Characterisation of bone marrow soluble factors and mesenchymal stem cells in B-cell acute lymphoblastic leukaemia
This thesis provides novel insight into the complexity of the bone marrow environment of B-cell acute lymphoblastic leukaemia or B-ALL, the most common cancer in children. Specifically, my project characterised bone marrow soluble factors during disease development. Furthermore, we identified cellul...
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| Format: | Thesis |
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Curtin University
2023
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| Online Access: | http://hdl.handle.net/20.500.11937/92348 |
| Summary: | This thesis provides novel insight into the complexity of the bone marrow environment of B-cell acute lymphoblastic leukaemia or B-ALL, the most common cancer in children. Specifically, my project characterised bone marrow soluble factors during disease development. Furthermore, we identified cellular and molecular changes in leukaemia-associated mesenchymal stem cells. In conclusion, this study provides further understanding of B-ALL biology and has brought us closer to exploiting new therapeutic targets to treat children with leukaemia. |
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