Pigment epithelium-derived factor and menopause in metastatic breast cancer
This thesis investigated PEDF and menopause in metastatic breast cancer. Using immunohistochemistry and immunocytochemistry staining techniques, and cell-based functional assays, this thesis found that PEDF expression, anti-metastatic function and potential functional mechanisms are regulated by pos...
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| Format: | Thesis |
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Curtin University
2022
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| Online Access: | http://hdl.handle.net/20.500.11937/92740 |
| Summary: | This thesis investigated PEDF and menopause in metastatic breast cancer. Using immunohistochemistry and immunocytochemistry staining techniques, and cell-based functional assays, this thesis found that PEDF expression, anti-metastatic function and potential functional mechanisms are regulated by post-menopausal oestrogen levels in oestrogen receptor positive breast cancer and by pre-menopausal oestrogen levels in triple negative breast cancer. This thesis identifies two potential breast cancer patient populations who may derive greater clinical benefit from future therapeutic PEDF development. |
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