Pigment epithelium-derived factor and menopause in metastatic breast cancer
This thesis investigated PEDF and menopause in metastatic breast cancer. Using immunohistochemistry and immunocytochemistry staining techniques, and cell-based functional assays, this thesis found that PEDF expression, anti-metastatic function and potential functional mechanisms are regulated by pos...
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| Format: | Thesis |
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Curtin University
2022
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| Online Access: | http://hdl.handle.net/20.500.11937/92740 |
| _version_ | 1848765661240623104 |
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| author | Brook, Naomi Louise |
| author_facet | Brook, Naomi Louise |
| author_sort | Brook, Naomi Louise |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This thesis investigated PEDF and menopause in metastatic breast cancer. Using immunohistochemistry and immunocytochemistry staining techniques, and cell-based functional assays, this thesis found that PEDF expression, anti-metastatic function and potential functional mechanisms are regulated by post-menopausal oestrogen levels in oestrogen receptor positive breast cancer and by pre-menopausal oestrogen levels in triple negative breast cancer. This thesis identifies two potential breast cancer patient populations who may derive greater clinical benefit from future therapeutic PEDF development. |
| first_indexed | 2025-11-14T11:38:48Z |
| format | Thesis |
| id | curtin-20.500.11937-92740 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:38:48Z |
| publishDate | 2022 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-927402025-07-17T05:20:36Z Pigment epithelium-derived factor and menopause in metastatic breast cancer Brook, Naomi Louise This thesis investigated PEDF and menopause in metastatic breast cancer. Using immunohistochemistry and immunocytochemistry staining techniques, and cell-based functional assays, this thesis found that PEDF expression, anti-metastatic function and potential functional mechanisms are regulated by post-menopausal oestrogen levels in oestrogen receptor positive breast cancer and by pre-menopausal oestrogen levels in triple negative breast cancer. This thesis identifies two potential breast cancer patient populations who may derive greater clinical benefit from future therapeutic PEDF development. 2022 Thesis http://hdl.handle.net/20.500.11937/92740 Curtin University fulltext |
| spellingShingle | Brook, Naomi Louise Pigment epithelium-derived factor and menopause in metastatic breast cancer |
| title | Pigment epithelium-derived factor and
menopause in metastatic breast cancer |
| title_full | Pigment epithelium-derived factor and
menopause in metastatic breast cancer |
| title_fullStr | Pigment epithelium-derived factor and
menopause in metastatic breast cancer |
| title_full_unstemmed | Pigment epithelium-derived factor and
menopause in metastatic breast cancer |
| title_short | Pigment epithelium-derived factor and
menopause in metastatic breast cancer |
| title_sort | pigment epithelium-derived factor and
menopause in metastatic breast cancer |
| url | http://hdl.handle.net/20.500.11937/92740 |