Isolation and Synthesis of Anti-Inflammatory Compounds from Dodonaea Species
In this thesis Dodonaea species were investigated for their bioactive natural products, focusing on their anti-inflammatory activity. Dodonaea adenophora (Kalgoorlie) yielded numerous clerodanes diterpenoids, of which one proved to be highly active as an anti-malarial and as an anti-cancer agent, wi...
| Main Author: | |
|---|---|
| Format: | Thesis |
| Published: |
Curtin University
2022
|
| Online Access: | http://hdl.handle.net/20.500.11937/92351 |
| _version_ | 1848765638283100160 |
|---|---|
| author | Atkinson, Robert David John |
| author_facet | Atkinson, Robert David John |
| author_sort | Atkinson, Robert David John |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | In this thesis Dodonaea species were investigated for their bioactive natural products, focusing on their anti-inflammatory activity. Dodonaea adenophora (Kalgoorlie) yielded numerous clerodanes diterpenoids, of which one proved to be highly active as an anti-malarial and as an anti-cancer agent, with low toxicity. The structure of these clerodanes was modified to better resemble polyandric acid A, a known anti-inflammatory. Dodonaea boroniifolia (cult.) yielded two novel cembrane diterpenoids, whose bioactivity and chemistry were explored. |
| first_indexed | 2025-11-14T11:38:26Z |
| format | Thesis |
| id | curtin-20.500.11937-92351 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:38:26Z |
| publishDate | 2022 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-923512025-06-16T03:26:31Z Isolation and Synthesis of Anti-Inflammatory Compounds from Dodonaea Species Atkinson, Robert David John In this thesis Dodonaea species were investigated for their bioactive natural products, focusing on their anti-inflammatory activity. Dodonaea adenophora (Kalgoorlie) yielded numerous clerodanes diterpenoids, of which one proved to be highly active as an anti-malarial and as an anti-cancer agent, with low toxicity. The structure of these clerodanes was modified to better resemble polyandric acid A, a known anti-inflammatory. Dodonaea boroniifolia (cult.) yielded two novel cembrane diterpenoids, whose bioactivity and chemistry were explored. 2022 Thesis http://hdl.handle.net/20.500.11937/92351 Curtin University fulltext |
| spellingShingle | Atkinson, Robert David John Isolation and Synthesis of Anti-Inflammatory Compounds from Dodonaea Species |
| title | Isolation and Synthesis of Anti-Inflammatory Compounds from
Dodonaea Species |
| title_full | Isolation and Synthesis of Anti-Inflammatory Compounds from
Dodonaea Species |
| title_fullStr | Isolation and Synthesis of Anti-Inflammatory Compounds from
Dodonaea Species |
| title_full_unstemmed | Isolation and Synthesis of Anti-Inflammatory Compounds from
Dodonaea Species |
| title_short | Isolation and Synthesis of Anti-Inflammatory Compounds from
Dodonaea Species |
| title_sort | isolation and synthesis of anti-inflammatory compounds from
dodonaea species |
| url | http://hdl.handle.net/20.500.11937/92351 |