Nutrients, herbal bioactive derivatives and commensal microbiota as tools to lower the risk of SARS-CoV-2 infection
The SARS-CoV-2 outbreak has infected a vast population across the world, causing more than 664 million cases and 6.7 million deaths by January 2023. Vaccination has been effective in reducing the most critical aftermath of this infection, but some issues are still present regarding re-infection prev...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
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Frontiers Media
2023
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| Online Access: | FIR2021 to RV http://hdl.handle.net/20.500.11937/92503 |
| _version_ | 1848765643915001856 |
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| author | Romani, Arianna Sergi, Domenico Zauli, Enrico Voltan, Rebecca Lodi, Giada Vaccarezza, Mauro Caruso, Lorenzo Previati, Maurizio Zauli, Giorgio |
| author_facet | Romani, Arianna Sergi, Domenico Zauli, Enrico Voltan, Rebecca Lodi, Giada Vaccarezza, Mauro Caruso, Lorenzo Previati, Maurizio Zauli, Giorgio |
| author_sort | Romani, Arianna |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The SARS-CoV-2 outbreak has infected a vast population across the world, causing more than 664 million cases and 6.7 million deaths by January 2023. Vaccination has been effective in reducing the most critical aftermath of this infection, but some issues are still present regarding re-infection prevention, effectiveness against variants, vaccine hesitancy and worldwide accessibility. Moreover, although several old and new antiviral drugs have been tested, we still lack robust and specific treatment modalities. It appears of utmost importance, facing this continuously growing pandemic, to focus on alternative practices grounded on firm scientific bases. In this article, we aim to outline a rigorous scientific background and propose complementary nutritional tools useful toward containment, and ultimately control, of SARS-CoV-2 infection. In particular, we review the mechanisms of viral entry and discuss the role of polyunsaturated fatty acids derived from α-linolenic acid and other nutrients in preventing the interaction of SARS-CoV-2 with its entry gateways. In a similar way, we analyze in detail the role of herbal-derived pharmacological compounds and specific microbial strains or microbial-derived polypeptides in the prevention of SARS-CoV-2 entry. In addition, we highlight the role of probiotics, nutrients and herbal-derived compounds in stimulating the immunity response. |
| first_indexed | 2025-11-14T11:38:31Z |
| format | Journal Article |
| id | curtin-20.500.11937-92503 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:38:31Z |
| publishDate | 2023 |
| publisher | Frontiers Media |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-925032024-02-07T07:03:59Z Nutrients, herbal bioactive derivatives and commensal microbiota as tools to lower the risk of SARS-CoV-2 infection Romani, Arianna Sergi, Domenico Zauli, Enrico Voltan, Rebecca Lodi, Giada Vaccarezza, Mauro Caruso, Lorenzo Previati, Maurizio Zauli, Giorgio SARS-CoV2 COVID19 natural products phytochemicals ACE-2 TMPRSS2 The SARS-CoV-2 outbreak has infected a vast population across the world, causing more than 664 million cases and 6.7 million deaths by January 2023. Vaccination has been effective in reducing the most critical aftermath of this infection, but some issues are still present regarding re-infection prevention, effectiveness against variants, vaccine hesitancy and worldwide accessibility. Moreover, although several old and new antiviral drugs have been tested, we still lack robust and specific treatment modalities. It appears of utmost importance, facing this continuously growing pandemic, to focus on alternative practices grounded on firm scientific bases. In this article, we aim to outline a rigorous scientific background and propose complementary nutritional tools useful toward containment, and ultimately control, of SARS-CoV-2 infection. In particular, we review the mechanisms of viral entry and discuss the role of polyunsaturated fatty acids derived from α-linolenic acid and other nutrients in preventing the interaction of SARS-CoV-2 with its entry gateways. In a similar way, we analyze in detail the role of herbal-derived pharmacological compounds and specific microbial strains or microbial-derived polypeptides in the prevention of SARS-CoV-2 entry. In addition, we highlight the role of probiotics, nutrients and herbal-derived compounds in stimulating the immunity response. 2023 Journal Article http://hdl.handle.net/20.500.11937/92503 10.3389/fnut.2023.1152254 FIR2021 to RV http://creativecommons.org/licenses/by/4.0/ Frontiers Media fulltext |
| spellingShingle | SARS-CoV2 COVID19 natural products phytochemicals ACE-2 TMPRSS2 Romani, Arianna Sergi, Domenico Zauli, Enrico Voltan, Rebecca Lodi, Giada Vaccarezza, Mauro Caruso, Lorenzo Previati, Maurizio Zauli, Giorgio Nutrients, herbal bioactive derivatives and commensal microbiota as tools to lower the risk of SARS-CoV-2 infection |
| title | Nutrients, herbal bioactive derivatives and commensal microbiota as tools to lower the risk of SARS-CoV-2 infection |
| title_full | Nutrients, herbal bioactive derivatives and commensal microbiota as tools to lower the risk of SARS-CoV-2 infection |
| title_fullStr | Nutrients, herbal bioactive derivatives and commensal microbiota as tools to lower the risk of SARS-CoV-2 infection |
| title_full_unstemmed | Nutrients, herbal bioactive derivatives and commensal microbiota as tools to lower the risk of SARS-CoV-2 infection |
| title_short | Nutrients, herbal bioactive derivatives and commensal microbiota as tools to lower the risk of SARS-CoV-2 infection |
| title_sort | nutrients, herbal bioactive derivatives and commensal microbiota as tools to lower the risk of sars-cov-2 infection |
| topic | SARS-CoV2 COVID19 natural products phytochemicals ACE-2 TMPRSS2 |
| url | FIR2021 to RV http://hdl.handle.net/20.500.11937/92503 |