Characterisation of bone marrow soluble factors and mesenchymal stem cells in B-cell acute lymphoblastic leukaemia
This thesis provides novel insight into the complexity of the bone marrow environment of B-cell acute lymphoblastic leukaemia or B-ALL, the most common cancer in children. Specifically, my project characterised bone marrow soluble factors during disease development. Furthermore, we identified cellul...
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| Format: | Thesis |
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Curtin University
2023
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| Online Access: | http://hdl.handle.net/20.500.11937/92348 |
| _version_ | 1848765637492473856 |
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| author | Hughes, Anastasia Mae |
| author_facet | Hughes, Anastasia Mae |
| author_sort | Hughes, Anastasia Mae |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This thesis provides novel insight into the complexity of the bone marrow environment of B-cell acute lymphoblastic leukaemia or B-ALL, the most common cancer in children. Specifically, my project characterised bone marrow soluble factors during disease development. Furthermore, we identified cellular and molecular changes in leukaemia-associated mesenchymal stem cells. In conclusion, this study provides further understanding of B-ALL biology and has brought us closer to exploiting new therapeutic targets to treat children with leukaemia. |
| first_indexed | 2025-11-14T11:38:25Z |
| format | Thesis |
| id | curtin-20.500.11937-92348 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:38:25Z |
| publishDate | 2023 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-923482025-06-16T03:26:31Z Characterisation of bone marrow soluble factors and mesenchymal stem cells in B-cell acute lymphoblastic leukaemia Hughes, Anastasia Mae This thesis provides novel insight into the complexity of the bone marrow environment of B-cell acute lymphoblastic leukaemia or B-ALL, the most common cancer in children. Specifically, my project characterised bone marrow soluble factors during disease development. Furthermore, we identified cellular and molecular changes in leukaemia-associated mesenchymal stem cells. In conclusion, this study provides further understanding of B-ALL biology and has brought us closer to exploiting new therapeutic targets to treat children with leukaemia. 2023 Thesis http://hdl.handle.net/20.500.11937/92348 Curtin University fulltext |
| spellingShingle | Hughes, Anastasia Mae Characterisation of bone marrow soluble factors and mesenchymal stem cells in B-cell acute lymphoblastic leukaemia |
| title | Characterisation of bone marrow soluble factors and
mesenchymal stem cells in B-cell acute lymphoblastic
leukaemia |
| title_full | Characterisation of bone marrow soluble factors and
mesenchymal stem cells in B-cell acute lymphoblastic
leukaemia |
| title_fullStr | Characterisation of bone marrow soluble factors and
mesenchymal stem cells in B-cell acute lymphoblastic
leukaemia |
| title_full_unstemmed | Characterisation of bone marrow soluble factors and
mesenchymal stem cells in B-cell acute lymphoblastic
leukaemia |
| title_short | Characterisation of bone marrow soluble factors and
mesenchymal stem cells in B-cell acute lymphoblastic
leukaemia |
| title_sort | characterisation of bone marrow soluble factors and
mesenchymal stem cells in b-cell acute lymphoblastic
leukaemia |
| url | http://hdl.handle.net/20.500.11937/92348 |