Development and Evaluation of a Novel Buccal Dosage Form of Ketamine
Widespread therapeutic use of ketamine is limited by adverse effects and poor oral bioavailability, therefore improved formulations are required. In this project, mucoadhesive and orally disintegrating buccal films containing plain ketamine or ketamine-loaded microparticles were developed and charac...
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| Format: | Thesis |
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Curtin University
2022
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| Online Access: | http://hdl.handle.net/20.500.11937/92327 |
| _version_ | 1848765633744863232 |
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| author | Jahan, Fatima |
| author_facet | Jahan, Fatima |
| author_sort | Jahan, Fatima |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Widespread therapeutic use of ketamine is limited by adverse effects and poor oral bioavailability, therefore improved formulations are required. In this project, mucoadhesive and orally disintegrating buccal films containing plain ketamine or ketamine-loaded microparticles were developed and characterised. Pharmacokinetic properties of optimized films were compared against ketamine oral solution and sublingual lozenges in rabbits. Results showed that buccal films may be preferable in pain management, due to enhanced bioavailability and sustained ketamine absorption. |
| first_indexed | 2025-11-14T11:38:21Z |
| format | Thesis |
| id | curtin-20.500.11937-92327 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:38:21Z |
| publishDate | 2022 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-923272025-06-16T03:26:31Z Development and Evaluation of a Novel Buccal Dosage Form of Ketamine Jahan, Fatima Widespread therapeutic use of ketamine is limited by adverse effects and poor oral bioavailability, therefore improved formulations are required. In this project, mucoadhesive and orally disintegrating buccal films containing plain ketamine or ketamine-loaded microparticles were developed and characterised. Pharmacokinetic properties of optimized films were compared against ketamine oral solution and sublingual lozenges in rabbits. Results showed that buccal films may be preferable in pain management, due to enhanced bioavailability and sustained ketamine absorption. 2022 Thesis http://hdl.handle.net/20.500.11937/92327 Curtin University fulltext |
| spellingShingle | Jahan, Fatima Development and Evaluation of a Novel Buccal Dosage Form of Ketamine |
| title | Development and Evaluation of a Novel Buccal Dosage Form of
Ketamine |
| title_full | Development and Evaluation of a Novel Buccal Dosage Form of
Ketamine |
| title_fullStr | Development and Evaluation of a Novel Buccal Dosage Form of
Ketamine |
| title_full_unstemmed | Development and Evaluation of a Novel Buccal Dosage Form of
Ketamine |
| title_short | Development and Evaluation of a Novel Buccal Dosage Form of
Ketamine |
| title_sort | development and evaluation of a novel buccal dosage form of
ketamine |
| url | http://hdl.handle.net/20.500.11937/92327 |