Omega-3 Index, fish consumption, use of fish oil supplements and first clinical diagnosis of central nervous system demyelination
Higher intakes of omega-3 polyunsaturated fatty acids (n3PUFAs) have been associated with lower MS risk. We aimed to test associations between the Omega-3 Index, blood levels of n3PUFAs, fish oil supplement use, and fish consumption with a first clinical diagnosis of CNS demyelination (FCD). Cases (...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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ELSEVIER SCI LTD
2021
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| Online Access: | http://hdl.handle.net/20.500.11937/92742 |
| _version_ | 1848765661842505728 |
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| author | Daly, Alison Martin, Christopher Sherriff, Jill Mori, T.A. Pereira, Gavin Lucas, R.M. Ponsonby, A.L. Taylor, B. van der Mei, I. Black, Lucinda Ausimmune Investigator Group |
| author_facet | Daly, Alison Martin, Christopher Sherriff, Jill Mori, T.A. Pereira, Gavin Lucas, R.M. Ponsonby, A.L. Taylor, B. van der Mei, I. Black, Lucinda Ausimmune Investigator Group |
| author_sort | Daly, Alison |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Higher intakes of omega-3 polyunsaturated fatty acids (n3PUFAs) have been associated with lower MS risk. We aimed to test associations between the Omega-3 Index, blood levels of n3PUFAs, fish oil supplement use, and fish consumption with a first clinical diagnosis of CNS demyelination (FCD). Cases (n = 250) had a higher Omega-3 Index compared with a matched group of controls (n = 471) (average treatment effect (ATE)=0.31, p = 0.047, based on augmented inverse probability weighting). A higher percentage of cases than controls used fish oil supplements (cases=17% vs. controls=10%). We found that Omega-3 Index increased as time between FCD and study interview increased (e.g., at or below median (112 days), based on ATE, mean=5.30, 95% CI 5.08, 5.53; above median, mean=5.90, 95% CI 5.51, 6.30). Fish oil supplement use increased in a similar manner (at or below median (112 days), based on ATE, proportion=0.12, 95% CI 0.06, 0.18; above the median, proportion=0.21, 95% CI 0.14, 0.28). Our results suggest a behaviour change post FCD with increased use of fish oil supplements. |
| first_indexed | 2025-11-14T11:38:48Z |
| format | Journal Article |
| id | curtin-20.500.11937-92742 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:38:48Z |
| publishDate | 2021 |
| publisher | ELSEVIER SCI LTD |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-927422023-07-25T02:02:45Z Omega-3 Index, fish consumption, use of fish oil supplements and first clinical diagnosis of central nervous system demyelination Daly, Alison Martin, Christopher Sherriff, Jill Mori, T.A. Pereira, Gavin Lucas, R.M. Ponsonby, A.L. Taylor, B. van der Mei, I. Black, Lucinda Ausimmune Investigator Group Science & Technology Life Sciences & Biomedicine Clinical Neurology Neurosciences & Neurology Polyunsaturated fatty acids Omega-3 index Fish oil supplements Multiple sclerosis Ausimmune study RISK Ausimmune study Fish oil supplements Multiple sclerosis Omega-3 index Polyunsaturated fatty acids Central Nervous System Demyelinating Diseases Dietary Supplements Fatty Acids, Omega-3 Fish Oils Humans Ausimmune Investigator Group Central Nervous System Humans Demyelinating Diseases Fatty Acids, Omega-3 Fish Oils Dietary Supplements Higher intakes of omega-3 polyunsaturated fatty acids (n3PUFAs) have been associated with lower MS risk. We aimed to test associations between the Omega-3 Index, blood levels of n3PUFAs, fish oil supplement use, and fish consumption with a first clinical diagnosis of CNS demyelination (FCD). Cases (n = 250) had a higher Omega-3 Index compared with a matched group of controls (n = 471) (average treatment effect (ATE)=0.31, p = 0.047, based on augmented inverse probability weighting). A higher percentage of cases than controls used fish oil supplements (cases=17% vs. controls=10%). We found that Omega-3 Index increased as time between FCD and study interview increased (e.g., at or below median (112 days), based on ATE, mean=5.30, 95% CI 5.08, 5.53; above median, mean=5.90, 95% CI 5.51, 6.30). Fish oil supplement use increased in a similar manner (at or below median (112 days), based on ATE, proportion=0.12, 95% CI 0.06, 0.18; above the median, proportion=0.21, 95% CI 0.14, 0.28). Our results suggest a behaviour change post FCD with increased use of fish oil supplements. 2021 Journal Article http://hdl.handle.net/20.500.11937/92742 10.1016/j.msard.2021.103210 English ELSEVIER SCI LTD fulltext |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Clinical Neurology Neurosciences & Neurology Polyunsaturated fatty acids Omega-3 index Fish oil supplements Multiple sclerosis Ausimmune study RISK Ausimmune study Fish oil supplements Multiple sclerosis Omega-3 index Polyunsaturated fatty acids Central Nervous System Demyelinating Diseases Dietary Supplements Fatty Acids, Omega-3 Fish Oils Humans Ausimmune Investigator Group Central Nervous System Humans Demyelinating Diseases Fatty Acids, Omega-3 Fish Oils Dietary Supplements Daly, Alison Martin, Christopher Sherriff, Jill Mori, T.A. Pereira, Gavin Lucas, R.M. Ponsonby, A.L. Taylor, B. van der Mei, I. Black, Lucinda Ausimmune Investigator Group Omega-3 Index, fish consumption, use of fish oil supplements and first clinical diagnosis of central nervous system demyelination |
| title | Omega-3 Index, fish consumption, use of fish oil supplements and first clinical diagnosis of central nervous system demyelination |
| title_full | Omega-3 Index, fish consumption, use of fish oil supplements and first clinical diagnosis of central nervous system demyelination |
| title_fullStr | Omega-3 Index, fish consumption, use of fish oil supplements and first clinical diagnosis of central nervous system demyelination |
| title_full_unstemmed | Omega-3 Index, fish consumption, use of fish oil supplements and first clinical diagnosis of central nervous system demyelination |
| title_short | Omega-3 Index, fish consumption, use of fish oil supplements and first clinical diagnosis of central nervous system demyelination |
| title_sort | omega-3 index, fish consumption, use of fish oil supplements and first clinical diagnosis of central nervous system demyelination |
| topic | Science & Technology Life Sciences & Biomedicine Clinical Neurology Neurosciences & Neurology Polyunsaturated fatty acids Omega-3 index Fish oil supplements Multiple sclerosis Ausimmune study RISK Ausimmune study Fish oil supplements Multiple sclerosis Omega-3 index Polyunsaturated fatty acids Central Nervous System Demyelinating Diseases Dietary Supplements Fatty Acids, Omega-3 Fish Oils Humans Ausimmune Investigator Group Central Nervous System Humans Demyelinating Diseases Fatty Acids, Omega-3 Fish Oils Dietary Supplements |
| url | http://hdl.handle.net/20.500.11937/92742 |