by: Musalmah,, et al.
Published: (2009)
by: Musalmah,, et al.
Published: (2009)
Finding chemopreventatives to reduce amyloid beta in yeast
by: Macreadie, I., et al.
Published: (2016)
by: Macreadie, I., et al.
Published: (2016)
Asymptomatic neurotoxicity of amyloid Î-peptides AÎ1-42 and AÎ25-35 on mouse embryonic stem cell-derived neural cells
by: Mansor, Nur Izzati, et al.
Published: (2021)
by: Mansor, Nur Izzati, et al.
Published: (2021)
Autoantibody-catalyzed hydrolysis of amyloid ß peptide
by: Taguchi, H., et al.
Published: (2008)
by: Taguchi, H., et al.
Published: (2008)
The role of gonadotropins and testosterone in the regulation of beta amyloid metabolism
by: Verdile, Giuseppe, et al.
Published: (2009)
by: Verdile, Giuseppe, et al.
Published: (2009)
Discovery and characterisation of anti-amyloid beta fibril antibodies from naive phage display VHH libraries
by: Fernandez Bonfante, Juan
Published: (2022)
by: Fernandez Bonfante, Juan
Published: (2022)
Molecular simulations of venom peptide-membrane interactions: Progress and challenges
by: Deplazes, Evelyne
Published: (2018)
by: Deplazes, Evelyne
Published: (2018)
Asymptomatic neurotoxicity of amyloid β-peptides (Aβ1-42 and Aβ25-35) on mouse embryonic stem cell-derived neural cells
by: Mansor, Nur Izzati, et al.
Published: (2020)
by: Mansor, Nur Izzati, et al.
Published: (2020)
The differential effects of fatty acids on enterocytic abundance of amyloid-beta
by: Galloway, Susan, et al.
Published: (2019)
by: Galloway, Susan, et al.
Published: (2019)
Interactive Effects of Dietary Fat and APOE Genotype on Peripheral Amyloid-Beta: Implications for Alzheimer’s Disease Risk
by: D'Alonzo, Zachary John
Published: (2025)
by: D'Alonzo, Zachary John
Published: (2025)
Enterocyte Beta Amyloid-Lipoprotein Homeostasis: Implications for Alzheimer's Disease Risk
by: Galloway, Susan
Published: (2015)
by: Galloway, Susan
Published: (2015)
Amyloid-beta colocalizes with apolipoprotein B in absorptive cells of the small intestine
by: Galloway, Susan, et al.
Published: (2009)
by: Galloway, Susan, et al.
Published: (2009)
Spontaneous Formation of Heterodimer Au–Fe7S8 Nanoplatelets by a Seeded Growth Approach
by: Javaid, S., et al.
Published: (2019)
by: Javaid, S., et al.
Published: (2019)
Plasma Amyloid-beta as a Biomarker in Alzheimer's Disease: The AIBL Study of Aging
by: Lui, J., et al.
Published: (2010)
by: Lui, J., et al.
Published: (2010)
Associations between gonadotropins, testosterone and [beta] amyloid in men at risk of Alzheimer’s disease
by: Verdile, Giuseppe, et al.
Published: (2014)
by: Verdile, Giuseppe, et al.
Published: (2014)
The effect of exogenous cholesterol and lipid-modulating agents on enterocytic amyloid-beta abundance
by: Galloway, Susan, et al.
Published: (2009)
by: Galloway, Susan, et al.
Published: (2009)
Cognition and beta-amyloid in preclinical Alzheimer's disease: Data from the AIBL study
by: Pike, K., et al.
Published: (2011)
by: Pike, K., et al.
Published: (2011)
Assessment of a Novel Enhanced Sampling Method for Molecular Simulations of Peptide-membrane Interactions
by: Tanner, John Douglas
Published: (2020)
by: Tanner, John Douglas
Published: (2020)
Molecular characterisation of beta thalassaemia in patients from Sabah, Malaysia
by: Teh, Lai Kuan
Published: (2014)
by: Teh, Lai Kuan
Published: (2014)
Role of the cell membrane interface in modulating production and uptake of Alzheimer's beta amyloid protein
by: Bharadwaj, Prashant, et al.
Published: (2018)
by: Bharadwaj, Prashant, et al.
Published: (2018)
Effect of fatty acids on enterocytic beta-amyloid abundance: Possible aetiology in Alzheimer’s disease
by: Galloway, S., et al.
Published: (2008)
by: Galloway, S., et al.
Published: (2008)
Clearance mechanisms of Alzheimer’s amyloid-b peptide: implications for therapeutic design and diagnostic tests
by: Bates, K., et al.
Published: (2009)
by: Bates, K., et al.
Published: (2009)
Peripheral metabolism of lipoprotein-amyloid beta as a risk factor for Alzheimer's disease: potential interactive effects of APOE genotype with dietary fats
by: D'Alonzo, Zachary, et al.
Published: (2023)
by: D'Alonzo, Zachary, et al.
Published: (2023)
Similar Items
-
Molecular simulation between amyloid beta (1-42), a
Peptide associated with alzheimer disease, and zinc(ii) ion
by: Abdul Ghani, Nur Syafiqah
Published: (2016) -
Molecular docking studies on the interaction of anti-alzheimer compounds with amyloid beta peptides
by: Faujan, Nur Hana, et al.
Published: (2019) -
Novel phage peptides attenuate beta amyloid-42 catalysed hydrogen peroxide production and associated neurotoxicity
by: Taddei, K., et al.
Published: (2010) -
Molecular dynamics simulation of collagen binding to an amyloid-beta monomer and its effect on the peptide structure
by: Zakaria, Norzalina, et al.
Published: (2021) -
A yeast model for studying intracellular clearance of beta-amyloid 42
by: Bharadwaj, Prashant, et al.
Published: (2012)